In-vitro antibacterial, antifungal and cytotoxic properties of sulfonamide—derived Schiff's bases and their metal complexes

Abstract

A series of new antibacterial and antifungal Schiff's bases derived from sulfonamides, as well as their transition metal complexes incorporating cobalt (II), copper (II), nickel (II) and zinc (II) were synthesized, characterized and screened for their in-vitro antibacterial activity against six Gram-negative (Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Pseudomonas aeruginosa, Salmonella typhi and Shigella dysentriae) and four Gram-positive (Bacillus cereus, Corynebacterium diphtheriae, Staphylococcus aureous and Streptococcus pyogenes) bacterial strains and for in-vitro antifungal activity against Trichophyton longifusus, Candida albicans, Aspergillus flavus, Microsporum canis, Fusarium solani, Candida glaberata. The results of these studies show the metal complexes to be more antibacterial and antifungal as compared to the uncomplexed Schiffs' bases. The brine shrimp bioassay was also carried out to study the in-vitro cytotoxic properties of these synthesized ligands and their complexes.

Template synthesis, spectroscopic studies and biological activities of macrocyclic complexes derived from thiocarbohydrazide and glyoxal

“…Besides this many other factors such as solubility, dipole moment, conductivity influenced by metal ion may be possible reasons for the remarkable antibacterial activities of these complexes [42]. It has also been observed that some moieties such as the azomethine linkage or heteroaromatic nucleus introduced into such compounds exhibit extensive biological activities that may be a result of the increase in hydrophobic character and liposolubility of the molecules in crossing the cell membrane of the microorganism and enhance the biological utilization ratio and activity of complexes [43]. …”

Synthesis of 5-amino-1,3,4-thiadiazole-2-sulphonamide derivatives and their inhibition effects on human carbonic anhydrase isozymes

“…The CO 2 -hydratase activity as an enzyme unit (EU) was calculated by using the equation ((t 0 _ t c )/t c ) where t 0 and t c were the times for pH change of the nonenzymatic and the enzymatic reactions, respectively. The IC 50 values (the concentration of inhibitor producing a 50% inhibition of CA activity) were obtained in vitro for the synthesised compounds (8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18), with 1 and 2 as the control compounds.…”

“…Furthermore the sulphonamides are the best-known inhibitors of the carbonic anhydrase enzyme, currently used for the treatment of glaucoma in clinical medicine [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20].…”

In vitro antileukemia, antibacterial and antifungal activities of some 3d metal complexes: Chemical synthesis and structure – activity relationships

“…Schiff bases H 2 L 1 -HL 7 obtained from interaction of salicyl aldehydes and appropriate amine were used as tridentate ligands containing ONO, ONS or ONN as donor atoms (Figure 1). Diamine L 8 , H 4 EDTA and H 5 DTPA were also used as ligands. The composition and structure of synthesized complexes were analysed by elemental analysis, IR and NMR spectroscopies, magnetochemical, thermoanalytical and molar conductance measurements.…”