HLA‐A, B Haplotype Frequencies in 5,202 Unrelated Danes by a Maximum‐Likelihood Method of Gene Counting

Abstract

A population sample of 5,202 persons comprising normal, healthy individuals from three laboratories in Copenhagen was used for estimating HLA-A, -B antigen, gene, and haplotype frequencies, besides delta-values and their standard errors. The serum panels used allowed the determination of a total of 273 HLA-A, --B haplotypes, and the most significant A-values were in agreement with those found in other Caucasian populations. The methods used for the calculations of frequencies, delta-values, and standard errors are described.

The occurrence of psoriatic arthritis in Denmark

“…HLA-B27 and B13 antigen was present in 10% of the PsA cases. The prevalence of HLA-B27 and B13 antigens among Danish people has previously been reported at 9.1% and 4.2% respectively 35. None of the PsA probands had HLA-B17, HLA-B37, HLA-B39 or HLA-B62, and only one twin had HLA-B38, although all these different HLA-B types have been associated with PsA in previous studies 36 – 40…”

HLA‐A,B,C gene and haplotype frequencies in the Finnish population

“…Among the first settlers, primary gene en-richments and losses evolved and the breeding units have been small up to the present time. The Finnish HLA haplotype distributions have common Caucasoid features (Hansen et al 1979, Mayr 1977) but they also have some unique features, as has been shown in the preliminary report by Tiilikainen et al (1972). The present report is based on 1100 haplotypes from 550 genotyped persons from the whole of Finland by the direct gene counting method.…”

“…The significance of the delta values after correction for the number of comparisons made are given only for those haplotypes showing the significance at the level p < 0.01 and p < 0.001. The haplotypes with positive linkage disequilibrium value are given in Table 3 and with negative delta value in Among the Finnish HLA-A,B haplotypes with significant positive delta value there are many common haplotypes found in Caucasian populations, for example HLA-A1 ;B8, A3;B7, A2;B15, Al;B17, A3;Bw35, Aw24; Bw39, A25;B18, A26;Bw38, Aw33;B14 (Degos et al 1974, Mayr 1977, Hansen et al 1979, Pickbourne et al 1977), but we have HLA-A,B and B,C Al;B15, A1 ;Bw35), but every haplotype with significant negative value in Danes is not significant among the Finnish population (Aw30/w31;Bw44, Aw30Iw31 ;B8, A29;B7, A11;B8, A3;B17, A3;Bw44, A2;B14, A1;BlS). The haplotypes HLA-A1;B14, A2;B13, A2;Bw22, A3;Bw41, Aw24;B40, A26;B40, A26;Bw44, A28;B8, A28;Bw38, A29;B40, A29;Bw41, Aw31;Bw22 have most prominent differences between Danes and Finns having negative delta values in Danes and positive in Finns, especially the haplotype HLA-A28;B8 (in Finns x2 = 12.89).…”

“…The expected frequency is the product of the appropriate pair of allele frequencies. The statistical significance of the linkage dis- (Hansen et al 1979, Mayr 1977, Staub Nielsen et al 1975a). HLA-A,B and B,C haplotype frequencies X 104and delta value,?…”