Cutaneous T-Cell Lymphoma Skin Microbiome Is Characterized by Shifts in Certain Commensal Bacteria but not Viruses when Compared with Healthy Controls

Harkins, Catriona P.; MacGibeny, Margaret A.; Thompson, Katherine G.; Bubic, Bianka N.; Huang, Xin; Brown, Isabelle; Park, Jin; Jo, Jay‐Hyun; Segre, Julia A.; Kong, Heidi H.; Rozati, Sima

doi:10.1016/j.jid.2020.10.021

Cited by 24 publications

(31 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, other related Bacillus species, B. thuringiensis and B. licheniformis, that we cultured from lesions of patients MF03 and MF06 in our study ( Fig. 2E), were also present in another recent CTCL skin microbiome study from the US (Harkins et al, 2021). Importantly, functional analyses of T cell proliferation and cytokine secretion support a mechanistic role for B. safensis in the pathogenesis of MF.…”

Section: Cutaneous T Cells Proliferate In Response To Bacterial Antigensupporting

confidence: 73%

Malignant T Cell Activation by a Bacillus Species Isolated from Cutaneous T-Cell Lymphoma Lesions

et al. 2022

View full text Add to dashboard Cite

This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

show abstract

Section: Cutaneous T Cells Proliferate In Response To Bacterial Antigensupporting

confidence: 73%

Malignant T Cell Activation by a Bacillus Species Isolated from Cutaneous T-Cell Lymphoma Lesions

et al. 2022

View full text Add to dashboard Cite

show abstract

“…However, statistical significance was not reached, likely due to the small sample number [20]. C. tuberculosearicum can upregulate and/or induce inflammatory responses in keratinocyte derived cell lines in vitro and may contribute to cutaneous malignancies [94].…”

Section: Microbiome On Ctcl Lesionsmentioning

confidence: 97%

“…Staphylococci increase during AD flare, whereas relative abundances of other microbial genera vary across AD disease states, pointing to the complex relationship present in microbial communities [91,92]. On the other hand, Harkins et al [20] found no differences in the microbial diversity investigating early and advanced stage MF and SS patients compared to age-, sex-and sampling site-matched healthy volunteers. Fungal and viral abundances were low and showed no differences to healthy volunteers, contradicting hints about viral implications in CTCL [93].…”

Section: Microbiome On Ctcl Lesionsmentioning

confidence: 98%

“…Indeed, CTCL exhibits an impaired skin barrier and deficient expression of several AMPs leads to increased susceptibility for skin infections and bacterial toxins may play a major role in driving disease progression [55,59,67,68]. Since microbial colonization is not consistent between CTCL patients, as shown in an early study by Axelrod et al [14] and extended by two investigations utilizing microbiomics [20,21], differential microbial colonization may account for transcriptional heterogeneity.…”

Section: Single Cell Transcriptome Signatures Suggest Microbial Influ...mentioning

confidence: 99%

“…In general, several microbiota or a dysfunctional microbial community can influence cancers and other skin diseases [18,19]. Regarding CTCL, the complex microbiome patterns possibly influencing the course of this disease have only recently begun to be investigated [20,21]. Genomic methods to study microbiota can provide deep insights into shifted microbial communities relating disease [19].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Transcriptional Heterogeneity and the Microbiome of Cutaneous T-Cell Lymphoma

Licht

Mailänder

2022

Cells

View full text Add to dashboard Cite

Cutaneous T-Cell Lymphomas (CTCL) presents with substantial clinical variability and transcriptional heterogeneity. In the recent years, several studies paved the way to elucidate aetiology and pathogenesis of CTCL using sequencing methods. Several T-cell subtypes were suggested as the source of disease thereby explaining clinical and transcriptional heterogeneity of CTCL entities. Several differentially expressed pathways could explain disease progression. However, exogenous triggers in the skin microenvironment also seem to affect CTCL status. Especially Staphylococcus aureus was shown to contribute to disease progression. Only little is known about the complex microbiome patterns involved in CTCL and how microbial shifts might impact this malignancy. Nevertheless, first hints indicate that the microbiome might at least in part explain transcriptional heterogeneity and that microbial approaches could serve in diagnosis and prognosis. Shaping the microbiome could be a treatment option to maintain stable disease. Here, we review current knowledge of transcriptional heterogeneity of and microbial influences on CTCL. We discuss potential benefits of microbial applications and microbial directed therapies to aid patients with CTCL burden.

show abstract

Mycology in Oncology: Exploring the Role of the Mycobiome in Human Cancer, Etiology, Progression, Epidemiology, Mycoses, and Mycotoxins

Velez-Haro,

Pérez-Rodríguez,

Velázquez-Márquez

et al. 2024

Pathogens Associated With the Development of Cancer in Humans

View full text Add to dashboard Cite

Cutaneous T-Cell Lymphoma Skin Microbiome Is Characterized by Shifts in Certain Commensal Bacteria but not Viruses when Compared with Healthy Controls

Cited by 24 publications

References 15 publications

Malignant T Cell Activation by a Bacillus Species Isolated from Cutaneous T-Cell Lymphoma Lesions

Malignant T Cell Activation by a Bacillus Species Isolated from Cutaneous T-Cell Lymphoma Lesions

Transcriptional Heterogeneity and the Microbiome of Cutaneous T-Cell Lymphoma

Mycology in Oncology: Exploring the Role of the Mycobiome in Human Cancer, Etiology, Progression, Epidemiology, Mycoses, and Mycotoxins

Contact Info

Product

Resources

About