Copaifera oleoresins as a novel natural product against acanthocephalan in aquaculture: Insights in the mode of action and toxicity

Abstract

The production of tambaqui Colossoma macropomum has reached a milestone in South American aquaculture, being the most farmed native fish in the continent (IBGE, 2018; Valladão, Gallani, & Pilarski, 2018). The farming of tambaqui is encouraged in several tropical countries because the species presents many advantages amenable to intensive farming (e.g. domesticable, omnivorous and easily reproduced). However, parasitism caused by acanthocephalan Neoechinorhynchus buttnerae is a serious problem for tambaqui

The farming and husbandry ofColossoma macropomum: From Amazonian waters to sustainable production

“…Recent in vitro studies have reported the potential of natural plant extracts 315 organic acids, essential oils 316 and oleoresins 317 to kill the acanthocephalan, and in vivo studies have shown that a commercial phytobiotic 318 and plant essential oils 319 have reduced the burden of parasitism at different levels. Recent in vitro studies have reported the potential of natural plant extracts, 315 organic acids, essential oils 316 and oleoresins 317 to kill the acanthocephalan, and in vivo studies have shown that a commercial phytobiotic 318 and plant essential oils 319 have reduced the burden of parasitism at different levels.…”

“…Recent in vitro studies have reported the potential of natural plant extracts 315 organic acids, essential oils 316 and oleoresins 317 to kill the acanthocephalan, and in vivo studies have shown that a commercial phytobiotic 318 and plant essential oils 319 have reduced the burden of parasitism at different levels. Recent in vitro studies have reported the potential of natural plant extracts, 315 organic acids, essential oils 316 and oleoresins 317 to kill the acanthocephalan, and in vivo studies have shown that a commercial phytobiotic 318 and plant essential oils 319 have reduced the burden of parasitism at different levels. However, there is still no consensus on the effectiveness of acanthocephalosis control in farmed tambaqui based only on fish medication, mainly because it is a disease caused by infected zooplankton that are dispersed three‐dimensionally throughout the farming environment, making disease prevalence and relapse imminent if preventive measures are not in effect.…”

Acanthocephalans parasites in farmed fish in Brazil: A review

“…In addition to possessing anti‐inflammatory and healing properties, copaiba oil‐resins, especially Copaifera duckei , Copaifera pubiflora , Copaifera reticulata and Copaifera paupera , have been tested for fish farming application, at maximum concentration (0.1868 mg ml −1 ), they killed 100% of N . buttnerae (Seixas et al, 2020). Lopes et al (2020) demonstrated that piney extract of Mimosa caesalpiniifolia showed greater efficiency than Cinnamomum zeylanicum and killed 100% of N .…”

Treatments for the control of Neoechinorhynchus buttnerae (Acanthocephala) in tambaqui Colossoma macropomum

“…Very few studies have tested anthelmintic drugs to treat acanthocephalan infections (Chagas et al, 2015;Valladão et al, 2019;Farias et al, 2021). In vitro tests against N. buttnerae have been conducted with avermectins, praziquantel and levamisole (Oliveira et al, 2019), oleoresins from Copaifera (Seixas et al, 2020), and essential oils of Aloysia triphylla, Adenocalymna alliaceum, Allium sativum, Croton cajucara, Curcuma longa, Lippia gracilis, Lippia origanoides, Ocimum gratissimum, Mentha arvensis and Piper aduncum (Oliveira et al, 2021). While, in vivo tests were conducted with albendazole and praziquantel (Farias et al 2021), fenbendazole and levamisole (Sebastião et al, 2022), essential oils of Mentha piperita, Lippia alba and Zingiber o cinale (Costa et al, 2020) and a food additive, Acantex® (Sebastião et al, 2020).…”