<i>Coccidioides posadasii</i>Infection in Bats, Brazil

Cordeiro, Rossana de Aguiar; Silva, Kylvia Rocha de Castro e; Brilhante, Raimunda Sâmia Nogueira; Moura, Francisco Bergson Pinheiro; Duarte, Naylê Francelino Holanda; Marques, Francisca Jakelyne de Farias; Cordeiro, Rebecca de Aguiar; Filho, Renato Evando Moreira; Araujo, Roberto Wagner Bezerra de; Bandeira, Tereza de Jesus Pinheiro Gomes; Rocha, Marcos Fábio Gadelha; Sidrim, José Júlio Costa

doi:10.3201/eid1804.111641

Cited by 40 publications

(24 citation statements)

References 12 publications

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“…Coccidioides posadasii infection has been reported in a free-ranging Carollia perspicillata in Brazil. This bat had mature spherules with endospores in the lung but it is unclear whether this was causing clinical disease (Cordeiro et al, 2012).…”

Section: Additional Fungal Diseasesmentioning

confidence: 99%

Chiroptera

Farina

Lankton

2018

Pathology of Wildlife and Zoo Animals

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FIGURE 25.2 Normal patagium, Pteropus vampyrus. The patagium consists of two thin layers of epidermis separated by collagen, vessels, and bundles of elastic fibers. FIGURE 25.1 FIGURE 25.4 Normal brain, Pteropus hypomelanus. The brain is largely lissencephalic, with rare shallow sulci. (Photo Courtesy of E. Kieran, University of Florida) FIGURE 25.5 Iron overload in the liver, Rousettus aegyptiacus. (A) Bridging fibrosis with iron overload. Abundant brown pigment is present within and at the margins of the connective tissue. (B) Abundant hemosiderin is present in macrophages at the margins of and within the fibrous connective tissue, with lesser amounts in hepatocytes, bile ducts, and Kupffer cells. Prussian blue.

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Section: Additional Fungal Diseasesmentioning

confidence: 99%

Chiroptera

Farina

Lankton

2018

Pathology of Wildlife and Zoo Animals

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“…However, to date, zoonotic transmission to humans has not been reported. Although carcasses or excretions from infected rodents have been hypothesized to play a role in the environmental life cycle of the fungus,14,18 the extent to which rodents or other animals such as bats20 or armadillos21 act as a reservoir for Coccidioides or influence its geographic distribution is still unknown. Comparative whole genome sequencing data suggest that Coccidioides have evolved in response to interaction with an animal host 22…”

Section: Ecologymentioning

confidence: 99%

Coccidioidomycosis: epidemiology

Thompson¹,

Brown²,

Benedict³

et al. 2013

CLEP

134

106

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Coccidioidomycosis consists of a spectrum of disease, ranging from a mild, self-limited, febrile illness to severe, life-threatening infection. It is caused by the soil-dwelling fungi, Coccidioides immitis and C. posadasii, which are present in diverse endemic areas. Climate changes and environmental factors affect the Coccidioides lifecycle and influence infection rates. The incidence of coccidioidomycosis has risen substantially over the past two decades. The vast majority of Coccidioides infections occur in the endemic zones, such as California, Arizona, Mexico, and Central America. Infections occurring outside those zones appear to be increasingly common, and pose unique clinical and public health challenges. It has long been known that elderly persons, pregnant women, and members of certain ethnic groups are at risk for severe or disseminated coccidioidomycosis. In recent years, it has become evident that persons with immunodeficiency diseases, diabetics, transplant recipients, and prisoners are also particularly vulnerable.

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“…This hypothesis is supported by the recent findings by Cordeiro et al . [40] who demonstrated the infection by Coccidioides spp. in these mammals.…”

Section: Discussionmentioning

confidence: 99%

AFLP analysis reveals high genetic diversity but low population structure in Coccidioides posadasiiisolates from Mexico and Argentina

et al. 2013

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BackgroundCoccidioides immitis and C. posadasii cause coccidioidomycosis, a disease that is endemic to North and South America, but for Central America, the incidence of coccidioidomycosis has not been clearly established. Several studies suggest genetic variability in these fungi; however, little definitive information has been discovered about the variability of Coccidioides fungi in Mexico (MX) and Argentina (AR). Thus, the goals for this work were to study 32 Coccidioides spp. isolates from MX and AR, identify the species of these Coccidioides spp. isolates, analyse their phenotypic variability, examine their genetic variability and investigate the Coccidioides reproductive system and its level of genetic differentiation.MethodsCoccidioides spp. isolates from MX and AR were taxonomically identified by phylogenetic inference analysis using partial sequences of the Ag2/PRA gene and their phenotypic characteristics analysed. The genetic variability, reproductive system and level of differentiation were estimated using AFLP markers. The level of genetic variability was assessed measuring the percentage of polymorphic loci, number of effective allele, expected heterocygosity and Index of Association (IA). The degree of genetic differentiation was determined by AMOVA. Genetic similarities among isolates were estimated using Jaccard index. The UPGMA was used to contsruct the corresponding dendrogram. Finally, a network of haplotypes was built to evaluate the genealogical relationships among AFLP haplotypes.ResultsAll isolates of Coccidioides spp. from MX and AR were identified as C. posadasii. No phenotypic variability was observed among the C. posadasii isolates from MX and AR. Analyses of genetic diversity and population structure were conducted using AFLP markers. Different estimators of genetic variability indicated that the C. posadasii isolates from MX and AR had high genetic variability. Furthermore, AMOVA, dendrogram and haplotype network showed a small genetic differentiation among the C. posadasii populations analysed from MX and AR. Additionally, the IA calculated for the isolates suggested that the species has a recombinant reproductive system.ConclusionsNo phenotypic variability was observed among the C. posadasii isolates from MX and AR. The high genetic variability observed in the isolates from MX and AR and the small genetic differentiation observed among the C. posadasii isolates analysed, suggest that this species could be distributed as a single genetic population in Latin America.

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Coccidioides posadasiiInfection in Bats, Brazil

Cited by 40 publications

References 12 publications

Chiroptera

Chiroptera

Coccidioidomycosis: epidemiology

AFLP analysis reveals high genetic diversity but low population structure in Coccidioides posadasiiisolates from Mexico and Argentina

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