In vitro Study of Five Herbs Used Against Microbial Infections in Burundi

Abstract

The emergence of antimicrobial resistant infectious diseases remains a major threat to worldwide public health, in developed and in developing countries. Therefore, new antimicrobial agents acting by new mechanisms of action are urgently needed. As plants used in traditional medicine may help to overcome these problems, Justicia subsessilis, Platostoma rotundifolium, Pavetta ternifolia, Stomatanthes africanus, and Virectaria major (plants highly cited to be used against microbial infections in traditional Burundian medicine) were studied to assess their traditional use efficacy. We conducted a preliminary phytochemical screening of the extracts, as well as their direct and indirect (effect on antibiotic resistance) antibacterial activity on four bacterial strains (Staphylococcus sp. and Escherichia coli) by broth microdilution methods. All five medicinal plants investigated in this work were found to have direct antibacterial activity against all tested bacterial strains (minimum inhibitory concentration = 62.5-1000 μg/mL) that may support the use of these species in traditional Burundian medicine. Extracts (with no direct antibacterial activity), tested at 200 μg/mL, decreased the MIC values of β-lactams and aminoglycoside antibiotics by a factor of 2 to 64-fold. These interactions between plant extracts and antibiotics could open an avenue of research against antibiotic resistance. Copyright © 2017 John Wiley & Sons, Ltd.

Antimicrobial Susceptibility Test for the Determination of Resistant and Susceptible S. aureus and Enterococcus spp. Using a Multi-Channel Surface Plasmon Resonance Device

“…Scholars have used different methods to investigate MRSA and VRE strains [32,33]. The most common method among these methods has been the broth microdilution method [34]. However, this method requires a longer testing time than our study.…”

Antimicrobial and Antiproliferative Activities of Vincetoxicum canescens subsp. canescens and Vincetoxicum cancescens subsp. pedunculata Seeds

“…Dahası yüksek maliyetli sentetik ilaçlar ve istenmeyen yan etkiler enfeksiyon hastalıkları ile etkili mücadelede farklı hareket mekanizmalarına sahip yeni antimikrobiyal ajanların keşfinin gerekliliğini ortaya koymaktadır. 3 Tıbbi bitkiler, bunlardan elde edilen ekstre ve bileşikler antioksidan, antimikrobiyal, antikanser, antienflamatuvar ve yara iyi edici etkileri nedeniyle birçok hastalığın tedavisinde alternatif tedavi stratejileri geliştirilmesine kaynak oluşturmaktadır. 4 Günümüzde birçok farmakolojik etki, düşük maliyet, elde edilebilirlik gibi özelliklere ek olarak yüksek etki ve düşük yan etki bitki ve bitkilerden elde edilen ürünlerin önemini daha da arttırmaktadır.…”

Evaluation of antimicrobial activity of five Vincetoxicum taxa growing in Turkey

“…Antimicrobial resistant strains lead to serious infections like urinary tract, pneumonia and bloodstream infections [1,2]. New antimicrobial agents with novel mechanisms of action are needed to fight effectively against infectious diseases [1].…”

“…Antimicrobial resistant strains lead to serious infections like urinary tract, pneumonia and bloodstream infections [1,2]. New antimicrobial agents with novel mechanisms of action are needed to fight effectively against infectious diseases [1]. This unmet need resulted from a variety of factors such as manufacturing synthetic agents with high costs, various adverse effects and ability to develop resistance to all classes of antimicrobial agents used against them [1,3,4].…”

“…New antimicrobial agents with novel mechanisms of action are needed to fight effectively against infectious diseases [1]. This unmet need resulted from a variety of factors such as manufacturing synthetic agents with high costs, various adverse effects and ability to develop resistance to all classes of antimicrobial agents used against them [1,3,4]. Nowadays, one of the most popular way of exploring new antimicrobial agents with low cost is to use medicinal plants as a source [4,5].…”