In vitroandin vivoantitumor activity of a methanol extract ofDregea volubilisleaves with its antioxidant effect

Hossain, Emdad; Chakroborty, Saikat; Milan, Ahmed; Chattopadhyay, Pronobesh; Mandal, Subhash C.; Gupta, Jayanta Kumar

doi:10.3109/13880209.2011.600320

Cited by 12 publications

(8 citation statements)

References 14 publications

(24 reference statements)

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“…Magnesium forms complex with oxalate and reduces the super saturation of calcium oxalate and as a consequence reduces the growth and nucleation rate of calcium oxalate crystals. Magnesium inhibits oxalate absorption and excretion and thus prevents its supersaturation [22] , [23] , [24] , [25] , [26] , [27] . Both the isolated compounds quercetin and betulin significantly increased the urinary magnesium level and thus reduce the risk of calcium oxalate stone formation.…”

Section: Discussionmentioning

confidence: 99%

Antiurolithiatic activity of natural constituents isolated from Aerva lanata

Dinnimath

Jalalpure

Patil

2017

Journal of Ayurveda and Integrative Medicine

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BackgroundPashanabheda is used as antiurolithiatic in Ayurveda. In the present study, Aerva lanata (L) Juss. ex. Schult (Amaranthaceae) from Western Ghats of India was selected for isolation of active constituents and screening for antiurolithiatic potentials.ObjectiveScreening of compounds isolated from A. lanata for antiurolithiatic potentials.Materials and methodsEthylene glycol (0.75% v/v) induced urolithiasis model was used to study the antiurolithiatic activity in male Wistar albino rats. The animals were divided into five groups containing six each. Based on the LD50 of the plant extract (2000 mg/kg b.w) equivalent dose was calculated from their yield. Two isolated compounds (quercetin and betulin) of A. lanata were screened for antiurolithiatic potentials in calculi induced (ethylene glycol 0.75% v/v) male Wistar albino rats by administering 2 mg/kg b.w/day orally as test dose for 28 days.ResultsThe urine volume was found to be significantly increased from 12.76 ± 0.10 ml to 21.35 ± 0.20 ml in the rats treated by quercetin and 21.50 ± 0.21 ml in rats treated by betulin. Urine microscopy revealed significant reduction (p < 0.001) in the size of calculi and significantly enhanced (p < 0.001) excretion of calcium, oxalate, phosphate, whereas the level of magnesium was increased. SEM of kidney sections has revealed reduction in the calculi in treated animals. Serum analysis has revealed significant reduction in the level of BUN and creatinine in treated rats.ConclusionThe isolated quercetin and betulin from A. lanata have shown mild diuretic effect as well as antiurolithiatic effect by significantly reducing the size of calculi in the kidneys and enhancing the excretion of calcium, phosphate, oxalate while maintaining the level of magnesium, which is reported to be one of the calculi inhibiting factors.

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Section: Discussionmentioning

confidence: 99%

Antiurolithiatic activity of natural constituents isolated from Aerva lanata

Dinnimath

Jalalpure

Patil

2017

Journal of Ayurveda and Integrative Medicine

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“…The in-vivo investigation demonstrated that methanolic extract treated rats at dosages of 50,100 and 200 mg/kg dramatically reduced tumour volume, packed cell volume and tumour cell count, as well as modifying haematological parameters to near normal levels 38 .…”

Section: Fasciocidal and Larvicidalmentioning

confidence: 96%

Untitled

2022

IJPSR

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Wattakaka volubilis (L. f) Stapf, belonging to the family of Asclepiadaceae, has a history of use in traditional medicine in numerous countries. Traditionally the plant has been used for the treatment of diabetes, eye infections, snake bites, boils, skin problems, jaundice etc. A tribal community called Kurinjan has been using this plant to reduce blood glucose level. This plant is a tall woody climber with ash-colored older branches and green or yellowish green flowers that fall in umbellate cymes. The review demonstrates that the plant has a large number of phytochemical elements with activities such as Anti-diabetic, Antioxidant, Anti-inflammatory, Analgesic, Antipyretic, Antitumour, Antimicrobial etc. The phytochemicals present are Alkaloids, Flavanoids, Tannins, Glycosides, Anthocyanidins. Phytochemicals such as Drevogenin, Delphinidine, Dregein, Dregeosides have been isolated from various parts of the plant. These findings are quite encouraging and suggest that this herb be researched further to validate these findings and uncover other possible therapeutic properties. Furthermore, the active chemical constituents of Wattakakka volubilis with significant pharmacological values must be isolated and evaluated.

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“…[23] The leaves and fruits extract of DV showed significant antitumor activity against Ehrlich ascites carcinoma in vivo. [15,16] Additionally, taraxerone, isolated from the fruit of DV, showed anti-cancer activity on K562 cell line. [14] As part of our ongoing research on bioactive compounds with potential for anti-cancer drug development, a chemical investigation was conducted on the twigs and leaves of DV.…”

Section: Introductionmentioning

confidence: 99%

“…Previous studies have demonstrated that extracts and compounds isolated from this plant exhibit anti‐tumor, [10,14–16] anti‐inflammatory, [17] hepatic protective, [18,19] anti‐diabetic, anti‐hyperlipidemic, [20,21] anti‐bacterial, anti‐fungal, [22] and anti‐parasitic activities [23] . The leaves and fruits extract of DV showed significant antitumor activity against Ehrlich ascites carcinoma in vivo [15,16] . Additionally, taraxerone, isolated from the fruit of DV , showed anti‐cancer activity on K562 cell line [14] …”

Section: Introductionmentioning

confidence: 99%

Identification and Cytotoxic Evaluation of Pregnane Saponins from the Twigs and Leaves of Dregea volubilis

Diep Vu,

Khoa Nguyen,

Thu Nguyen

et al. 2023

Chemistry & Biodiversity

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Four new polyhydroxy pregnane glycosides, named volubilosides G−K (3, 5–7), along with three known secondary metabolites, dregeoside Da1 (1), dregeoside Ka1 (2), and volubiloside E (4) were isolated from the twigs and leaves of Dregea volubilis (DV). The chemical structures of these compounds (1–7) were elucidated using spectroscopic techniques (1D and 2D NMR and HR‐ESI‐MS analyses) and compared with those in the published literature. Compounds (1–7) were evaluated for cytotoxicity against eight cancer cell lines (MB49, K562, MKN‐7, HT29, A549, MCF‐7, MDA‐MB‐231, and HepG2), revealing varying levels of cytotoxic effects with IC50 values ranging from 4.29 to 21.05 μM. The results indicated that compounds 1–7 may serve as potential lead compounds for the discovery and development of novel anti‐cancer drugs.

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In vitroandin vivoantitumor activity of a methanol extract ofDregea volubilisleaves with its antioxidant effect

Cited by 12 publications

References 14 publications

Antiurolithiatic activity of natural constituents isolated from Aerva lanata

Antiurolithiatic activity of natural constituents isolated from Aerva lanata

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Identification and Cytotoxic Evaluation of Pregnane Saponins from the Twigs and Leaves of Dregea volubilis

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