miR-7-5p Affects Brain Edema After Intracerebral Hemorrhage and Its Possible Mechanism

Chen, Xiqian; Deng, Shuwen; Qiang, Lei; He, Qiang; Ren, Yijun; Zhang, Yiliu; Nie, Jingjing; Lu, Wei

doi:10.3389/fcell.2020.598020

Cited by 16 publications

(14 citation statements)

References 52 publications

(71 reference statements)

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“…Previously, we confirmed that the neuroprotective effect of NBP may be related to inhibiting the expression of TNF-α and MMP-9, and down-regulating oxidative stress and DNA damage after ICH 18 . Meanwhile, other studies suggested that NBP can up-regulated the expression of VEGF and angiopoietins-2 (Ang-2) proteins 36 , and decreased the expression of AQP4 37 . Collectively, the cellular and molecular mechanism of NBP protection in ICH includes promoting neovascularization, attenuating inflammation response, and decreasing brain edema.…”

Section: Discussionmentioning

confidence: 99%

L-3-n-butylphthalide promotes restoration after an experimental animal model of intracerebral hemorrhage

Jianyang

Xiao

2021

Int. J. Med. Sci.

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Intracerebral hemorrhage (ICH) is a devastating type of stroke with high morbidity and mortality, and the effective therapies for ICH remain to be explored. L-3-n-butylphthalide (NBP) is widely used in the treatment of ischemic stroke. However, few studies evaluated the therapeutic effects of NBP on ICH. Therefore, the present study aims to evaluate the effects of NBP on ICH and its potential mechanism. The rats were randomly divided into sham-operated group, saline-treated (ICH + saline) group, and NBP-treated (ICH + NBP) group. The ICH model of SD rats induced by IV collagenase was established. The modified Garcia JH score was used to detect the neurological deficit in rats. Western Blot and immunohistochemistry analysis was applied to test the levels of UBIAD1 and caspase-3 expressions in the perihematomal region. The rates of apoptotic cells were detected by TUNEL staining. The results showed that NBP up-regulated the expression of UBIAD1, reduced the apoptotic cells in the perihematomal region, and improved the neurological deficit. Taken together, our study added some new evidence to the application of NBP in ICH treatment.

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Section: Discussionmentioning

confidence: 99%

L-3-n-butylphthalide promotes restoration after an experimental animal model of intracerebral hemorrhage

Jianyang

Xiao

2021

Int. J. Med. Sci.

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“… Zhang et al (2020b) observed that inhibition of the expression of AQP4 with glycyl-l-histidyl-l-lysine (GHK) could alleviate the injury of astrocytes and brain edema. Moreover, a different group also showed that AQP4 deletion reduced brain edema ( Chen et al, 2020 ).…”

Section: The Change In Aqp4 Expression After Strokementioning

confidence: 99%

The Glymphatic System: A Novel Therapeutic Target for Stroke Treatment

Zhao

et al. 2021

Front. Aging Neurosci.

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The glymphatic system (GS) is a novel defined brain-wide perivascular transit network between cerebrospinal fluid (CSF) and interstitial solutes that facilitates the clearance of brain metabolic wastes. The complicated network of the GS consists of the periarterial CSF influx pathway, astrocytes-mediated convective transport of fluid and solutes supported by AQP4 water channels, and perivenous efflux pathway. Recent researches indicate that the GS dysfunction is associated with various neurological disorders, including traumatic brain injury, hydrocephalus, epilepsy, migraine, and Alzheimer’s disease (AD). Meanwhile, the GS also plays a pivotal role in the pathophysiological process of stroke, including brain edema, blood–brain barrier (BBB) disruption, immune cell infiltration, neuroinflammation, and neuronal apoptosis. In this review, we illustrated the key anatomical structures of the GS, the relationship between the GS and the meningeal lymphatic system, the interaction between the GS and the BBB, and the crosstalk between astrocytes and other GS cellular components. In addition, we contributed to the current knowledge about the role of the GS in the pathology of stroke and the role of AQP4 in stroke. We further discussed the potential use of the GS in early risk assessment, diagnostics, prognostics, and therapeutics of stroke.

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“…It has also been proven as protective against ischemiareperfusion injury in in vivo rat models by some [49], and as aggravating by others [50]. A recent study demonstrated that miR-7-5p was decreased in the serum of patients suffering from hemorrhagic stroke [51]. Should the results extrapolated from rats be accurate, this would mean a diminished inhibition the PI3K/AKT pathway, leading to an increase of aquaporin 4 (AQP4) within the brain edema area caused by the hemorrhage.…”

Section: Mir-7-5pmentioning

confidence: 99%

An Insight into the microRNAs Associated with Arteriovenous and Cavernous Malformations of the Brain

Florian

Buruiană

Şuşman

et al. 2021

Cells

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Background: Brain arteriovenous malformations (BAVMs) and cerebral cavernous malformations (CCMs) are rare developmental anomalies of the intracranial vasculature, with an irregular tendency to rupture, and as of yet incompletely deciphered pathophysiology. Because of their variety in location, morphology, and size, as well as unpredictable natural history, they represent a management challenge. MicroRNAs (miRNAs) are strands of non-coding RNA of around 20 nucleotides that are able to modulate the expression of target genes by binding completely or partially to their respective complementary sequences. Recent breakthroughs have been made on elucidating their contribution to BAVM and CCM occurrence, growth, and evolution; however, there are still countless gaps in our understanding of the mechanisms involved. Methods: We have searched the Medline (PubMed; PubMed Central) database for pertinent articles on miRNAs and their putative implications in BAVMs and CCMs. To this purpose, we employed various permutations of the terms and idioms: ‘arteriovenous malformation’, ‘AVM’, and ‘BAVM’, or ‘cavernous malformation’, ‘cavernoma’, and ‘cavernous angioma’ on the one hand; and ‘microRNA’, ‘miRNA’, and ‘miR’ on the other. Using cross-reference search; we then investigated additional articles concerning the individual miRNAs identified in other cerebral diseases. Results: Seven miRNAs were discovered to play a role in BAVMs, three of which were downregulated (miR-18a, miR-137, and miR-195*) and four upregulated (miR-7-5p, miR-199a-5p, miR-200b-3p, and let-7b-3p). Similarly, eight miRNAs were identified in CCM in humans and experimental animal models, two being upregulated (miR-27a and mmu-miR-3472a), and six downregulated (miR-125a, miR-361-5p, miR-370-3p, miR-181a-2-3p, miR-95-3p, and let-7b-3p). Conclusions: The following literature review endeavored to address the recent discoveries related to the various implications of miRNAs in the formation and growth of BAVMs and CCMs. Additionally, by presenting other cerebral pathologies correlated with these miRNAs, it aimed to emphasize the potential directions of upcoming research and biological therapies.

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miR-7-5p Affects Brain Edema After Intracerebral Hemorrhage and Its Possible Mechanism

Cited by 16 publications

References 52 publications

L-3-n-butylphthalide promotes restoration after an experimental animal model of intracerebral hemorrhage

L-3-n-butylphthalide promotes restoration after an experimental animal model of intracerebral hemorrhage

The Glymphatic System: A Novel Therapeutic Target for Stroke Treatment

An Insight into the microRNAs Associated with Arteriovenous and Cavernous Malformations of the Brain

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