In vitro and in vivo evaluation of liposomes modified with polypeptides and red cell membrane as a novel drug delivery system for myocardium targeting

Abstract

(2020) Invitro and in vivo evaluation of liposomes modified with polypeptides and red cell membrane as a novel drug delivery system for myocardium targeting,

Broad-Spectrum Theranostics and Biomedical Application of Functionalized Nanomaterials

“…Liposomes were reported to exert the best delivery capability with a prolonged mean residence time and enhanced accumulation in the heart. This suggests that liposomes could act as effective myocardial drug delivery systems and could help in various heart diseases including ischemic cardiac disease [ 36 ]. Krill oil, an omega-3 rich marine-derived oil, is effectively incorporated into liposomes (KO liposomes) and showed a high capacity to budesonide (BDS) entrapment in an intestinal bowel disease (IBD) drug.…”

Overcoming the cellular barriers and beyond: Recent progress on cell penetrating peptide modified nanomedicine in combating physiological and pathological barriers

“… Barriers CPP-NPs Sequence Functions Refs. Myocardial delivery PCM modified liposome WLSEAGPVVTVRALRGTGSW Prolong residence and accumulation in heart [ 91 , 92 ] Hph1–Hph1–dsRBD/siRNA complex Hph1: YARVRRRGPRR Enhance gene silencing effects [140] Lipoplexes modified with TAT and antimyosin antibody 2G4 RKKRRQRRR Increase accumulation in the ischemic rat myocardium [93] R7W-MP modified CaP NP DQRPDREAPRS Target the Cavb2 cytosolic subunit of the l -type calcium channel (LTCC), improve cardiac contractility in pathological conditions [94] TPSi NP RKKRRQRRR Increase both the cell survival rate and the delivery precision of stem cell transplantation [95] Ocular barrier POD-PEG NP GGGG(ARKKAAKA) 4 Target cell surface sialic acid. Reduce cell apoptosis and enhance the thickness of outer nuclear layer [141] POD-SS-PEG/DNA nanocomplex GGG[ARKKAAKA]4 Deliver FLT1 plasmid and achieve a 50% reduction in choroidal neovascularization in AMD model [142] POD conjugatedQD GGG[ARKKAAKA]4 Enter neural retina and localize to retinal pigment epithelium [143] Penetratin fused HDL mutants RQIKIWFQNRRMKWKK Enhance the delivery efficiency to the posterior segment of the eye [144] RFP plasmid /PAMAM/Penetratin RQIKIWFQNRRMKWKK Improve cellular uptake and transfection [102] cRGD/penetratin-PEG-PAMAM RQIKIWFQNRRMKWKK Deliver cargoes to the cornea and retina with a prolonged retention RGD/TAT-PEG-PLGA RKKRRQRRR Increase uptake in the choroid-retina …”

“…RCM-modified liposomes showed the highest cellular uptake and intracellular distribution on myocardial cells. After intravenous injection, RCM-modified liposomes significantly enhanced drug accumulation in the heart and prolonged the circulation time, representing an effective myocardium targeted drug delivery system [92] .…”

Recent Advances of Cell Membrane Coated Nanoparticles in Treating Cardiovascular Disorders

“…A number of novel nanocarriers have emerged ( Table 1 ), e.g., liposomes [ 62 , 63 ], gold nanoparticles [ 64 ], mesoporous silica nanoparticles [ 65 , 66 ], iron oxide nanoparticles[ 67 , 68 ], black phosphorous [ 69 , 70 , 71 ], PLGA nanoparticles [ 58 , 72 ], and layered double hydroxide [ 73 ]. These nanocarriers can either act as drug delivery platforms or as active components in themselves due to their intrinsic physical and chemical properties.…”