Among the natural sources, plant origin drugs constitute around 25% which includes various secondary metabolites such as bioflavonoids, alkaloids, terpenes, saponins, glucosides, and lignans. The bioflavonoids belonging to the polyphenol group shows many beneficial effects like hepatoprotective, antioxidant, antibacterial, anticancer, anti-inflammatory and antiviral. The main objective of this article is to collectively present the research data published worldwide about the anticancer activity of bioflavonoids by loading them in novel formulations. Thus, the present review explored the novel formulations of the bioflavonoids with improved pharmacokinetic properties along with the enhanced anticancer activity. The major drawback with bioflavonoids is its poor solubility and bioavailability, which restricts the usage of bioflavonoids in the treatment of cancer in the market worldwide. Novel drug delivery system seems to possess many benefits like site-specific drug delivery along with minimal side effects and improves pharmaceutical and therapeutic properties of drugs compared to a conventional dosage form of bioflavonoids. The scope for improvement of anticancer activity of bioflavonoids by incorporating in novel pharmaceutical formulations like nanoparticles is very high, and it has to be considered as a potential area of research.
Phytochemicals produced by herbs and medicinal plants have a variety of therapeutic uses. They also help the plant's colour and organoleptic characteristics. Due to their absence of adverse effects, these phytochemicals are used in advanced medical systems to efficiently treat ailments. Because Kigelia Africana contains phytoconstituents, the plant has gained significant scientific attention for its wide range of pharmacological properties. It has been examined and shown to have a number of compounds that treat cancer, psoriasis, dysentery, inflammations, and bacterial infections. The goal of the current investigation was to identify and separate the chemical components found in the fruit extracts of Kigelia africana (Lam.) Benth. Preliminary phytochemical screening performed on n-hexane, chloroform, ethyl acetate, ethanol and aqueous extracts showed the presence of alkaloids, glycosides, phenols, flavonoids etc. The qualitative estimation of the phytoconstituents revealed the presence of total phenols, total flavonoids, total saponins and glycosides as 9.38, 2.64, 3.12 and 6.45 %w/w respectively in the ethanol extract. The ethanol extract was subjected to TLC and coloumn chromatography which resulted in 4 fractions out of which fraction F4 was in significant quantity. It was analyzed using HPTLC that showed the presence of one isolated molecule.
Periodontal diseases is a world wide prevalent chronic infection, which is caused by accumulation of specific microorganism or group of microorganisms in dental plaque, which results in the progressive loss of bone around teeth leading to loss of teeth. The present study was developed and evaluated in situ gelling system of Lomefloxacin hydrochloride by using different concentrations of Carbopol 934 for treatment of periodontitis. The drug-polymer compatibility were study using DSC. The seven formulation (L1 to L7) were prepared and their appearance, pH, viscosity, gelling capacity, %drug content, syringeability and in vitro drug release were investigated. The findings of compatibility study indicates that the drug was compatible with polymer. The developed formulations showed satisfactory results for pH, viscosity, gelling capacity, %drug content, syringeability and in vitro drug release. Based on maximum desirability and cost effectiveness formulation L7 with 1.0 % of polymer Carbopol 940, showed a sustained release of drug for 16 hrs.
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