In vivo evaluation of bilayer ORC/PCL composites in a rabbit model for using as a dural substitute

Dural Reconstruction Materials for the Repairing of Spinal Neoplastic Cerebrospinal Fluid Leaks

“…We searched the keywords in databases to perform a co-occurrence analysis of dural and materials. Figure 67 porcine model Surgicel/Durasis/DuraGen/Preclude DuraGen dural substitute produced the least amount of inflammation and preclude generated the most, and Durasis demonstrated the least degree of inflammatory cell infiltration of the grafts that were not resorbed Deng et al 68 in vitro decellularized porcine small intestine/ polyester urethane-based Neuro-Patch dural substitute membranes showed cytocompatibility, did not provoke an inflammatory response, and maintained the stemness of hDPSCs better than mineral trioxide aggregate Ma et al 69 in vitro and rats/rabbit model bioresorbable poly(4-hydroxybutyrate) electrospun P4HB membranes have excellent biocompatibility without any foreign body response and the ability to form a continuous neodura tissue similar to native dura mater Huang et al 70 rabbit model photocross-linked hydrogel hydrogel can function as a dural substitute to repair dural defects in rabbits and reduce dural adhesion when compared with the null control Deng et al 51 in vitro and mice model chitin/bacterial cellulose substitutes showed suitable swelling rate and mechanical behavior without cytotoxicity effect, exhibited cell proliferation-promoting properties in vitro, and did not deform in the peritoneal environment of mice with mild tissue inflammation Li et al 42 in vitro and rabbit model fish collagen scaffold scaffold prevented brain tissue adhesion, reduced the possibility of inflammation in rabbit model, and can facilitate the growth of fibroblasts as well as enhance the tissue regeneration Chumnanvej et al 71 rabbit model oxidized regenerated cellulose (ORC)/ poly ε-caprolactone (PCL) knitted fabric composites both samples of rabbit model similarly exhibited biocompatibility and supported the dural regeneration without immunological rejection Sanpakitwattana et al 72 in vitro cefazolin-loaded ORC/PCL bilayered composite composite showed greater densities, but lower thickness, compared to those of drug unloaded composite, and cefazolin released from ORC/PCL bilayered composite was found to be monophasic, comprising mainly a burst release Seo et al 73 porcine model porcine pericardial graft porcine pericardial patch as a dural substitute has efficacy and safety as an alternative graft to use in duraplasty compared with a small intestinal submucosal graft EBC has a more dispersed and regular fiber structure, a better porosity and water holding capacity, and superior degradability compared with common bacterial cellulose; however, the biomechanical properties were slightly decreased Wang et al 75 in vitro nanofibrous substitutes nanofibrous substitutes could provide long-term structural support during the degradation, maintain a sustained release of IGF-1, promote neural cell survival and microenvironment of neurite growth, and play an important role in the neuroprotective effect after injuries Lama et al 49 rat model bacterial cellulose bacterial cellulose membrane showed suitable biocompatibility properties without immune reaction or chronic inflammatory response and neurotoxicity responses…”

Application Progress of Modified Chitosan and Its Composite Biomaterials for Bone Tissue Engineering

“…The success of biomaterial implantation depends highly on the implant’s macrophage polarization [ 38 ]. Macrophages are known to be involved in the in vivo biodegradation of resorbable polymers through the release of reactive oxygen intermediates, enzymes, and acids [ 39 ]. They also exert an immunomodulatory effect on osteogenic differentiation, inducing bone formation [ 40 , 41 ].…”

Duroplasty: Review of Materials and Techniques

“…провели in vitro та in vivo дослідження з нового двошарового матеріала з окисленої відновленої целюлози (ORC), просоченої розчином полі-ε-капролактона (PCL). Біомеханічні властивості матеріалу за характеристиками близькі до трупної ТМО [99], вивчення цитотоксичності матеріалу показало гарну біосумісність, з можливістю проростання фібробластів [100]. Експериментальне дослідження на кролях терміном до 6 місяців показало відсутність ліквореї та інфекційних ускладнень, можливість підтримувати регенерацію ТМО, порівнянну з використанням аутологічного матеріалу [101].…”