<i>p</i>‐Coumaric acid improves oxidative and osmosis stress responses in <i>Caenorhabditis elegans</i>

Yue, Yiren; Shen, Peiyi; Xu, Yuejia; Park, Yeonhwa

doi:10.1002/jsfa.9288

Cited by 35 publications

(33 citation statements)

References 40 publications

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“…21,22 Yue Y. et al showed that p-CA reduces oxidative stress. 23 It has been demonstrated that p-CA has antifungal, antiviral, anti-melanogenic, antioxidant, and anti-infl ammatory effects. 24,18 Therefore, in this study, the effects of p-CA on oxidant/antioxidant balance in the R-IR model were investigated via biochemical measurements.…”

Section: Introductionmentioning

confidence: 99%

Protective Effect of p-Coumaric Acid as Free Oxygen Radical Scavenger in Experimental Renal Ischemia-Reperfusion Model

Güzel

Tanyeli

2018

Sakarya Medical Journal

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Aim The aim of this study is to evaluate the antioxidant effect of p-Coumaric Acid (p-CA) on tissue damage due to ischemia-reperfusion in rat kidney tissue. ( Sakarya Med J 2018, 8(3):625-631)Methods Thirty-two 12-16 week-old Wistar Albino female rats weighing 200-250 g were used in this study. Rats underwent right nephrectomy intraperitoneally with an incision made in the dorsal region under ketamine (75 mg/kg) and xylazine (8 mg/kg) anesthesia. These rats were randomly divided into four groups in equal numbers (n = 8). Groups were classifi ed as the sham (S), renal ischemia-reperfusion (R-IR), 50 mg/kg p-CA with R-IR (p-CA 50), and 100 mg/kg p-CA with R-IR (p-CA 100). After the dorsum of all rats was opened and the right nephrectomy was performed, all groups except sham were clamped on the left renal artery and ischemia and reperfusion protocol was performed. P-CA was administered in two doses, 60 min before ischemia and 30 min before reperfusion. Total antioxidant levels (TAS), total oxidant level (TOS), superoxide dismutase (SOD), malondialdehyde (MDA), and myeloperoxidase (MPO) levels of left kidney were measured spectrophotometrically, and oxidative stress index (OSI) was calculated.Results TOS, MDA, MPO, and OSI values increased in R-IR group compared to S (p <0.01), while TAS and SOD values decreased. Increase in TAS and SOD values, a decrease in TOS, MDA, MPO, and OSI values were observed in P-CA applied groups (p <0.05).Conclusion Our fi ndings indicate that p-CA administration in renal ischemia-reperfusion injury may play a role in protecting tissue by reducing oxidant damage.

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Section: Introductionmentioning

confidence: 99%

Protective Effect of p-Coumaric Acid as Free Oxygen Radical Scavenger in Experimental Renal Ischemia-Reperfusion Model

Güzel

Tanyeli

2018

Sakarya Medical Journal

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“…7 Thus, it is possible that butein's triglyceride-lowering effects via SKN-1-dependent pathway is due to SKN-1 activation by post-translational changes, which can occur with or without changes on skn-1 at transcript levels. 42,[44][45][46][47] However, it is yet not known whether butein induce SKN-1/Nrf activation by post-translational changes; thus, further studies are needed to determine the effects of butein on SKN-1/Nrf regulators, such as PMK-1 (the homolog of MAPK), and subsequently their contribution for the lipogenesis in C. elegans. 37,48 The butein's inhibitory effects on SCD homologs contribute to the reduced triglycerides in C. elegans, similar to the inhibitory effects on SCD by other polyphenols, such as fisetin, hesperidin, quercetin and resveratrol derivative in rats or C. elegans.…”

Section: Discussionmentioning

confidence: 99%

Butein inhibits lipogenesis in Caenorhabditis elegans

et al. 2020

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Butein, a flavonoid found in annatto seeds and lacquer trees, may be used for many health benefits, including the prevention of obesity. However, its antiobesity effects are not completely understood; in particular, the effects of butein on the regulation of lipid metabolism have not been explained. Thus, the goal of the current study was to determine the effects of butein on lipid metabolism in Caenorhabditis elegans, which is a multi-organ nematode used as an animal model in obesity research. Butein at 70 μM reduced triglyceride content by 27% compared to the control without altering food intake and energy expenditure. The reduced triglyceride content by butein was associated with the downregulation of sbp-1, fasn-1, and fat-7, the lipogenesis-related homologs of sterol regulatory element-binding proteins, fatty acid synthase and stearoyl-CoA desaturase, respectively. Furthermore, fat-7 and skn-1, a homolog of nuclear respiratory factors, were identified as genetic requirements for butein's effects on triglyceride content in C. elegans. The effects of butein on sbp-1 and fasn-1 were dependent on skn-1, but the downregulation of fat-7 was independent of skn-1. These results suggest that the inhibitory effects of butein on lipogenesis are via SKN-1-and FAT-7-dependent pathways in C. elegans.

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“…Catechin and p-coumaric acid have also anti-oxidant, anticancer, anti-bacterial effects are available [72,73] and their values were significantly lower than other phenols and control group (Fig. 3).…”

Section: Various Effects Of Phenolic Substancesmentioning

confidence: 95%

Aspergillus alliaceus infection fatally shifts Orobanche hormones and phenolic metabolism

Aybeke

2020

Braz J Microbiol

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In this study, the physio pathological effects of Aspergillus alliaceus (Aa, fungi, biocontrol agent) on Orobanche (parasitic plant) were investigated by hormone and phenolic substance tests. In experimental group, Orobanches were treated with the fungi, considering control group was fungus-free. Based on the hormonal tests, in the experimental group, salicylic acid (SA), jasmonic acid (JA), abscisic acid (ABA) and gibberellic acid (GA) levels significantly decreased, and only indole acetic acid (IAA) hormone levels were fairly higher than the control group. According to phenolic substance tests, it was found that only gallic acid, syringic acid and caffeic acid values significantly increased compared with control, and catechin and p-coumaric acid values were significantly lower. Consequently, it was determined that Aa pathogenesis (1) considerably reduces the effects of all defence hormones (JA, ABA, SA), (2) operates an inadequate defence based solely on the IAA hormone and several phenolic substances (gallic acid, syringic acid and caffeic acid), (3) and inevitably the fungi lead the Orobanche to a slow and continuous death. The results were evaluated in detail in the light of similar recent article and current literature in terms of biocontrol and pathology.

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p‐Coumaric acid improves oxidative and osmosis stress responses in Caenorhabditis elegans

Abstract: Taken together, our results suggest that p-coumaric acid, an antioxidant agent, ameliorated oxidative and osmosis stresses in C. elegans. © 2018 Society of Chemical Industry.

Cited by 35 publications

References 40 publications

Protective Effect of p-Coumaric Acid as Free Oxygen Radical Scavenger in Experimental Renal Ischemia-Reperfusion Model

Protective Effect of p-Coumaric Acid as Free Oxygen Radical Scavenger in Experimental Renal Ischemia-Reperfusion Model

Butein inhibits lipogenesis in Caenorhabditis elegans

Aspergillus alliaceus infection fatally shifts Orobanche hormones and phenolic metabolism

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