<i>Kigelia africana</i> fruit: Constituents, bioactivity, and reflection on composition disparities

Osman, Ahmed Galal; Ali, Zulfiqar; Chittiboyina, Amar G.; Khan, Ikhlas A.

doi:10.4103/wjtcm.wjtcm_15_17

Cited by 11 publications

(11 citation statements)

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“…Both the extracts were active against Trypanosoma brucei. The ethyl acetate fraction of the extracts showed similar activity against all the organisms (Khan et al, 2017).…”

Section: Anti Leishmanial Activitymentioning

confidence: 76%

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Kigelia africana (Lam.) Benth: Sausage of Medicinal Properties

Jubilee

Komala

2021

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Nature had been serving humanity from ages by providing with the food and resources of our well-being. It was serving with medicines and herbs that are used to heal many disorders. There were numerous lead molecules that had been isolated from natural sources, especially plants. Kigelia africana (Lam.) Benth is a widely distributed plant in Africa. Savage tree or the cucumber plant is the common name of the plant. It belongs to the family Bignoniaceae. The plant is a native plant of Africa which is confined to the south, central and West African regions. Preliminary phytochemical screening was performed for the plant revealed the presence of alkaloids, tannins, saponins, flavonoids, carbohydrates and sapogenetic glycosides. The plant has been reported to contain flavonoids, aldehyde iridioids, coumarins like dihydroisocoumarin, naphthoquinones like pinnatal, isopnnatal, kigelinole and isokigelinole. It had been investigated and proven to possess various chemicals that treat inflammations, cancers, psoriasis, dysentery and bacterial infections.

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“…Both the extracts were active against Trypanosoma brucei. The ethyl acetate fraction of the extracts showed similar activity against all the organisms (Khan et al, 2017).…”

Section: Anti Leishmanial Activitymentioning

confidence: 76%

“…Apart from caffeic acid, it also was elucidated for chlorogenic acid and furanone derivatives like ajugol (Gouda et al, 2003). Compounds like iridiods, phenylpropanoid derivative and eucommiol derivatives were isolated from the plant (Khan et al, 2017).…”

Section: Chemical Constituentsmentioning

confidence: 99%

Kigelia africana (Lam.) Benth: Sausage of Medicinal Properties

Jubilee

Komala

2021

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“…However, not more than 10 compounds were identified in these previous works [41,42]. In addition, a very recent work demonstrated that such constituents change depending on the cultivation region of the plant [5]. In the present research, a total of 17 phenol-like compounds were detected and are reported in Table 2, along with the detected ions (deprotonated molecules for the majority of the assigned structures, but also sodium or potassium adducts were found), by using complementary information coming from negative and positive ionization.…”

Section: Phenol-like Compoundsmentioning

confidence: 97%

“…The biological properties of K. africana are mainly related to the presence of antioxidant molecules, such as iridoids, flavonoids, coumarins and quinones, already reported in the literature [5,7,[37][38][39][40].…”

Section: Phenol-like Compoundsmentioning

confidence: 99%

“…It is also known as cucumber or sausage tree due its huge fruits (roughly 0.6 m in length and 4 kg in weight) originating from long fibrous stalks [4]. The fruits are the part used in traditional medicine and are frequently used for infertility treatments, anti-tumor activity, for fungal and bacterial infections, diabetes, and anti-inflammatory processes [5]. Also, the fruit extracts have proved to possess antioxidant activity, which could drive the treatment of liver-borne disease [6].…”

Section: Introductionmentioning

confidence: 99%

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Exploration of Rapid Evaporative-Ionization Mass Spectrometry as a Shotgun Approach for the Comprehensive Characterization of Kigelia Africana (Lam) Benth. Fruit

et al. 2020

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Rapid evaporative-ionization mass spectrometry (REIMS) coupled with an electroknife as a sampling device was recently employed in many application fields to obtain a rapid characterization of different samples without any need for extraction or cleanup procedures. In the present research, REIMS was used to obtain a metabolic profiling of the Kigelia africana fruit, thus extending the applicability of such a technique to the investigation of phytochemical constituents. In particular, the advantages of REIMS linked to a typical electrosurgical handpiece were applied for a comprehensive screening of this botanical species, by exploiting the mass accuracy and tandem MS capabilities of a quadrupole-time of flight analyzer. Then, 78 biomolecules were positively identified, including phenols, fatty acids and phospholipids. In the last decade, Kigelia africana (Lam.) Benth. fruit has attracted special interest for its drug-like properties, e.g., its use for infertility treatments and as anti-tumor agent, as well as against fungal and bacterial infections, diabetes, and inflammatory processes. Many of these properties are currently correlated to the presence of phenolic compounds, also detected in the present study, while the native lipid composition is here reported for the first time and could open new directions in the evaluation of therapeutic activity.

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