Haemophilus paraphrophilus, a rare cause of intracerebral abscess in children

Hoefele, Julia; Kroener, Carolin; Berweck, Steffen; Peraud, Aurelia; Grabein, B.; Wintergerst, Uwe; Liese, Johannes G.

doi:10.1007/s00431-007-0560-6

Cited by 7 publications

(4 citation statements)

References 12 publications

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“…Phenotypic characteristics differentiating A. paraphrophilus from other HACEK group species are shown in Table 1. Fortunately, A. paraphrophilus is sensitive to a wide range of antibiotics [8]. Production of beta-lactamase should be tested, while third-generation cephalosporins should be considered drug of choice [9].…”

Section: Discussionmentioning

confidence: 99%

Haemophilus paraphrophilus brain abscess in a 9-year-old boy: Case report and literature review

Zrikem

Said

Zahlane

2020

IJAB

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Human diseases due to A. paraphrophilus aren’t usual. The following case report describes the first isolated case of A. paraphrophilus brain abscess in our laboratory. A 9-year-old boy presented to pediatric emergencies for frontal headache, vomiting, blurred vision and left hemiparesis. Radiological diagnosis consists with a frontal abscess. Gram staining of purulent samples showed abundant neutrophils with gram negative bacilli. Culture was made on blood agar, chocolate agar, Chapman’s agar and incubated in 5% CO2 at 37°C for 24 hours. Positive culture was detected only on chocolate agar. It was monomicrobial with small yellowish non-hemolytic colonies. Gram stain of colonies showed pleomorphic gram-negative coccobacilli. The strain required V factor for growth. The isolated strain was sensitive to all antibiotics tested. The interest of this case is that it shows the emergence of A. paraphrophilus as a causative agent of brain abscesses on pediatric population without associated congenital heart disease. It may also help identifying risk factors of these infections and how to prevent them.

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Section: Discussionmentioning

confidence: 99%

Haemophilus paraphrophilus brain abscess in a 9-year-old boy: Case report and literature review

Zrikem

Said

Zahlane

2020

IJAB

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“…The total treatment duration with a third-generation cephalosporin is 6 weeks. Other cases of H paraphrophilus abscesses have been successfully treated with surgical drainage plus antibiotic therapy using combinations of cefotaxime, ciprofloxacin, meropenem, metronidazole, ceftriaxone, amoxicillin/clavulanic acid, gentamicin, flucloxacillin, piperacillin, ampicillin and penicillin G 20 21…”

Section: Discussionmentioning

confidence: 99%

HACEK-induced endocarditis

Wassef¹,

Rizkalla

Shaukat

et al. 2013

BMJ Case Reports

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A 61-year-old patient with diabetes had a bio-prosthetic aortic valve replacement 3 years before admission. He complained of lethargy, night sweats, decreased appetite and erratic blood glucose with no weight loss. He had splinter haemorrhage and a systolic ejection murmur at the aortic area. Chest and abdominal examination revealed no abnormality. The erythrocyte sedimentation rate and C reactive protein were raised. He had several sets of blood cultures and he was started on empirical vancomycin, rifampicin and gentamicin. Transthoracic echocardiography showed vegetation on the base of the anterior mitral leaflet, which was confirmed by a trans-oesophageal echocardiography. Blood culture was positive for Haemophilus aphrophilus, and he was started on ceftriaxone for 6 weeks instead of vancomycin and rifampicin and continued gentamicin for 2 weeks. Follow-up echocardiography showed no evidence of vegetations. The patient recovered completely and he was discharged home.

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“…This organism has been implicated in causing cerebral abscesses, meningitis, subacute endocarditis, larynogo-epiglottitis, pneumonitis, hepatobiliary infections, endophthalmitis, peritonitis, parotid gland abscess, osteomyelitis and septic arthritis in adults [7,8]. Clinical infection caused by H.paraphrophilus is the result of local or blood stream invasion from the site of colonization [9].…”

Section: Referencesmentioning

confidence: 99%

Infective Endocarditis by Aggregatibacter paraphrophilus : Case Report and Literature Review

Sood¹

2013

JCDR

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DISCUSSIONThe first description of Hemophilus paraphrophilus was given by Zinneman et al. It was described as a fastidious, catalase-negative, oxidase -positive, V-factor dependant, gram negative cocco-bacillus that needed a carbon dioxide enriched atmosphere for supporting its growth [4]. A recent reclassification has placed these organisms in a new genus of Aggregatibacter, as they are independent of factor X and variably dependent on factor V for their growth in vitro [5].This organism is a normal commensal inhabiting the oro-pharynx, nasopharynx and lower gastrointestinal tract [6]. Human diseases microbiology Section ABSTRACTAggregatibacter paraphrophilus (former name, Haemophilus paraphrophilus) is a normal inhabitant of the naso-and oropharynx and has been rarely reported as a cause of human infections. A case of infective endocarditis by this organism is being reported and literature of endocarditis cases caused by Aggregatibacter paraphrophilus is being reviewed.

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Haemophilus paraphrophilus, a rare cause of intracerebral abscess in children

Abstract: We report on a 3-year-old boy presenting with left-sided eyelid myocloni due to an intracranial abscess harboring Haemophilus paraphrophilus. This is the first description of an intracranial infection with this pathogen in a child.

Cited by 7 publications

References 12 publications

Haemophilus paraphrophilus brain abscess in a 9-year-old boy: Case report and literature review

Haemophilus paraphrophilus brain abscess in a 9-year-old boy: Case report and literature review

HACEK-induced endocarditis

Infective Endocarditis by Aggregatibacter paraphrophilus : Case Report and Literature Review

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