<i>Pvu</i> II polymorphisms at the porcine oestrogen receptor locus <i>(ESR)</i>*

Rothschild, Max F.; Larson, R. G.; Jacobson, Carol D.; Pearson, Paul L.

doi:10.1111/j.1365-2052.1991.tb00715.x

Cited by 28 publications

(12 citation statements)

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“…This result fits earlier findings both in clinical medicine (18) and in veterinary medicine (20,21), where this polymorphic variant is used for the prediction of litter size, but stands in contrast to findings in an Asian population, in which the TT-allele was found to be associated with POF (22). The ESR1-PvuII polymorphism is located in an intron (base pair no.…”

Section: Discussionsupporting

confidence: 90%

The CC-allele of the PvuII polymorphic variant in intron 1 of the α-estrogen receptor gene is significantly more prevalent among infertile women at risk of premature ovarian aging

M’Rabet

Moffat

Helbling

et al. 2012

Fertility and Sterility

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Section: Discussionsupporting

confidence: 90%

The CC-allele of the PvuII polymorphic variant in intron 1 of the α-estrogen receptor gene is significantly more prevalent among infertile women at risk of premature ovarian aging

M’Rabet

Moffat

Helbling

et al. 2012

Fertility and Sterility

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“…For example, the oestrogen receptor gene (ESR) for litter size in pigs. In 1991, Rosthschild et al [27] first reported a polymorphism in ESR gene that was in significant association with litter size in pigs, which was subsequently confirmed by Short et al [28] and Isler et al [29] . However, Gibson et al [30] have found no detectable association of the marker with the trait in pig populations.…”

Section: Y 0 Could Effectively Mark Low Body Weight In Masmentioning

confidence: 85%

yellow0, a marker for low body weight in Drosophila melanogaster

Deng

2009

SCI CHINA SER C

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Marker-assisted selection (MAS) is an important modern breeding technique, but it has been found that the effect of the markers for quantitative trait loci (QTL) is inconsistent, leading in some cases to MAS failure and raising doubts about its effectiveness. Here the model organism Drosophila melanogaster was employed to study whether an effective marker could be found and applied to MAS. We crossed the stock carrying the y (0) marker (a recessive mutation allele of the yellow gene on the X chromosome) with three other stocks carrying corresponding wild-type markers in an F2 design, and found that the y (0) marker was in significant association with low body weight (P<0.001). This association was consistent across different backgrounds and the marker effects in female and male were approximately 0.95 sigma (P) (phenotypic standard deviation) and 0.68 sigma (P), respectively. We next introgressed a fragment via the y (0) marker into a wild stock background over 20 generations of marker-assisted introgression (MAI), and constructed the introgression stock y (0)(OR)20 in which body weight decreased by 13% and 7%, in female and male, respectively, compared to the wild stock (P<0.0001). This indicated that there must be a single QTL for low body weight that is tightly linked to the y (0) marker. We then shortened the introgressed fragment to less than 1.5 cM by a deeper MAI using the y (0) marker and the white marker. This narrower fragment also resulted in a similar decrease in body weight to that induced by y (0)(OR)20, indicating that the QTL for low body weight is located within this less-than-1.5 cM interval. Molecular characteristics of the y (0) marker by PCR amplification and Southern blotting revealed that yellow gene was deficient in the y (0) stock, leading to disappearance of melanin from the cuticle and probably influencing the developmental process. The above results confirmed the existence of effective QTL markers applicable to MAS breeding schemes, and their potential application in breeding new stocks.

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“…The ESR gene is considered as a candidate gene for reproduction. The relationship between the PvuII polymorphism of ESR gene (Rothschild et al, 1991) and reproduction traits was studied by many authors, e.g. by Depuydt et al (1999), Linville et al (2001), Isler et al (2002) and Van Rens et al (2002).…”

mentioning

confidence: 99%

“…The divergences or rather antagonistic results may be caused by the disparity of studied populations. Hybrids or very divergent breeds such as Meishan and Large White are often studied (Rothschild et al, 1991;Li et al, 1998). Our study tried to evaluate the effect of three candidate genes in one herd of Large White breed.…”

mentioning

confidence: 99%

Effect of estrogen receptor, follicle stimulating hormone and myogenin genes on the performance of Large White sows

Humpolíček¹,

Urban²,

Matoušek³

et al. 2007

CZECH J ANIM SCI

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AbstrAct:The study was designed to determine the associations between the Estrogen Receptor Gene (ESR -PvuII), Follicle Stimulating Hormone Gene (FSHB -HaeIII) and Myogenin Gene (MYOG -MspI) with traits characterizing the sow efficiency comprehensively. Concretely, the age of the first conception (AFC), service period (SP), insemination interval (InI), total number of piglets born (TNB), number of piglets born alive (NBA), number of piglets weaned (NW), lean meat content (LMC), backfat thickness (BFT) and average daily gain (ADG) were included in the study. Significant effects of ESR and FSHB genes on litter size (particularly in the second parity) and on reproduction traits were found in the investigated population. The influence of MYOG gene on reproduction traits was observed but there was no effect of this gene on litter size. None of the included genes had an effect on growth traits. The results outline the possible application of the above-mentioned genes in selection of Large White sows.

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Pvu II polymorphisms at the porcine oestrogen receptor locus *(ESR)**

Cited by 28 publications

References 1 publication

The CC-allele of the PvuII polymorphic variant in intron 1 of the α-estrogen receptor gene is significantly more prevalent among infertile women at risk of premature ovarian aging

The CC-allele of the PvuII polymorphic variant in intron 1 of the α-estrogen receptor gene is significantly more prevalent among infertile women at risk of premature ovarian aging

yellow0, a marker for low body weight in Drosophila melanogaster

Effect of estrogen receptor, follicle stimulating hormone and myogenin genes on the performance of Large White sows

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Pvu II polymorphisms at the porcine oestrogen receptor locus (ESR)*

Cited by 28 publications

References 1 publication

The CC-allele of the PvuII polymorphic variant in intron 1 of the α-estrogen receptor gene is significantly more prevalent among infertile women at risk of premature ovarian aging

The CC-allele of the PvuII polymorphic variant in intron 1 of the α-estrogen receptor gene is significantly more prevalent among infertile women at risk of premature ovarian aging

yellow0, a marker for low body weight in Drosophila melanogaster

Effect of estrogen receptor, follicle stimulating hormone and myogenin genes on the performance of Large White sows

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Pvu II polymorphisms at the porcine oestrogen receptor locus *(ESR)**