<i>In situ</i> formation of injectable hydrogels for chronic wound healing

Gao, Yunfen; Li, Zhen; Huang, Jun; Meng, Zhao; Wu, Jun

doi:10.1039/d0tb01074j

Cited by 122 publications

(75 citation statements)

References 100 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Chitin/nanosilver based scaffolds with exceptional antimicrobial activity have been fabricated for potential use in wound management. Furthermore, hydrogel systems based on polyvinyl pyrrolidone/alginate containing Cerium with efficient fluid handling capacity and antimicrobial activity have been developed for wound dressing applications (Hartwell et al, 2011;Tu et al, 2019;Xu et al, 2019;Gao et al, 2020). Chitin-covered CeNPs have also demonstrated promising wound management.…”

Section: Introductionmentioning

confidence: 99%

RETRACTED ARTICLE: Cerium oxide nanoparticle-loaded polyvinyl alcohol nanogels delivery for wound healing care systems on surgery

et al. 2021

View full text Add to dashboard Cite

This study was designed to establish the composition of wound bandages based on Cerium nanoparticle (CeNP)-loaded polyvinyl alcohol (PVA) nanogels. The CeNP nanogel (Ce-nGel) was fabricated by the fructose-mediated reduction of Cerium oxide solutions within the PVA matrix. The influences of different experimental limitations on PVA nanogel formations were examined. The nanogel particle sizes were evaluated by transmission electron microscopy and determined to range from $10 to 50 nm. Additionally, glycerol was added to the Ce-nGels, and the resulting compositions (Ce-nGel-Glu) were coated on cotton fabrics to generate the wound bandaging composite. The cumulative drug release profile of the Cerium from the bandage was found to be $38% of the total loading after two days. Additionally, antibacterial efficacy was developed for Gam positive and negative microorganisms. Moreover, we examined in vivo healing of skin wounds formed in mouse models over 24 days. In contrast to the untreated wounds, rapid healing was perceived in the Ce-nGel-Glu-treated wound with less damage. These findings indicate that Ce-nGel-Glu-based bandaging materials could be a potential candidate for wound healing applications in the future.

show abstract

Section: Introductionmentioning

confidence: 99%

RETRACTED ARTICLE: Cerium oxide nanoparticle-loaded polyvinyl alcohol nanogels delivery for wound healing care systems on surgery

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Guo et al constructed PEG based thermo-responsive hydrogels that can automatically change shape under 37°C rapidly without external stimulation ( Zhao et al, 2020d ). Injection or in situ formation of hydrogel ( Gao et al, 2020 ) is a good technique to achieve complete coverage over wound bed. Before injection, it is a prepolymer solution or shear-thinning hydrogel.…”

Section: Ideal Properties Of Hydrogels To Promote Wound Healingmentioning

confidence: 99%

Biomimetic Hydrogels to Promote Wound Healing

Fan

Saha

Hanjaya‐Putra

2021

Front. Bioeng. Biotechnol.

103

View full text Add to dashboard Cite

Wound healing is a common physiological process which consists of a sequence of molecular and cellular events that occur following the onset of a tissue lesion in order to reconstitute barrier between body and external environment. The inherent properties of hydrogels allow the damaged tissue to heal by supporting a hydrated environment which has long been explored in wound management to aid in autolytic debridement. However, chronic non-healing wounds require added therapeutic features that can be achieved by incorporation of biomolecules and supporting cells to promote faster and better healing outcomes. In recent decades, numerous hydrogels have been developed and modified to match the time scale for distinct stages of wound healing. This review will discuss the effects of various types of hydrogels on wound pathophysiology, as well as the ideal characteristics of hydrogels for wound healing, crosslinking mechanism, fabrication techniques and design considerations of hydrogel engineering. Finally, several challenges related to adopting hydrogels to promote wound healing and future perspectives are discussed.

show abstract

“…High-molecular polymers, e.g., poly (methacrylates) and polyvinyl pyrrolidine, are artificial polymers that are widely used, while polysaccharides (e.g., chitosan, hyaluronic acid, alginate and cellulose) and proteins (e.g., collagen, alginate and gelatin) are common natural hydrogels [ 12 ]. Hydrogels have been used for translational medicine and sealants with the advantages of better tissue adhesive character [ 19 , 27 ], rapid gelation and injectable properties [ 28 , 29 ] as well as good biocompatibility [ 30 ]. EGCG was conjugated with hyaluronic acids, and the conjugates further reacted with tyramine-conjugated hyaluronic acids through tyrosinase to form a crosslinked adhesive hydrogel [ 20 ].…”

Section: The Application Forms Of Egcg To Wound Healingmentioning

confidence: 99%

Beneficial Effects of Green Tea EGCG on Skin Wound Healing: A Comprehensive Review

Zhong

et al. 2021

Molecules

View full text Add to dashboard Cite

Epigallocatechin gallate (EGCG) is associated with various health benefits. In this review, we searched current work about the effects of EGCG and its wound dressings on skin for wound healing. Hydrogels, nanoparticles, micro/nanofiber networks and microneedles are the major types of EGCG-containing wound dressings. The beneficial effects of EGCG and its wound dressings at different stages of skin wound healing (hemostasis, inflammation, proliferation and tissue remodeling) were summarized based on the underlying mechanisms of antioxidant, anti-inflammatory, antimicrobial, angiogenesis and antifibrotic properties. This review expatiates on the rationale of using EGCG to promote skin wound healing and prevent scar formation, which provides a future clinical application direction of EGCG.

show abstract

In situ formation of injectable hydrogels for chronic wound healing

Abstract: Hydrogels have been widely used in wound healing treatment over the past decade. Injectable hydrogels have become a major research focus due to their unique advantages. Compared to traditional hydrogels,...

Cited by 122 publications

References 100 publications

RETRACTED ARTICLE: Cerium oxide nanoparticle-loaded polyvinyl alcohol nanogels delivery for wound healing care systems on surgery

RETRACTED ARTICLE: Cerium oxide nanoparticle-loaded polyvinyl alcohol nanogels delivery for wound healing care systems on surgery

Biomimetic Hydrogels to Promote Wound Healing

Beneficial Effects of Green Tea EGCG on Skin Wound Healing: A Comprehensive Review

Contact Info

Product

Resources

About