In vitroantioxidant activity andin vivowound-healing effect of lecithin liposomes: a comparative study

Abstract

Aim: This study was conducted to determine the potentials of egg lecithin (egg-l) and soy lecithin (soy-l) liposomes in antioxidative and wound healing properties. Materials & methods: The suspensions of egg-l and soy-l were prepared using the fusion technique. The free radical scavenging activity of both lecithin liposomes was evaluated by DPPH and ABTS methods. Tissue staining was used to assess wound-healing parameter. Results: Liposomal lecithins showed an increasing trend of 1–10 mg/ml in radical-scavenging activities (p < 0.0001). Wound-healing assessments showed a significant effect (p < 0.0001) in treatment with topical lecithin liposomes. The results of wound healing also showed better outcomes of egg-l in comparison with phenytoin 1% cream. Conclusion: Antioxidant lecithin liposomes may enhance the treatment of wound injuries.

RETRACTED: Therapeutic and Ameliorative Effects of Active Compounds of Combretum molle in the Treatment and Relief from Wounds in a Diabetes Mellitus Experimental Model

“…Reports on other treatment modalities have also been extensively studied. Hyperbaric oxygen therapy, electrical stimulation, and bioengineered skin are some of the other proven adjunct therapies in the treatment of diabetic foot ulcers [19].…”

Systematic Development and Characterization of Novel, High Drug-Loaded, Photostable, Curcumin Solid Lipid Nanoparticle Hydrogel for Wound Healing

“…Interestingly, the blank SLN gel also always showed significant healing comparable to the free curcumin gel ( p < 0.05) and to the marketed formulation at day 7 and 11 ( p < 0.05). This could be due to (i) the occlusive nature of SLNs which help to keep the wound moist, (ii) the film-forming nature of SLNs which may protect against the onslaught of pathogenic organisms, and (iii) the presence of 0.4 w / w % phosphatidyl choline in the SLN composition that has established antioxidant (1–10 mg/mL) and wound healing effects [ 71 ]. Oxidative stress is implicated as a deterrent to the wound healing process [ 72 ].…”

Targeting Tunable Physical Properties of Materials for Chronic Wound Care

“…Liposomes, also known as phospholipid vesicles, are the most widely used lipid NPs for wound dressings (Nasab et al, 2019). In contact with an aqueous solution liposomes can be automatically assembled into enclosed phospholipid bilayers containing a watery core surrounded by a hydrophobic membrane (Ahmed et al, 2019).…”

“…The lipid-based NPs versatile capabilities due to their nanoscales, biocompatibility, and high permeability might change our classical views on drugs pharmacokinetics. For example, egg lecithin and soy lecithin liposomes showed superior antioxidant activity in vitro and significantly accelerated woundhealing in vivo (Nasab et al, 2019). Reportedly, farnesylencapsulated liposomes promoted wound healing in a rat model with third-degree burns (Wu et al, 2019).…”