In situ product recovery of bio-based ethyl esters via hybrid extraction-distillation

Abstract

In situ product recovery (ISPR) of bio-based chemicals from microbial cultivation is a means to improve titer, rate, and yield because it alleviates end product inhibition.

Bioprocessing Separations Consortium Three-Year Overview: Technical Advances, Process Economics Influence, and State of the Science

“…Furthermore, the Consortium interfaces with several BETO consortia and projects including ChemCatBio (ChemCatBio 2020), Chemical Upgrading of Biological Intermediates (Elander et al 2019), Lignin-First Biorefinery Development (Beckham 2019), the Agile BioFoundry (Agile BioFoundry 2020), Co-Optima (EERE 2020), Performance Advantaged Bioproducts (Fitzgerald and Bailey 2018), and the Consortium for Computational Physics and Chemistry (CCPC 2020). The Consortium has multiple roles and objectives in these interfaces, including producing difficult-to-obtain purified products from crude mixtures for further processing, as well as evaluating and identifying cost-effective separations routes to target products of interest.…”

“…Experimental screening of more than 20 extractants found the best extractant for carboxylic acid recovery is the commercial phosphine oxide extractant Cyanex 923 because of its ability to form strong acid base pairs with the acidic protons on carboxylic acids (Saboe et al 2018). For esters, experimental screening found oleyl alcohol to be the most effective because its hydrostatic interaction with carbonyl functional groups in ester compounds is stronger (Saboe et al 2019).…”

Toward low-cost biological and hybrid biological/catalytic conversion of cellulosic biomass to fuels

“…However, this approach requires a significant amount of energy both for evaporation and to cool the large volumetric flowrate of gas utilized, and, instead, Hybrid Extraction Distillation– In Situ Product Recovery (HED-ISPR) systems are often more energetically favorable (discussed below), but are difficult to operate in slurry environments. 291 If the produced ester has a boiling point greater than that of water, direct phase separation approaches are the most attractive option. 291 However, this requires production at levels such that phase separation occurs, which to our knowledge has not yet been achieved.…”

“…291 If the produced ester has a boiling point greater than that of water, direct phase separation approaches are the most attractive option. 291 However, this requires production at levels such that phase separation occurs, which to our knowledge has not yet been achieved.…”

Bioprocessing Separations Consortium: Three-Year Overview. Technical advances, process economics influence, and State of the Science

“…Accordingly, bioprocessing separations are often a key driver of process costs and suffer from a lack of selectivity. Furthermore, the Consortium interfaces with several BETO consortia and projects including ChemCatBio (ChemCatBio 2020), Chemical Upgrading of Biological Intermediates (Elander et al 2019), Lignin-First Biorefinery Development (Beckham 2019), the Agile BioFoundry (Agile BioFoundry 2020), Co-Optima (EERE 2020), Performance Advantaged Bioproducts (Fitzgerald and Bailey 2018), and the Consortium for Computational Physics and Chemistry (CCPC 2020). The Consortium has multiple roles and objectives in these interfaces, including producing difficult-to-obtain purified products from crude mixtures for further processing, as well as evaluating and identifying cost-effective separations routes to target products of interest.…”