Targeting Tunable Physical Properties of Materials for Chronic Wound Care

Abstract

Chronic wounds caused by infections, diabetes, and radiation exposures are becoming a worldwide growing medical burden. Recent progress highlighted the physical signals determining stem cell fates and bacterial resistance, which holds potential to achieve a better wound regeneration in situ. Nanoparticles (NPs) would benefit chronic wound healing. However, the cytotoxicity of the silver NPs (AgNPs) has aroused many concerns. This review targets the tunable physical properties (i.e., mechanical-, structural-, and size-related properties) of either dermal matrixes or wound dressings for chronic wound care. Firstly, we discuss the recent discoveries about the mechanical-and structural-related regulation of stem cells. Specially, we point out the currently undocumented influence of tunable mechanical and structural properties on either the fate of each cell type or the whole wound healing process. Secondly, we highlight novel dermal matrixes based on either natural tropoelastin or synthetic elastin-like recombinamers (ELRs) for providing elastic recoil and resilience to the wounded dermis. Thirdly, we discuss the application of wound dressings in terms of size-related properties (i.e., metal NPs, lipid NPs, polymeric NPs). Moreover, we highlight the cytotoxicity of AgNPs and propose the size-, dose-, and time-dependent solutions for reducing their cytotoxicity in wound care. This review will hopefully inspire the advanced design strategies of either dermal matrixes or wound dressings and their potential therapeutic benefits for chronic wounds.

Identification of key pathways and hub genes in the myogenic differentiation of pluripotent stem cell: a bioinformatics and experimental study

“…Mountainous efforts have been devoted to the research of pluripotent stem cells in our nowadays research for their regenerating and repairing damaged tissue effects [18][19][20]. In the musculoskeletal field, the degenerated and decreased muscle tissue has confused the clinical effects of various diseases [21,22].…”

Identification of key pathways and hub genes in the myogenic differentiation of pluripotent stem cell: A bioinformatics and experimental study

“…Mountainous efforts have been devoted to the research of pluripotent stem cells in our nowadays research for their regenerating and repairing damaged tissues effects. [18][19][20] In the musculoskeletal eld, the degenerated and decreased of muscle tissue have confused the clinical effects of various diseases. [21,22] The regeneration and remobilization of degenerated and damaged muscle tissues have been a hot issue in the research.…”

Modifications of Wound Dressings with Bioactive Agents to Achieve Improved Pro-Healing Properties

“…Chronic wounds are often associated with bacterial infections, which hinder the formation of new blood vessels. It leads to an imbalance between regulatory molecules involved in healing, impairs the entire process, and stops the tissue repair in one of the mentioned stages [6][7][8]. Most often, it is the prolonged inflammatory phase that is responsible for the chronic wound formation [9][10][11].…”