Nao-Xue-Shu Oral Liquid Protects and Improves Secondary Brain Insults of Hypertensive Cerebral Hemorrhage

Abstract

Aim. To determine one traditional Chinese medicine (TCM) Nao-Xue-Shu oral liquid which protects and improves secondary brain insults (SBI) in hypertensive cerebral hemorrhage (HCH). Methods. 158 patients with HCH were divided into routine clinical medicine plus Nao-Xue-Shu oral liquid (n = 78) as treatment group, and routine clinical medicine (n = 80) only served as the control group. The incidence of SBI and the classification of a favorable prognosis and a bad prognosis using the Glasgow outcome scale (GOS) were assessed to evaluate the clinical effects. The changes of IL-6 and TNF-α levels were determined to study the mechanism of the effects for the TCM. Results. The incidence of SBI at the end of week 2 was 8.97% in the treatment group and 23.75% in the control group, and the difference was significant (P < 0.001). The incidence of a favorable prognosis was 48.72% in the treatment group and 32.72% in the control group, and the difference was significant (P < 0.01) at the end of week 2. These findings indicate clear differences for IL-6 and TNF-α at the end of week 1 and week 2 compared with before treatment for the treatment group and a marked difference at the end of week 2 between the two groups. It also shows a significant difference between the end of week 2 and before treatment for IL-6 and TNF-α for the control group, although the difference was much smaller than the treatment group. Conclusion. Nao-Xue-Shu oral liquid could protect against the occurrence of SBI and improve HCH and SBI patients. It may also decrease the damage and the mass effects of the hematoma by reducing IL-6 and TNF-α to obtain the effects, and thus it is a potentially suitable drug for HCH and SBI.

miR-7-5p Affects Brain Edema After Intracerebral Hemorrhage and Its Possible Mechanism

“…Studies on patients with brain injury showed that IL-6 levels were high within a few hours after brain injury and that they gradually decreased after 1-2 days (Woiciechowsky et al, 2002). One study on patients with ICH found that IL-6 and TNF-α levels decreased on day 14 (Jiang et al, 2016). In our study, IL-6 levels decreased on day 7, suggesting that the inflammatory response mediated by IL-6 had gradually reduced on day 7 after ICH.…”

The Pathophysiological Mechanism and Treatment of Secondary Brain Insult of Hypertensive Intracerebral Hemorrhage

“…However, clinical treatments for SBI after HICH are in the hysteretic stage, so it is urgent to explore effective methods. Recently, a study found that Nao-Xue-Shu oral liquid has a markedly lower incidence of SBI, inhibits the accumulation of hematoma, improves the absorbance of hemorrhage, eliminates the toxic stimulation of peripheral brain tissue, and inhibits the accumulation of inflammatory factors [28]. Chinese medicine has the distinctive function of modulating the body or dealing with diseases, including the treatment of brain problems [29,30].…”

Treatment of Naoxueshu Promotes Improvement of Hematoma Absorption and Neurological Function in Acute Intracerebral Hemorrhage Patients

“…In addition, astragalus can also protect the blood-brain barrier permeability, perform antioxidation, and prevent cerebral ischemia (Liu et al, 2012 ; Wang et al, 2013 ; Cai et al, 2014 ). Previous studies found that Naoxueshu oral liquid could improve aphasia in mixed stroke patients (Yan et al, 2015 ) and it could also protect against the occurrence of secondary brain insults and hypertensive cerebral hemorrhage (Jiang et al, 2016 ). Whether it could be useful in the treatment of ICH is still unknown.…”