<i>In vitro</i>genotoxic effect evaluation of the<i>Nigella sativa</i>L. seed extract on human peripheral blood lymphocytes

Talbi, Hayat; Talha, Ibtissam; Amahdar, Loubna; Sbayou, Houda; Charaf, B.; Talbi, Jalal; Hilali, A.

doi:10.5958/0975-6892.2014.00019.7

Cited by 2 publications

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“…20,21 Genotoxicity assays in peripheral blood lymphocytes are highly useful for an initial evaluation of the side effects of chemical, physical, or biological agents. 22,23 Medicinal plants, generally lack scientific studies that determine their possible side effects. Plant species with abortive properties may pose a dual health risk due to their toxicity, potentially causing harm to both the mother and the embryo, and resulting in permanent damage.…”

Section: 15mentioning

confidence: 99%

Effect of Ambrosia tenuifolia Spreng on Danio rerio Embryo and Human Cells In Vitro

2024

TJNPR

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Ambrosia tenuifolia is a perennial herbaceous plant of the Asteraceae family, commonly used in Paraguay for multiple purposes as an abortive, antipyretic, digestive, and against headaches commonly in the form of an infusion of aerial parts. However, the lack of information on adverse effects raises questions about its safety and potential side effects. This study was undertaken to establish the potential health risks of A. tenuifolia for human health by evaluation of the aqueous and ethanolic extracts on Danio rerio embryos and to determine the potential toxicity or teratogenicity of the aqueous extract on human cells using human peripheral blood lymphocytes (PBL). For the test with D. rerio, observations were made 24 to 96 hours after fertilization. Coagulation, somite formation, heart rate, blood flow, pigmentation, edema formation, hatching, and spinal deviation were evaluated. As a result, the extract has lethal, sublethal, and teratogenic effects on the embryonic development of D. rerio, whose effects were dose-dependent. In the PBL, cells with and without bioactivation with the solution containing the S9 fraction were found to have genotoxic effects. This study provides the first report of toxicity and genotoxic effects of extracts of A. tenuifolia using D. rerio embryos and PBL after in vitro exposure.

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Section: 15mentioning

confidence: 99%

Effect of Ambrosia tenuifolia Spreng on Danio rerio Embryo and Human Cells In Vitro

2024

TJNPR

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In vitro toxicity, genotoxicity and antigenotoxicity of Nigella sativa extracts from different geographic locations

Nguyen

Talbi²,

Hilali³

et al. 2019

South African Journal of Botany

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In vitrogenotoxic effect evaluation of theNigella sativaL. seed extract on human peripheral blood lymphocytes

Cited by 2 publications

References 0 publications

Effect of Ambrosia tenuifolia Spreng on Danio rerio Embryo and Human Cells In Vitro

Effect of Ambrosia tenuifolia Spreng on Danio rerio Embryo and Human Cells In Vitro

In vitro toxicity, genotoxicity and antigenotoxicity of Nigella sativa extracts from different geographic locations

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