<i>In vivo</i> skin elastography with high‐definition optical videos

Zhang, Yong; Mostow, Eliot N.; Vinyard, Christopher J.; Marie, Hazel

doi:10.1111/j.1600-0846.2009.00351.x

Cited by 18 publications

(12 citation statements)

References 22 publications

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“…19,20 In addition to the aforementioned methods, quantification of skin elasticity and wrinkling can also be performed using a noninvasive suction device (cutometer), profilometry, and optical skin elastography. [21][22][23][24][25] Our preliminary results suggest that noninvasive skin imaging methods such as OCT and HFUS seem be suitable techniques for the evaluation of elastolytic skin disorders such as MDE, anetoderma and cutis laxa syndromes. 1,16 OCT and HFUS may represent useful tools for the quantification and monitoring of disease severity in elastolytic conditions.…”

Section: Reportmentioning

confidence: 83%

“…Moreover, OCT elastography has been reported to be an attractive technique for evaluating the mechanical properties of tissues 19,20 . In addition to the aforementioned methods, quantification of skin elasticity and wrinkling can also be performed using a noninvasive suction device (cutometer), profilometry, and optical skin elastography 21–25 …”

Section: Reportmentioning

confidence: 99%

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Non-invasive imaging of mid-dermal elastolysis

Scola

Goulioumis

Gambichler

2011

Clinical and Experimental Dermatology

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Mid-dermal elastolysis (MDE) is a rare disease that is characterized histopathologically by selective loss of elastic tissue in the mid dermis. We aimed to assess MDE using noninvasive skin imaging techniques in vivo. We examined both the lesional and adjacent healthy skin of a woman with the reticular variant of MDE, using confocal scanning laser microscopy, optical coherence tomography (OCT) and high-frequency ultrasound (HFUS). The median diameter of blood vessels at the top of dermal papillae was significantly increased in erythematous lesional skin compared with healthy skin. The mid-dermal signal intensity detected by OCT was higher in healthy skin than in lesional skin. With HFUS, mid-dermal density values were significantly higher in healthy skin than in lesional skin. Our preliminary findings indicate that noninvasive skin imaging methods such as OCT and HFUS might be suitable techniques for the evaluation and monitoring of elastolytic skin disorders such as MDE.

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Section: Reportmentioning

confidence: 83%

Section: Reportmentioning

confidence: 99%

Non-invasive imaging of mid-dermal elastolysis

Scola

Goulioumis

Gambichler

2011

Clinical and Experimental Dermatology

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“…The biomechanical properties of human skin are of great significance for many reasons including their contribution to the function and structural integrity of the integument [1], their influence on the appearance of aging [2][3][4], and their role indicating disease and pathologies [5,6]. As a result of this significance, the biomechanical properties of skin have been studied and measured in a wide variety of fields such as biomedical engineering, forensics, cosmetology, the personal care product industry, and surgery [7][8][9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Measurement of the force–displacement response of in vivo human skin under a rich set of deformations

Flynn

Taberner

Nielsen

2011

Medical Engineering & Physics

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“…Precise mechanical properties of the skin tissue are helpful to capture the location and direction-dependent mechanical properties of the skin tissue (Groves et al 2013). The biomechanical properties of the human skin are of vital importance for many areas, including their contribution to the function and structural integrity of the integument (Silver et al 1992), their influence on the appearance of aging (Jenkins 2002;Kuwazuru et al 2008;Boyer et al 2012), and their role indicating disease and pathologies (Tilleman et al 2004;Zhang et al 2009). …”

Section: Introductionmentioning

confidence: 98%

Determination of the axial and circumferential mechanical properties of the skin tissue using experimental testing and constitutive modeling

Karimi

Navidbakhsh

Haghighatnama

et al. 2014

Computer Methods in Biomechanics and Biomedical Engineering

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The skin, being a multi-layered material, is responsible for protecting the human body from the mechanical, bacterial, and viral insults. The skin tissue may display different mechanical properties according to the anatomical locations of a body. However, these mechanical properties in different anatomical regions and at different loading directions (axial and circumferential) of the mice body to date have not been determined. In this study, the axial and circumferential loads were imposed on the mice skin samples. The elastic modulus and maximum stress of the skin tissues were measured before the failure occurred. The nonlinear mechanical behavior of the skin tissues was also computationally investigated through a suitable constitutive equation. Hyperelastic material model was calibrated using the experimental data. Regardless of the anatomic locations of the mice body, the results revealed significantly different mechanical properties in the axial and circumferential directions and, consequently, the mice skin tissue behaves like a pure anisotropic material. The highest elastic modulus was observed in the back skin under the circumferential direction (6.67 MPa), while the lowest one was seen in the abdomen skin under circumferential loading (0.80 MPa). The Ogden material model was narrowly captured the nonlinear mechanical response of the skin at different loading directions. The results help to understand the isotropic/anisotropic mechanical behavior of the skin tissue at different anatomical locations. They also have implications for a diversity of disciplines, i.e., dermatology, cosmetics industry, clinical decision making, and clinical intervention.

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In vivo skin elastography with high‐definition optical videos

Cited by 18 publications

References 22 publications

Non-invasive imaging of mid-dermal elastolysis

Non-invasive imaging of mid-dermal elastolysis

Measurement of the force–displacement response of in vivo human skin under a rich set of deformations

Determination of the axial and circumferential mechanical properties of the skin tissue using experimental testing and constitutive modeling

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