<i>In vivo</i> EVALUATION OF PHOTOPROTECTION AGAINST CHRONIC ULTRAVIOLET‐A IRRADIATION BY A NEW SUNSCREEN MEXORYL® SX*

Fourtanier, Anny; Labat‐Robert, J.; Kern, Patrick; Berrebi, C.; Gracia, A. M.; Boyer, Brigitte

doi:10.1111/j.1751-1097.1992.tb04277.x

Cited by 41 publications

(32 citation statements)

References 36 publications

(25 reference statements)

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“…16 These absorbers have different absorption spectra, but were formulated so as to obtain a similar sun-protection factor (SPF). Human SPF values of the two preparations were 5.8 and 5.1, respectively.…”

Section: Evaluation Of the Efficiency Of Sunscreens Using An Organotymentioning

confidence: 99%

An organotypic model of skin to study photodamage and photoprotection in vitro

Bernerd

Asselineau

2008

Journal of the American Academy of Dermatology

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Section: Evaluation Of the Efficiency Of Sunscreens Using An Organotymentioning

confidence: 99%

An organotypic model of skin to study photodamage and photoprotection in vitro

Bernerd

Asselineau

2008

Journal of the American Academy of Dermatology

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“…5,[9][10][11] There have been many reports that the application of sunscreens before UV exposure inhibits the photoaging of skin in animal models and in humans. 8,[12][13][14][15][16] Based on those findings, application of a sunscreen before UV exposure might be expected to inhibit an increase in skin elastase activity even when UVA is continuously irradiated. It is therefore important and interesting to investigate the effects of chronic UVA irradiation on elastase activity in skin protected with sunscreens before irradiation in an animal model.…”

mentioning

confidence: 99%

The Effect of Sunscreen on Skin Elastase Activity Induced by Ultraviolet-A Irradiation

Tsukahara

Moriwaki

Hotta

et al. 2005

Biological & Pharmaceutical Bulletin

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To elucidate the mechanism underlying skin wrinkle formation, one feature of photoaging, we recently performed a study in which rat hind limb (plantar) skin was short-term chronically irradiated with ultraviolet-B (UVB) at 1 MED or lower. That study showed that elastase activity was increased in the rat hind limb skin 1) and changed the 3-dimensional structure of dermal elastic fibers, which bent the fibers responsible for skin elasticity 2,3) and thus decreased skin elasticity, forming wrinkles. 1,4,5) We also reported that this series of events could be inhibited by application of an elastase activity-inhibiting agent after UVB irradiation. 1,6,7) Inhibition of the UVB-induced increase in skin elastase activity prevented by the agent maintained the linearity of dermal elastic fibers and inhibited the decrease in skin elasticity, resulting in the inhibition of wrinkle formation. 1,6,7) This finding suggested that application of an elastase inhibitor immediately after UVB exposure would inhibit photoaging of the skin, mainly wrinkles.It has been shown that chronic UVB irradiation of the dorsal skin forms wrinkles in hairless mice 8,9) and that chronic ultraviolet-A (UVA) irradiation forms mainly sags. 8,9) In animal models, chronic UVA irradiation increased skin elastase activity and destroyed the 3-dimensional structure of dermal elastic fibers, decreasing skin elasticity, similarly to UVB irradiation.5,9-11) There have been many reports that the application of sunscreens before UV exposure inhibits the photoaging of skin in animal models and in humans. 8,[12][13][14][15][16] Based on those findings, application of a sunscreen before UV exposure might be expected to inhibit an increase in skin elastase activity even when UVA is continuously irradiated. It is therefore important and interesting to investigate the effects of chronic UVA irradiation on elastase activity in skin protected with sunscreens before irradiation in an animal model.The purpose of this study was to investigate effects of the photoprotection from UVA by topically applied sunscreens on skin elastase activity and on skin properties. MATERIALS AND METHODSAnimals Forty female HR/ICR hairless mice were used. This strain was derived by crossing 6 week old hairless mice (HR/HR) originally obtained from Nisseiken Corp (Tokyo, Japan) with the albino strain HaM/ICR. The HR/ICR strain represents a line maintained under clean conventional conditions in our laboratory by hairless brother/haired sister mating for several years. All experiments were performed with hairless female mice only, which had free access to food and water. They were housed in rooms where the lighting (without UVB emission) was automatically regulated on a 12 h light and dark cycle. The experimental protocol was approved by the Ethics Review Committee for Animal Experimentation of Kao Corp.UVA Irradiation UVA irradiation was carried out as described previously.9,10) Briefly, mice were irradiated using a bank of 12 Toshiba BL lamps with a glass filter (0.5 cm thick) for UVA (peak of...

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“…It has been shown to prevent UVA-induced histochemical alterations in skin associated with photoaging in animal models. 99 In human beings, Mexoryl SX applied before UVA exposure has been shown to prevent UV-induced changes, which include pigmentation, epidermal hyperplasia, decrease of skin hydration, and elasticity. 100 Sunscreen containing Mexoryl SX significantly suppressed UVRinduced carcinogenesis in mice compared with preparation containing UVB absorber alone.…”

Section: Uv Filters Topical Photoprotective Agentsmentioning

confidence: 99%