Measurement of the force–displacement response of in vivo human skin under a rich set of deformations

Flynn, Cormac; Taberner, Andrew J.; Nielsen, Poul M. F.

doi:10.1016/j.medengphy.2010.12.017

Cited by 75 publications

(37 citation statements)

References 41 publications

(46 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…19 To summarize, the probe of the micro-robot applied a rich set of three-dimensional deformations to the skin surface at different points of the arms of 21 volunteers (Fig. 1).…”

Section: In Vivo Experimental Databasementioning

confidence: 99%

Modeling the Mechanical Response of In Vivo Human Skin Under a Rich Set of Deformations

2011

Self Cite

View full text Add to dashboard Cite

Determining the mechanical properties of an individual's skin is important in the fields of pathology, biomedical device design, and plastic surgery. To address this need, we present a finite element model that simulates the skin of the anterior forearm and posterior upper arm under a rich set of three-dimensional deformations. We investigated the suitability of the Ogden and Tong and Fung strain energy functions along with a quasi-linear viscoelastic law. Using non-linear optimization techniques, we found material parameters and in vivo pre-stresses for different volunteers. The model simulated the experiments with errors-of-fit ranging from 13.7 to 21.5%. Pre-stresses ranging from 28 to 92 kPa were estimated. We show that using only in-plane experimental data in the parameter optimization results in a poor prediction of the out-of-plane response. The identifiability of the model parameters, which are evaluated using different determinability criteria, improves by increasing the number of deformation orientations in the experiments.

show abstract

“…19 To summarize, the probe of the micro-robot applied a rich set of three-dimensional deformations to the skin surface at different points of the arms of 21 volunteers (Fig. 1).…”

Section: In Vivo Experimental Databasementioning

confidence: 99%

Modeling the Mechanical Response of In Vivo Human Skin Under a Rich Set of Deformations

2011

Self Cite

View full text Add to dashboard Cite

show abstract

“…Dynamic system identification requires a deterministic control and measurement environment. Modifications to the device described by Flynn et al [9,28,29] included moving the timing control from the Microsoft Windows environment to LABVIEW 2011 REALTIME software (National Instruments, Austin, TX). Microrobot control signals and measurements were made on a compactRIO FPGA-based system (cRIO-9022 and cRIO-9114, National Instruments) running LABVIEW 2011 REALTIME software.…”

Section: Methodsmentioning

confidence: 99%

Multidirectional In Vivo Characterization of Skin Using Wiener Nonlinear Stochastic System Identification Techniques

Parker

Jones

Hunter

et al. 2016

Journal of Biomechanical Engineering

View full text Add to dashboard Cite

A triaxial force-sensitive microrobot was developed to dynamically perturb skin in multiple deformation modes, in vivo. Wiener static nonlinear identification was used to extract the linear dynamics and static nonlinearity of the force-displacement behavior of skin. Stochastic input forces were applied to the volar forearm and thenar eminence of the hand, producing probe tip perturbations in indentation and tangential extension. Wiener static nonlinear approaches reproduced the resulting displacements with variances accounted for (VAF) ranging 94-97%, indicating a good fit to the data. These approaches provided VAF improvements of 0.1-3.4% over linear models. Thenar eminence stiffness measures were approximately twice those measured on the forearm. Damping was shown to be significantly higher on the palm, whereas the perturbed mass typically was lower. Coefficients of variation (CVs) for nonlinear parameters were assessed within and across individuals. Individual CVs ranged from 2% to 11% for indentation and from 2% to 19% for extension. Stochastic perturbations with incrementally increasing mean amplitudes were applied to the same test areas. Differences between full-scale and incremental reduced-scale perturbations were investigated. Different incremental preloading schemes were investigated. However, no significant difference in parameters was found between different incremental preloading schemes. Incremental schemes provided depth-dependent estimates of stiffness and damping, ranging from 300 N/m and 2 Ns/m, respectively, at the surface to 5 kN/m and 50 Ns/m at greater depths. The device and techniques used in this research have potential applications in areas, such as evaluating skincare products, assessing skin hydration, or analyzing wound healing.

show abstract

“…This would be a powerful tool in surgery when planning the design of incisions to minimize adverse stress fields and reduce post-operative scarring at a specific location of the body [53]. So far, there are few studies centered on the mechanical behavior of skin based on the anatomical region [5,12,51], but no specific definition of their isotropic/anisotropic response were presented to address the directional mechanical properties of the skin tissue. Karimi et al performed a study on the linear elastic and nonlinear hyperelastic mechanical properties of rat skin at different anatomical locations [23,24].…”

Section: Introductionmentioning

confidence: 99%

Measurement of the axial and circumferential mechanical properties of rat skin tissue at different anatomical locations

Karimi¹,

Haghighatnama

Navidbakhsh³

et al. 2015

Biomedical Engineering / Biomedizinische Technik

View full text Add to dashboard Cite

Skin tissue is not only responsible for thermoregulation but also for protecting the human body from mechanical, bacterial, and viral insults. The mechanical properties of skin tissue may vary according to the anatomical locations in the body. However, the linear elastic and nonlinear hyperelastic mechanical properties of the skin in different anatomical regions and at different loading directions (axial and circumferential) so far have not been determined. In this study, the mechanical properties during tension of the rat abdomen and back were calculated at different loading directions using linear elastic and nonlinear hyperelastic material models. The skin samples were subjected to a series of tensile tests. The elastic modulus and maximum stress of the skin tissues were measured before the incidence of failure. The nonlinear mechanical behavior of the skin tissues was also computationally investigated through a constitutive equation. Hyperelastic strain energy density function was calibrated using the experimental data. The results revealed the anisotropic mechanical behavior of the abdomen and the isotropic mechanical response of the back skin. The highest elastic modulus was observed in the abdomen skin under the axial direction (10 MPa), while the lowest one was seen in the back skin under axial loading (5 MPa). The Mooney-Rivlin material model closely addressed the nonlinear mechanical behavior of the skin at different loading directions, which can be implemented in the future biomechanical models of skin tissue. The results might have implications not only for understanding of the isotropic and anisotropic mechanical behavior of skin tissue at different anatomical locations but also for providing more information for a diversity of disciplines, including dermatology, cosmetics industry, clinical decision making, and clinical intervention.

show abstract

Measurement of the force–displacement response of in vivo human skin under a rich set of deformations

Cited by 75 publications

References 41 publications

Modeling the Mechanical Response of In Vivo Human Skin Under a Rich Set of Deformations

Modeling the Mechanical Response of In Vivo Human Skin Under a Rich Set of Deformations

Multidirectional In Vivo Characterization of Skin Using Wiener Nonlinear Stochastic System Identification Techniques

Measurement of the axial and circumferential mechanical properties of rat skin tissue at different anatomical locations

Contact Info

Product

Resources

About