<i>fosI</i>
            Is a New Integron-Associated Gene Cassette Encoding Reduced Susceptibility to Fosfomycin

Pelegrino, Karla de Oliveira; Campos, Juliana Coutinho; Sampaio, Suely Carlos Ferreira; Lezirovitz, Karina; Seco, Bruna Mara Silva; Pereira, Mayne de Oliveira; Rocha, Darlan Augusto da Costa; Jové, Thomas; Nicodemo, Antônio Carlos; Sampaio, Julliane Messias Cordeiro

doi:10.1128/aac.02437-15

Cited by 3 publications

(1 citation statement)

References 22 publications

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“…The first, FosA, which encodes (Mn⁺²)-dependent glutathione-S-transferase (GST). FosA and its subtypes, and FosC2 were mainly responsible for fosfomycin resistance in Enterobacteriaceae 10 . The FosA3 in plasmids has been the most frequently found FosA subtype.…”

Section: Introductionmentioning

confidence: 99%

Activity of Fosfomycin against Extended-Spectrum-Beta-Lactamase producing Enterobacteriaceae isolates from Menoufia University Hospitals

Ghonaim

Makled

Sharweed

2020

Egyptian Journal of Medical Microbiology

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Background: Fosfomycin is an old antibiotic that is being reconsidered for the treatment of lower urinary tract, due to the global increasing resistance of several bacteria to numerous-antimicrobials. Objectives: To evaluate the activity of fosfomycin and to detect fosfomycin resistant genes (FosA3 and FosC2) in extended-spectrum-beta-lactamase producing Enterobacteriaceae isolates from Menoufia University Hospitals. Methodology: The study included 155 samples collected from patients from different departments and ICUs at Menoufia University Hospitals, detected the ESBLproducing,by combined confirmatory method, fosfomycin resistance was assessed by disk diffusion and the minimal inhibitory concentration (MIC) by E-test method and fosfomycin resistance genes (FosA3 and FosC2) were detected by the conventional PCR. Results: Among the 48 ESBL-producing Enterobacteriaceae isolates analyzed in this study, 21 isolates had fosfomycin resistant genes (FosA3 and FosC2). Conclusion: Fosfomycin showed good antimicrobial activity against multidrug-resistant ESBLpositive Enterobacteriaceae. Resistance genes (FosA3 and FosC2) were detected in some strains, however, other resistance mechanisms to fosfomycin may exist.

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Section: Introductionmentioning

confidence: 99%

Activity of Fosfomycin against Extended-Spectrum-Beta-Lactamase producing Enterobacteriaceae isolates from Menoufia University Hospitals

Ghonaim

Makled

Sharweed

2020

Egyptian Journal of Medical Microbiology

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Epidemiology of Bacterial Resistance

Bradford¹

2018

Antimicrobial Resistance in the 21st Century

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Update on fosfomycin-modified genes in Enterobacteriaceae

Yang

Tseng

2019

Journal of Microbiology, Immunology and Infection

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The long-used antibiotic fosfomycin has recently been re-evaluated as a potential regimen for treating extended-spectrum β-lactamases (ESBLs) and carbapenem-resistant Enterobacteriaceae (CRE). Fosfomycin is known for its robust bactericidal effect against ESBL-producing Enterobacteriaceae and CRE. However, fosfomycin-modified genes have been reported in transposon elements and conjugative plasmids, resulting in fosfomycin resistance in parts of East Asia. Here we review reports of fosfomycin-modified (fos) genes in Enterobacteriaceae and assess the efficacy of fosfomycin against multidrug-resistant Enterobacteriaceae infections. At least 10 kinds of fos genes have been identified in the past decade; of these, fosA (and fosA subtypes) and fosC2 are primarily found in Enterobacteriaceae. All fosA subtypes except fosA2 are found in plasmids and transposons, nearby insertion sequence elements, or integrons, indicating that mobilizing elements also play an important role in plasmid-mediated fos genes in Enterobacteriaceae. fosA3, which is prevalent in East Asia, has been transmitted (mostly by animals) within and across continents via IS26 mobile elements. The acquisition of multiple antibiotic resistance genes via plasmids and mobile elements has resulted in a need for combined treatments for Enterobacteriaceae cases. The combination of fosfomycin and carbapenem has been the focus of many in vitro studies, but there is a clear need for additional in vivo investigations involving pharmacokinetics.

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fosI Is a New Integron-Associated Gene Cassette Encoding Reduced Susceptibility to Fosfomycin

Cited by 3 publications

References 22 publications

Activity of Fosfomycin against Extended-Spectrum-Beta-Lactamase producing Enterobacteriaceae isolates from Menoufia University Hospitals

Activity of Fosfomycin against Extended-Spectrum-Beta-Lactamase producing Enterobacteriaceae isolates from Menoufia University Hospitals

Epidemiology of Bacterial Resistance

Update on fosfomycin-modified genes in Enterobacteriaceae

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