<i>In vivo</i> determination of skin surface topography using an optical 3D device

Jacobi, U.; Chen, Mai; Frankowski, Gottfried; Sinkgraven, Ronald; Hund, Martina; Rzany, Berthold; Sterry, Wolfram; Lademann, Jürgen

doi:10.1111/j.1600-0846.2004.00075.x

Cited by 111 publications

(96 citation statements)

References 24 publications

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“…The three-dimensional optical measurement of each replica was depicted using PRIMOS Compact (GF Messtechnik GmbH, Berlin, Germany), as previously reported. [52][53][54][55][56] After measurement, moiré fringes were eliminated, and an analytical straight line (7 to 9 mm) was drawn on each replica. Along this line, linear roughness parameter values were assessed.…”

Section: Skin Profilometric Measurementmentioning

confidence: 99%

Mechanistic Effects of Long-Term Ultraviolet B Irradiation Induce Epidermal and Dermal Changes in Human Skin Xenografts

Hachiya

Sriwiriyanont

Fujimura

et al. 2009

The American Journal of Pathology

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UVB irradiation has been reported to induce photoaging and suppress systemic immune function that could lead to photocarcinogenesis. However, because of the paucity of an UVB-induced photodamaged skin model, precise and temporal mechanism(s) underlying the deleterious effects of long-term UVB exposure on human skin have yet to be delineated. In this study, we established a model using human skin xenografted onto severe combined immunodeficient mice, which were subsequently challenged by repeated UVB irradiation for 6 weeks. Three-dimensional optical image analysis of skin replicas and noninvasive biophysical measurements illustrated a significant increase in skin surface roughness, similar to premature photoaging, and a significant loss of skin elasticity after long-term UVB exposure. Resembling authentically aged skin, UVB-exposed samples exhibited significant increases in epithelial keratins (K6, K16, K17), elastins, and matrix metalloproteinases (MMP-1, MMP-9, MMP-12) as well as degradation of collagens (I, IV, VII). The UVB-induced deterioration of fibrous keratin intermediate filaments was also observed in the stratum corneum. Additionally, similarities in gene expression patterns between our model and chronologically aged skin substantiated the plausible relationship between photodamage and chronological age. Furthermore , severe skin photodamage was observed when neutralizing antibodies against TIMP-1 , an endogenous inhibitor of MMPs , were administered during the UVB exposure regimen. Taken together , these findings suggest that our skin xenograft model recapitulates premature photoaged skin and provides a comprehensive tool with which to assess the deleterious effects of UVB irradiation.

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Section: Skin Profilometric Measurementmentioning

confidence: 99%

Mechanistic Effects of Long-Term Ultraviolet B Irradiation Induce Epidermal and Dermal Changes in Human Skin Xenografts

Hachiya

Sriwiriyanont

Fujimura

et al. 2009

The American Journal of Pathology

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“…Analysis of the status of human skin at different times, locations and at different scales provides an objective evaluation of factors like, ageing, and medical status as well as effectiveness of cosmetic treatments [1,2]. Important skin features like roughness or topography along with tactile properties, e.g.…”

Section: Introductionmentioning

confidence: 99%

“…friction and elasticity against a finger, are here important functional features to quantify for dermelogists and cosmetologists. Corcuff and Pierard [2] classify skin imaging according to their invasiveness and the thickness of the tissue removed for the analysis. Tape stripping can be used for the analysis of consecutive stratum corneum layers while biopsy or shave biopsy provides skin layers down to the hypodermis or in the latter case the papillary dermis.…”

Section: Introductionmentioning

confidence: 99%

Onin-vivoskin topography metrology and replication techniques

Rosén¹,

Blunt²,

Thomas³

2005

J. Phys.: Conf. Ser.

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On in-vivo skin topography metrology and replication techniques. Abstract. Human skin metrology is an area of growing interest for many disciplines both in research and for commercial purposes. Changes in the skin topography are an early stage diagnosis tool not only for diseases but also give indication of the response to medical and cosmetic treatment. This paper focuses on the evaluation of in vivo and in vitro methodologies for accurate measurements of skin and outlines the quantitative characterisation of the skin topography. The study shows the applicability of in-vivo skin topography characterisation and also the advantages and limitations compared to conventional replication techniques. Finally, aspects of stripe projection methodology and 3D characterisation are discussed as a background to the proposed methodology in this paper. Journal of Physics

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“…The RGB system was used to minimize errors caused by irregular light intensity of images. The computer-based image analysis was used to identify and quantify facial wrinkles, since it is less artefact prone and more accurate method than the commonly used silicon replica technique [11] [12].…”

Section: Facial Wrinkles Assessmentmentioning

confidence: 99%

Sleeping on an Anti-Wrinkle Pillow Reduces Facial Wrinkles: Results from an Anatomical Study

Poljšak¹,

Godić²,

Fink³

et al. 2015

FMAR

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Background: A special pillow was designed to redistribute mechanical stress during sleeping in order to slow down the formation of facial skin wrinkles. Objective: To investigate whether sleeping on a specially designed pillow reduces facial skin wrinkles. Participants and Methods: A 28-day pilot study was carried out in which fifteen healthy female volunteers aged 23 -55 years (mean age 35. 6 ± 8.5) slept on an antiwrinkle pillow. Evaluation of facial wrinkles was conducted before commencing the study (T0), following at 14 days (T14), and at 28 days (T28) when the study ended. Wrinkle density was assessed by computerized analysis of 2D images of participants' faces. Results: A statistically significant decrease in wrinkle density was detected while smiling around both eyes, around the right eye in a relaxed facial expression, on average in all observed facial areas, around the left periorbital area in participants who predominantly slept on their left side of the body, but not on the frontal area. Limitations: A 3D camera could be used to better visualize and analyze wrinkle density. Conclusions: Sleeping on the specially designed pillow reduces facial wrinkles.

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In vivo determination of skin surface topography using an optical 3D device

Cited by 111 publications

References 24 publications

Mechanistic Effects of Long-Term Ultraviolet B Irradiation Induce Epidermal and Dermal Changes in Human Skin Xenografts

Mechanistic Effects of Long-Term Ultraviolet B Irradiation Induce Epidermal and Dermal Changes in Human Skin Xenografts

Onin-vivoskin topography metrology and replication techniques

Sleeping on an Anti-Wrinkle Pillow Reduces Facial Wrinkles: Results from an Anatomical Study

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