Haemophilus paraphrophilusEndocarditis in a Prolapsed Mitral Valve

Infective Endocarditis and Other Intravascular Infections

“…(173.174) The ability to tolerate the absence of the tricuspid valve for varying lengths of time has led some surgeons to propose a two-stage procedure in cases where tricuspid-valve surgery is necessary: first, to remove infected valve tissue serving as the source of pulmonary emboli; second, at a later time, to insert a prosthetic valve in an operative field which has been properly sterilized with antibiotics. (175)(176)(177) Destruction of the mitral valve has important hemodynamic consequences, but these may be difficult to distinguish from those of simultaneously occurring lesions of the aortic valve. Mitral-valve destruction alone appears to be relatively well tolerated,(5) whereas severe CHF with a fatal outcome is frequently seen when both aortic and mitral valves are involved.…”

“…In four instances, Hemophilus infection has occurred in patients with prolapsed mitral valves and in one instance in a patient with a "floppy" valve of Marfan's syndrome. (166,173,174,175) There is an uncommonly long delay in establishing the diagnosis, with periods of 4-6 months of symptoms being characteristic. Cardiobacterium hominis infections are outstanding in this regard, with patients having symptoms lasting 10 and 18 months prior to diagnosis.…”

Haemophilus paraphrophilus, a rare cause of intracerebral abscess in children

“…paraphrophilus, first described in 1968, is a pathogen that is recognised as a very rare cause of intracranial abscesses [3]. Misidentification has been reported due to its ability to cause pitting in agar, which is commonly associated with E. corrodens and due to its morphological similarity to H. parainfluenzae and H. aphrophilus [1,2]. Thirty-four strains of H. paraphrophilus were identified at the NCTC (National Collection of Type Cultures) in a 10-year period [1].…”

Infective Endocarditis by Aggregatibacter paraphrophilus : Case Report and Literature Review

“…The first case of H.paraphrophilus endocarditis was reported by De Silva et al, [10]. As has been described for other Haemophilus species, it is possible that H.paraphrophilus causes some of the cases of endocarditis in which blood cultures are persistently negative, thereby explaining the small number of clinical reports of infections caused by this organism [11].…”