2020
DOI: 10.1002/iid3.284
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Abstract: Introduction Corynebacterium tuberculostearicum (C. t.) is a ubiquitous bacterium that colonizes human skin. In contrast to other members of the genus Corynebacterium, such as toxigenic Corynebacterium diphtheriae or the opportunistic pathogen Corynebacterium jeikeium, several studies suggest that C. t. may play a role in skin health and disease. However, the mechanisms underlying these effects remain poorly understood. Methods To investigate whether C. t. induces inflammatory pathways in primary human epiderm… Show more

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Cited by 23 publications
(28 citation statements)
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“…Similar data were previously collected for viability assays performed with Esc(1-21) at the same concentrations, except for the greater cytotoxicity against macrophages at 64 µM (i.e., about 50% cell viability) [41]. Lacking the harmful effect of esculentin peptides, particularly for Esc (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18) at the antimicrobial concentrations (MIC and MBC values), suggested they are safe compounds, also for long-term treatment.…”
Section: Peptides' Effect On the Metabolic Activity Of Mammalian Cellssupporting
confidence: 71%
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“…Similar data were previously collected for viability assays performed with Esc(1-21) at the same concentrations, except for the greater cytotoxicity against macrophages at 64 µM (i.e., about 50% cell viability) [41]. Lacking the harmful effect of esculentin peptides, particularly for Esc (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18) at the antimicrobial concentrations (MIC and MBC values), suggested they are safe compounds, also for long-term treatment.…”
Section: Peptides' Effect On the Metabolic Activity Of Mammalian Cellssupporting
confidence: 71%
“…However, no studies have been conducted so far for these peptides, as well as for other AMPs, against C. jeikeium. Here, for the first time, we analyzed the effect of some frog skin AMPs against this bacterium and selected the esculentin peptides as the most active molecules with an MIC of 0.125 and 4 µM for Esc and Esc (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18), respectively. This outcome is in sharp contrast with the weaker activity of Esc(1-21) previously recorded against other Gram-positive bacteria (e.g., Staphylococcus aureus, S. epidermidis), where MICs ranging from 1 to 64 µM were found [37].…”
Section: Discussionmentioning
confidence: 99%
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