A novel series of complexes of the type [M(TML)X 2 ]; where TML is Tetradentate Macrocyclic Ligand; M ¼ Co(II), Ni(II), Cu(II), Zn(II)or Cd(II); X ¼ Cl 2 , CH 3 COO 2 or NO 2 3 have been synthesized by template condensation of glyoxal and thiocarbohydrazide in the presence of divalent metal salts in methanolic medium. The complexes have been characterized by elemental analyses, conductance measurements, molecular weight determination, magnetic measurements, electronic, NMR, infrared and far infrared spectral studies. Electronic spectra along with magnetic moments suggest a six coordinate octahedral geometry for these complexes. The low molar conductance values indicates them to be non-electrolytes. The biological activities of the metal complexes have been tested in vitro against a number of pathogenic bacteria to assess their inhibitory potential.

A new series of complexes is synthesized by template condensation of glyoxal and oxalyldihydrazide in methanolic medium in the presence of divalent cobalt, nickel, copper, zinc and cadmium salts forming complexes of the type:3 ; OAc À1 . The complexes have been characterized with the help of elemental analyses, conductance measurements, magnetic susceptibility measurements, electronic, n.m.r., infrared and far infrared spectral studies. On the basis of these studies, a six coordinate octahedral geometry for these complexes has been proposed. The biological activities of the metal complexes have been tested in vitro against a number of pathogenic bacteria to assess their inhibiting potential. Most of the compounds have been found to exhibit remarkable antibacterial activities.

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A new series of macrocyclic complexes of the type [M(C 17 H 14 N 4 O 2 )X 2 ], where M = Co(II), Ni(II), Cu(II), Zn(II) or Cd(II) and X = Cl -, NO 3 -or CH 3 COO -, was synthesized by the condensation reaction of malonyldihydrazide with benzil in the presence of divalent metal ions. The complexes were characterized with the aid of elemental analyses, conductance measurements, magnetic susceptibilities, electronic, NMR and infrared spectral studies. On the basis of these studies, a six-coordinate distorted octahedral geometry, in which two nitrogen and two carbonyl oxygen atoms are suitably placed for coordination towards metal ion, is proposed for all the complexes. The complexes were tested for their in vitro antibacterial activity and antifungal activities. The minimum inhibitory concentration shown by these complexes were compared with the minimum inhibitory concentration shown by standard drugs.