Synthesized titanium oxide nanoparticles (TiO2-NPs) nanotubes were used for the disinfection of new emerging corona virus-19 (SARS-CoV-2) in this study. The newly synthesized TiO2-NPs (nanotubes) were characterized by chemical spectroscopic analysis Fourier-transform infrared spectroscopy and ultraviolet FT-IR and UV. The chemical purity and Zeta potential distribution of the TiO2-NPs (nanotubes) were evaluated to confirm their nano-range, and their surface morphology was determined by scanning electron microscopy (SEM), transmission electron microscopy (TEM), high-resolution transmission electron microscopy (HR-TEM), and energy dispersive X-ray analysis (EDX). The antiviral activity of the TiO2-NPs (nanotubes) against SARS-CoV-2 was evaluated using 10% (Dimethyl sulfoxide) DMSO and dist.H2O using a cytotoxicity assay and inhibitory concentration assay (to determine the cytotoxic half concentration CC50 and half maximal inhibitory concentration IC50). The current results confirmed that TiO2-NPs exhibit strong anti-SARS-CoV-2 activity at very low cytotoxic concentrations in vitro with a non-significant selectivity index (CC50/IC50 ≤ 1). The obtained results indicate that TiO2-NPs and nanotubes have potent antiviral activity at a very low concentrations (IC50 = 568.6 ng/mL), with a weak cytotoxic effect on the cellular host (CC50 = 399.1 ng/mL). Thus, we highly recommend the use of TiO2-NPs (nanotubes) in vitro and in wall coatings as a potent disinfectant to combat SARS-CoV-2 with little irritation of the cellular hosts. Furthermore, we also recommend more and excessive prospective studies on the complexation of natural active or natural compounds with TiO2-NPs (nanotubes) to minimize their cytotoxicity, enhance their antiviral activity, and increase their inhibition of SARS-CoV-2.

Foot ulcers are one of the leading causes of severe and high mortality in diabetics. It is known that wound healing in diabetics is a very complicated process due to the direct severe effect of diabetes mellitus on blood vessels, causing difficulty in wound healing. Many methods of treatment have recently been employed for novel dressings for the promotion of tissue regeneration and rapid wound closure. Combretum molle is composed of chemical compounds, such as lignin, gallic acid, and ellagic acid. Twenty male rats that were 4 months of age were divided into a I-a diabetic foot ulcer group as the control group and a II-a diabetic group (wound + Combretum molle). This study investigated the antioxidant and excellent healing effects of the extract of Combretum molle in repairing skin damaged by diabetes. This was confirmed by elevated antioxidant enzymes in the animals’ tissues in diabetic rats treated with this extract. The recovery of the alterations in the skin layers led to great improvements, which proved the Combretum molle’s promising capacity for wound healing in diabetics with wounds that mimic diabetic foot ulcers. This treatment can be considered a promising opportunity for patients with severe foot ulcers and may open the door to more discoveries about this plant’s medical capabilities.

Fighting silent killer viruses like SARS-CoV2 is still a real challenge and the recent ability to predict whether human will fight a pandemic remains real challenge, but it is an urgent need to therapeutic strategy due to the appearance of novel deleterious influenza strains to cope with pandemics. The early diagnosis of these killing viruses are considered as very important steps in treatment and alleviating the severe symptoms of SARS-CoV2 viruses. Severe infections may be the cause of death especially due to liver , heart , renal and respiratory failure and in mean times encephalitis due to the severe fever in some cases of COVID-19 and failure of body organ to combat this SARS-CoV2 viral attack and so, we think that vitamin combination with the therapeutic protocol will be of very importance in saving organ vitality. The suggested protocol include treatment with potent anti-viral drugs combination (Favipiravir and acyclovir) which will display on inhibiting of viral RNA and can stop the uncontrolled replication of the virus and then using some potent immunostimulator and immunoprotectant factors like IgG and vitamin.D to provide the body either with ready immunoglobulins or elevate tight junctions of the tissues and improve vitality of the body. So we suggest this therapeutic option that we think it will achieve potent results and clinical trials are recommended to evaluate the efficacy of these drugs combination and their efficacy against COVID-19.

The journal retracts the article, “Therapeutic and Ameliorative Effects of Active Compounds of Combretum molle in the Treatment and Relief from Wounds in a Diabetes Mellitus Experimental Model [...]