Biomimetic Hydrogels to Promote Wound Healing

Fan, Fei; Saha, Sanjoy Kumar; Hanjaya‐Putra, Donny

doi:10.3389/fbioe.2021.718377

Cited by 103 publications

(76 citation statements)

References 242 publications

(377 reference statements)

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“…The ECM mainly consisted of various collagens, polysaccharides, growth factors, and bioactive molecules. [ 75 ] The fibrous network structure and active substances of ECM can promote cell migration, proliferation, and differentiation. Biomimetic polymer hydrogels not only simulate the structure and composition of ECM, but also simulate the biochemical activity.…”

Section: Hydrogels For Wound Healingmentioning

confidence: 99%

Progress in Hydrogels for Skin Wound Repair

Zhang

Wang

et al. 2022

Macromolecular Bioscience

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As the first defensive line between the human body and the outside world, the skin is vulnerable to damage from the external environment. Skin wounds can be divided into acute wounds (mechanical injuries, chemical injuries, and surgical wounds, etc.) and chronic wounds (burns, infections, diabetes, etc.). In order to manage skin wound, a variety of wound dressings have been developed, including gauze, films, foams, nanofibers, hydrocolloids, and hydrogels. Recently, hydrogels have received much attention because of their natural extracellular matrix (ECM)‐mimik structure, tunable mechanical properties, and facile bioactive substance delivery capability. They show great potential application in skin wound repair. This paper first introduces the anatomy and function of the skin, the process of wound healing and conventional wound dressings, and then introduces the composition and construction methods of hydrogels. Next, this paper introduces the necessary properties of hydrogels in skin wound repair and the latest research progress of hydrogel dressings for skin wound repair. Finally, the future development goals of hydrogel materials in the field of wound healing are proposed.

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Section: Hydrogels For Wound Healingmentioning

confidence: 99%

Progress in Hydrogels for Skin Wound Repair

Zhang

Wang

et al. 2022

Macromolecular Bioscience

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“…To this aim, strategies including antibacterial ointments, synthetic growth factors, polyurethanes, polymeric hydrogels, and fiber dressings have been developed over the years [ 5 , 6 , 7 , 8 ]. Polymeric hydrogels showed the advantage of supporting a hydrated environment, adsorbing excess fluids [ 9 , 10 , 11 ]. Among them, those based on polysaccharides demonstrated non-toxic, biodegradable, and biocompatible properties, providing a good ability to improve the re-epithelization and acceleration of wound closure [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Biocompatible Chitosan-Based Hydrogels for Bioabsorbable Wound Dressings

Lungu

Paun

Peptanariu

et al. 2022

Gels

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Supramolecular hydrogels based on chitosan and monoaldehydes are biomaterials with high potential for a multitude of bioapplications. This is due to the proper choice of the monoaldehyde that can tune the hydrogel properties for specific practices. In this conceptual framework, the present paper deals with the investigation of a hydrogel as bioabsorbable wound dressing. To this aim, chitosan was cross-linked with 2-formylphenylboronic acid to yield a hydrogel with antimicrobial activity. FTIR, NMR, and POM procedures have characterized the hydrogel from a structural and supramolecular point of view. At the same time, its biocompatibility and antimicrobial properties were also determined in vitro. Furthermore, in order to assess the bioabsorbable character, its biodegradation was investigated in vitro in the presence of lysosome in media of different pH, mimicking the wound exudate at different stages of healing. The biodegradation was monitored by gravimetrical measurements, SEM microscopy and fractal analyses of the images. The fractal dimension values and the lacunarity of SEM pictures were accurately calculated. All these successful investigations led to the conclusion that the tested materials are at the expected high standards.

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“…Therefore, advanced dressings have been exploited such as hydrogels, thin films (membranes), nanofibers, foams, and sponges to overcome the shortcomings of conventional dressings (Y. Chen et al, 2020 ) ( Fan et al, 2021 ), providing not only a physical barrier against secondary infection, but also a compatible physiological environment. Among all these advanced dressings, hydrogel becomes a rising star in rapid wound healing ( Jacob et al, 2021 ), by providing a biocompatible, moisture, and antibacterial interface between the dressing and the wound ( Zhang et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Polysaccharide-Based Hydrogels for Wound Dressing: Design Considerations and Clinical Applications

Cui

Zhang

et al. 2022

Front. Bioeng. Biotechnol.

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Wound management remains a worldwide challenge. It is undeniable that patients with problems such as difficulties in wound healing, metabolic disorder of the wound microenvironment and even severely infected wounds etc. always suffer great pain that affected their quality of lives. The selection of appropriate wound dressings is vital for the healing process. With the advances of technology, hydrogels dressings have been showing great potentials for the treatment of both acute wounds (e.g., burn injuries, hemorrhage, rupturing of internal organs/aorta) and chronic wounds such as diabetic foot and pressure ulcer. Particularly, in the past decade, polysaccharide-based hydrogels which are made up with abundant and reproducible natural materials that are biocompatible and biodegradable present unique features and huge flexibilities for modifications as wound dressings and are widely applicable in clinical practices. They share not only common characteristics of hydrogels such as excellent tissue adhesion, swelling, water absorption, etc., but also other properties (e.g., anti-inflammatory, bactericidal and immune regulation), to accelerate wound re-epithelialization, mimic skin structure and induce skin regeneration. Herein, in this review, we highlighted the importance of tailoring the physicochemical performance and biological functions of polysaccharide-based hydrogel wound dressings. We also summarized and discussed their clinical states of, aiming to provide valuable hints and references for the future development of more intelligent and multifunctional wound dressings of polysaccharide hydrogels.

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Biomimetic Hydrogels to Promote Wound Healing

Cited by 103 publications

References 242 publications

Progress in Hydrogels for Skin Wound Repair

Progress in Hydrogels for Skin Wound Repair

Biocompatible Chitosan-Based Hydrogels for Bioabsorbable Wound Dressings

Polysaccharide-Based Hydrogels for Wound Dressing: Design Considerations and Clinical Applications

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