Escherichia coliNissle 1917 Distinctively Modulates T-Cell Cycling and Expansion via Toll-Like Receptor 2 Signaling

The K5 Capsule of Escherichia coli Strain Nissle 1917 Is Important in Stimulating Expression of Toll-Like Receptor 5, CD14, MyD88, and TRIF Together with the Induction of Interleukin-8 Expression via the Mitogen-Activated Protein Kinase Pathway in Epithelial Cells

“…In addition, it has been shown that probiotic lactobacilli upregulate TLR2 expression (54,55). The observation that Nissle 1917 increased TLR4 and TLR5 expression may in part explain the ability of Nissle 1917 to induce a chemokine response following exposure to the basolateral surfaces of polarized epithelial cells (19) and the finding that Nissle 1917 ameliorates experimental colitis via activation of the TLR4 and TLR2 signaling pathways (14,47). The increase in signaling will also lead to induction of antimicrobial peptides that are induced following treatment with Nissle 1917 and will help to combat pathogenic bacteria (44).…”

Induction of Human β-Defensin 2 by the ProbioticEscherichia coliNissle 1917 Is Mediated through Flagellin

“…Recent in vitro data have demonstrated that E. coli Nissle 1917 induces intestinal epithelial cells to block adherence and inhibit invasion of various pathogenic strains (1,5). These observations proposed a soluble factor responsible for the inhibition of the pathogen itself or engagement of an epithelial defense mechanism (1) apart from anti-inflammatory influences on T-cell proliferation and function (38). We have recently provided a possible explanation for the probiotic effect of E. coli Nissle 1917 as it induces human ␤-defensin 2 (hBD-2) expression in cell culture in a time-and dose-dependent manner (41).…”

Commensal Microorganisms in Development of the Children Immune System and New Facilities of Probiotics Usage

“…В конце периода наблюдения в группе, получавшей Bifidobacterium lactis BВ12, индекс SCORAD [первоначально равный 16 (7-25)] составил 0 (0-3,8), тогда как в группе, получавшей Lactobacillus GG, эта вели-чина равнялась 1 (0,1-8,7). Среди детей, получавших смесь без введения пробиотиков, индекс SCORAD соста-вил 13,4 (4,(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)2). Таким образом, в данном исследо-вании показана не только эффективность пробиотиков для профилактики аллергии, но и более выраженное действие штамма Bifidobacterium lactis BВ12.…”