Abstract:-Background:-A huge number of drugs are prescribed by Ayurvedic physicians to the patients of diabeteslike diseases and number of preparation are traditionally used by different school of practitioners, since thousands of years. Among them Katak Khadiradi Kashayamhas been advocated in Sahasra Yogam(A popular book on Kerliya tradition of Ayurvedic treatment). Andis being practiced in Southern part of India,since two hundred years to treat Diabetes Mellitus. Though principally its mode of action is well established as per Ayurvedic parameters, it is a need of time to establish this on the basis of modern biochemical and pharmacological parameters. Methods:-we searched Pubmed and scholarly articles with the help of google search engine to see that is there any kind of alkaloid present in any drug of this combination which shows antidiabetic or hypoglycemic effect.For this each drug of this combination is studied separately on the basis of previous researches especially animal experiments and data is gathered. Results:-Extract of almost each drug shows anti-hyperglycemic effect along with rejunuvative and antioxidant properties in experimental or animal studies. Conclusion:-Hence, Katak Khadiradi Kashayam has an effect on protecting β-cells and smoothing out fluctuation in glucose levels. shows antidiabetic effect along with antioxidant property which can be very helpful for diabetes Mellitus.