Retracted: Gastroprotective effects of Corchorus olitorius leaf extract against ethanol‐induced gastric mucosal hemorrhagic lesions in rats

Abstract

Background and AimCorchorus olitorius is a medicinal plant traditionally utilized as an antifertility, anti-convulsive, and purgative agent. This study aimed to evaluate the gastroprotective effect of an ethanolic extract of C. olitorius against ethanol-induced gastric ulcers in adult Sprague Dawley rats.MethodsThe rats were divided into seven groups according to their pretreatment: an untreated control group, an ulcer control group, a reference control group (20 mg/kg omeprazole), and four experimental groups (50, 100, 200, or 400 mg/kg of extract). Carboxymethyl cellulose was the vehicle for the agents. Prior to the induction of gastric ulcers with absolute ethanol, the rats in each group were pretreated orally. An hour later, the rats were sacrificed, and gastric tissues were collected to evaluate the ulcers and to measure enzymatic activity. The tissues were subjected to histological and immunohistochemical evaluations.ResultsCompared with the extensive mucosal damage in the ulcer control group, gross evaluation revealed a marked protection of the gastric mucosa in the experimental groups, with significantly preserved gastric wall mucus. In these groups, superoxide dismutase and malondialdehyde levels were significantly increased (P < 0.05) and reduced (P < 0.05), respectively. In addition to the histologic analyses (HE and periodic acid-Schiff staining), immunohistochemistry confirmed the protection through the upregulation of Hsp70 and the downregulation of Bax proteins. The gastroprotection of the experimental groups was comparable to that of the reference control medicine omeprazole.ConclusionsOur study reports the gastroprotective property of an ethanolic extract of C. olitorius against ethanol-induced gastric mucosal hemorrhagic lesions in rats.

Acute Toxicity and Gastroprotective Role ofM. pruriensin Ethanol-Induced Gastric Mucosal Injuries in Rats

“…Immunohistochemical staining of Bax protein of gastric mucosa in rats pretreated with M. pruriens extract or omeprazole showed downregulation of Bax protein. Similar to the previous studies [40–43], the expression of Bax protein in the ulcer control group was found upregulated compared to the groups pretreated either with omeprazole or with plant extract. …”

“…Hsp70 prevents these partially denatured proteins from aggregating and allows them to refold. As previous studies reported that the overexpression of Hsp70 could protect stomach [40–43], this study showed that the plant extract protected the gastric tissues through upregulation of Hsp70. Our results showed significant expression of Hsp70 in the extract control group and the experimental group.…”

“…The activation and infiltration of neutrophils appeared as a key factor in initial processes of gastric lesions formation. Several studies showed that reduction of neutrophil infiltration into ulcerated gastric tissues promoted the prevention of gastric ulcers in rats [40–43]. …”

Therapeutic Potential ofMyrtus communisSubsp.communisExtract Against Acetic ACID-Induced Colonic Inflammation in Rats

“…Recently, various plant extracts have been claimed to be useful for therapy of gastrointestinal disorders and have been widely investigated (Al Batran et al . ; Das et al . ; Sanchez et al .…”

Phytochemical Investigation of Corchorus olitorius L. Leaves Cultivated in Iraq and it’s In Vitro Antiviral Activity

“…(8) , (Escherichia coli, and Yersinia enterocolitica). Also against fungal micro-organisms (Geotrichum candidum and Botrytis cinerea) (5) , Anti-inflammatory (7) , Gastroprotective activity (33) , and Antiviral activity (12) . The aim of this study is to: 1-Demonstrating an overview of chemical constituent and pharmacological activity of leaves extracts from Corchorus olitorius.…”