In vivo real-time tracking of tumor-specific biocatalysis in cascade nanotheranostics enables synergistic cancer treatment

Abstract

Herein, we described the strategy of cascade nanotheranostics for in real-time tracking of GOD release and thus provide the feedback information of biocatalysis cascade process with significantly enhanced in vivo therapeutic efficiency.

GSH‐Responsive Radiosensitizers with Deep Penetration Ability for Multimodal Imaging‐Guided Synergistic Radio‐Chemodynamic Cancer Therapy

“…Therefore, GSH consumption is a rational strategy to sensitize tumor cells to various therapeutic agents. [ 15–17 ] For example, GSH‐induced decomposition of manganese oxide (MnO) NPs leads to the release of paramagnetic Mn 2+ ions that are effective contrast agents for magnetic resonance imaging (MRI), and also mediate chemodynamic therapy (CDT) by triggering Fenton‐like reaction to generate high in situ levels of hydroxyl radicals (·OH). [ 18–20 ] Given the overall low efficacy of RT, it is rational to combine it with other therapeutic approaches such as CDT.…”

A single-atom Cu–N2catalyst eliminates oxygen interference for electrochemical sensing of hydrogen peroxide in a living animal brain

“…[6][7][8] As a representative of reactive oxygen species (ROS), the level of H 2 O 2 can be regulated by antioxidants such as glutathione peroxidase, catalase, thioredoxins and thiols to maintain the cellular redox homeostasis. 9,10 In addition, H 2 O 2 with a low physiological level can serve as an intracellular signaling molecule to regulate metabolism, enabling cellular adaption to the changes of stress and environment. 11,12 In contrast, overproduction of H 2 O 2 can break redox balance and thus cause oxidative stress, which is closely related with a variety of pathological events such as aging and progressive neurodegenerative disorders.…”

Enzyme/Nanocopper Hybrid Nanozymes: Modulating Enzyme-like Activity by the Protein Structure for Biosensing and Tumor Catalytic Therapy

“…For that purpose, enzymes with different natures, behaviors, and sizes were tested, with the ability to mimic particular enzyme activity completely different from the natural activity of the enzyme used as a scaffold, the highest tyrosinase-like activity, or even other oxidase activity in Fenton processes, 34 for catalysis, for example, applied in biocatalytic tumor therapy. 35 , 36 …”