<i>In-vitro</i> Analysis for Microbial Barrier Properties of 2-Octyl Cyanoacrylate-Derived Wound Treatment Films

Narang, Upvan; Mainwaring, Lawrence; Spath, Gina; Barefoot, Joe

doi:10.1177/120347540300700103

Cited by 31 publications

(11 citation statements)

References 8 publications

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“…As they pointed out, this type of test is much more sensitive than an animal infection model, since penetration of one organism (1 cfu) would theoretically lead to a positive test, whereas logarithmically higher numbers of organisms would be required to establish an infection in an in vivo model due to the animals' inherent infection resistance/immune response. Narang et al 9 obtained similar results while performing their experiment in two different ways (also using Dermabond), either polymerizing the cyanoacrylate film directly on the agar as we did or using a preformed film in case the polymerization affected the agar (which it did not). Another agar plate method intended for a different application was used by Simonova et al 10 to test 2 cyanoacrylate adhesives (Dermabond, 2-octylcyanoacrylate; and Histoacryl ® , butylcyanoacrylate) for their ability to prevent the migration of microbes inoculated around catheters inserted in the agar at a 30° angle.…”

Section: Discussionsupporting

confidence: 66%

Effect on Microbial Growth of a New Skin Protectant Formulation

Stoffel¹,

Bernatchez

2017

Advances in Wound Care

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Objective: Evaluate the effect of a new investigational skin protectant formulation on the growth of various microorganisms in vitro.Approach: An in vitro laboratory assay with various species of gram-positive bacteria, gram-negative bacteria, and yeast grown on agar plates was used to verify that a new investigational product used for the management of incontinence-associated dermatitis (IAD) does not support microbial growth.Results: The investigational product did not support the growth of all organisms tested for 48 h in these assays. The results demonstrate the barrier properties of this investigational formulation against bacteria and yeast that are relevant to incontinent patients.Innovation: IAD accompanied by skin damage is difficult to manage with currently available products. A new skin protectant that can be applied as a liquid and polymerizes into a breathable film in situ even in the presence of exudate (as shown previously) has been developed and tested to ensure that it does not support microbial growth.Conclusion: This work verifies that this new product does not support microbial growth in vitro using organisms relevant for the intended application.

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Section: Discussionsupporting

confidence: 66%

Effect on Microbial Growth of a New Skin Protectant Formulation

Stoffel¹,

Bernatchez

2017

Advances in Wound Care

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“…They cure rapidly on skin surfaces within 5-60 s, sealing the wound instantly and providing a barrier against moisture. Although difficult to prove conclusively in vivo (116), there is in vitro evidence that cyanoacrylates provide a microbial barrier and are bacteriostatic (117). They are now routinely used in conjunction with, or as a replacement for sutures in topical surgical procedures and for bonding traumatized tissues in the emergency room (118).…”

Section: Cyanoacrylates In Medical Applicationsmentioning

confidence: 99%

Polycyanoacrylates

Burns

2016

Encyclopedia of Polymer Science and Technology

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Alkyl 2‐cyanoacrylate monomers are commonly used as instant adhesives or “superglue,” mainly because of their unique ability to undergo rapid polymerization under ambient conditions on a wide range of surfaces. This article overviews the chemistry and physical properties of these materials, the most common methods of preparation, their mode(s) of polymerization, and typical performance properties. The main performance limitations of alkyl 2‐cyanoacrylate adhesives, such as poor hot strength and resistance to extreme environments (high heat and humidity) are explained in terms of the susceptibility of the polymer to degradation, and how the chemical structure of the polymer directly affects this degradation process. An overview is given of how the performance properties of cyanoacrylate adhesives are modified through the inclusion of various thickeners for viscosity modification, accelerators for cure acceleration, and recent advances in two component cyanoacrylate adhesives. The uses of polycyanoacrylates in medical adhesive applications and for the preparation of nanoparticles for drug delivery are briefly reviewed.

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“…These films are flexible so that they do not crack, provide continuous coverage of the wound site, and they adhere strongly to the skin. [14] Our patients did not show any wound dehiscence which may indicate that the cyanoacrylate acts as a microbial barrier. This effect may have two possible explanations.…”

Section: Discussionmentioning

confidence: 69%

Evaluating the use of octyl-2-cyanoacrylate in unilateral cleft lip repair

Malhotra

Rao

Arya

et al. 2016

Natl J Maxillofac Surg

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Background:Facial cosmetic results are one of the most concerning issues for the parents who get their children operated for cleft lip. Moreover, the postoperative care of the surgical site, the discomfort associated with the suture removal, and additional visit for suture removal are other reasons which encourages one to use any new technologies that may replace the need for suture placement. In this study, we used octyl-2-cyanoacrylate, a tissue adhesive which offers a viable alternative to traditional techniques without compromising optimal wound closure.Objective:To perform a comprehensive comparison of the outcomes from the use of Dermabond in patients undergoing primary repair of congenital cleft lip ± palate anomalies.Materials and Methods:Twenty patients, in the age group of 3–18 months were treated surgically for unilateral cleft lip deformity using Millard rotation-advancement flap. Pre- and post-operative photographs of the patients were taken at 1 week, 2 week, 1 month, 6 months, and 1 year postoperatively and were evaluated using Vancouver scar scale which was given by Sullivan in 1990. Paired t-test was used for statistical analysis.Results:Increased vascularity (hyperemia) was seen in the 1st and 2nd week in 35% and 30% patients, respectively which gradually reduced to normal in subsequent follow-ups. The scar was flat in 85% of patients in 1st week, and the number decreased to 10% at the end of 1 year. No wound dehiscence was found in any patients. Statistical analysis showed that among all the follow-ups, only the difference between the first and second follow-ups. Comparison of the results of 1 week with all other follow-ups yielded no significant results.Conclusion:Octyl-2-cyanoacrylate can be used for cleft lip closure effectively. The procedure is relatively painless and quick. Added to this are benefits of protection from wound infection since the material is bacteriostatic.

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In-vitro Analysis for Microbial Barrier Properties of 2-Octyl Cyanoacrylate-Derived Wound Treatment Films

Abstract: 2-Octyl cyanoacrylate-based films are excellent microbial barriers.

Cited by 31 publications

References 8 publications

Effect on Microbial Growth of a New Skin Protectant Formulation

Effect on Microbial Growth of a New Skin Protectant Formulation

Polycyanoacrylates

Evaluating the use of octyl-2-cyanoacrylate in unilateral cleft lip repair

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