HLA‐A,B,C gene and haplotype frequencies in the Finnish population

Lokki, Marja-Liisa; Julin, Marja

doi:10.1111/j.1399-0039.1982.tb00352.x

Tissue Antigens

1982

DOI: 10.1111/j.1399-0039.1982.tb00352.x

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HLA‐A,B,C gene and haplotype frequencies in the Finnish population

Marja-Liisa Lokki

Marja Julin

Abstract: The HLA‐A,B,C gene and haplotype frequencies calculated by the direct gene counting method from the genotypes of 550 unrelated Finns are reported. The typings were done during the years 1978‐1980. The delta values are given for the HLA‐A,B and B,C haplotypes. Some comparisons between Finns and other European populations are stated.

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Cited by 11 publications

References 15 publications

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A comparative study of HLA genes in HLA–B27 positive ankylosing spondylitis and HLA–B27 positive peripheral reactive arthritis

Westman

Leirisalo‐Repo

Partanen

et al. 1996

Arthritis & Rheumatism

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Objective. To determine whether HLA-B27 positive patients with ankylosing spondylitis (AS) and reactive arthritis (ReA) share additional HLA factors that confer disease susceptibility.Methods. HLA class I antigens were typed serologically, and class I1 antigens molecularly, in samples taken from 33 patients with AS, 30 patients with ReA, and 55 healthy HLA-B27 positive controls.Results. There was no major difference between the HLA alleles in AS and ReA patients, but deviations were observed when compared with healthy controls, especially between the antigens that were probably encoded by genes in the non-B27 chromosome.Conclusion. These results suggest that both HLA class I and class I1 genes may influence the pathogenesis of HLA-B27 positive ReA, whereas class I antigens seem to be the major additional genetic factors in HLA-B27 positive AS.Reactive arthritis (ReA) is a seronegative spondylarthropathy in which a genetically directed response to environmental factors triggers the disease. In ReA, the pathogenic environmental factors are certain types of bacteria, but in ankylosing spondylitis (AS), which is the prototype and most severe form of seronegative spondylarthropathy, the pathogenic factors remain unidentified despite intensive research (1-4).The relationship between AS and ReA is complex. Although AS has been suggested to be an endpoint

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A comparative study of HLA genes in HLA–B27 positive ankylosing spondylitis and HLA–B27 positive peripheral reactive arthritis

Westman

Leirisalo‐Repo

Partanen

et al. 1996

Arthritis & Rheumatism

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A ?new? DR4 associated D specificity ?JA? in Type 1 (insulin-dependent) diabetes: A9, Bw16, DJA, DR4 haplotype

et al. 1984

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The HLA antigen combination A9, Bw16 has been found to be associated with Type 1 (insulin-dependent) diabetes characterized by some special features in Northern Finland. This antigen combination has now been associated with a 'new' DR4-associated D antigen, provisionally called 'JA' or 'SN'. This 'new' D specificity was also associated with HLA-B18. Although the combination, Dw3/DJA, was common in Type 1 diabetic patients, the frequency of the combination Dw4/DJA was decreased compared with the expected value. This supports the hypothesis of two different risk factors associated with DR3 and DR4.

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Genetic susceptibility to severe course of nephropathia epidemica caused by Puumala hantavirus

Mustonen

Partanen

Kanerva

et al. 1996

Kidney International

172

110

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Nephropathia epidemica (NE) caused by Puumala hantavirus is one type of hemorrhagic fever with renal syndrome (HFRS). There is considerable variability in the clinical severity of NE. Many infections are subclinical but the disease can even be fatal. We questioned whether the wide spectrum in the outcome of NE is dependent, on host-related immunological factors by determining the major histocompatibility complex markers (MHC) in 74 adult patients with NE. Patients with the most severe course of the disease had a very high frequency of HLA B8, C4A*Q0, and DRB1*0301 alleles. HLA B8 was found in all 7 (100%) patients with shock and in 9 of the 13 (69%) patients who required dialysis, versus in only 25 of 74 (34%) in the entire population, and in 14 of 93 (15%) controls. In addition, various other clinical findings pointing to a severe form of NE were found to be associated with these alleles. Interestingly, the same MHC alleles are risk factors for various autoimmune diseases. This is the first study where a certain HLA haplotype is found to be associated with the clinical course of an acute viral disease or acute nephritis.

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HLA‐A,B,C gene and haplotype frequencies in the Finnish population

Cited by 11 publications

References 15 publications

A comparative study of HLA genes in HLA–B27 positive ankylosing spondylitis and HLA–B27 positive peripheral reactive arthritis

A comparative study of HLA genes in HLA–B27 positive ankylosing spondylitis and HLA–B27 positive peripheral reactive arthritis

A ?new? DR4 associated D specificity ?JA? in Type 1 (insulin-dependent) diabetes: A9, Bw16, DJA, DR4 haplotype

Genetic susceptibility to severe course of nephropathia epidemica caused by Puumala hantavirus

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