<i>Campylobacter rectus</i> Mediates Growth Restriction in Pregnant Mice

Yeo, Alvin; Smith, Mary Alice; Lin, Dongming; Riche, Estelle; Moore, Adam J.; Elter, John R.; Offenbacher, Steven

doi:10.1902/jop.2005.76.4.551

Cited by 45 publications

(51 citation statements)

References 24 publications

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“…In the chamber model in mice C. rectus, DNA was found in the maternal liver and placenta of infected dams (Yeo et al 2005). Similarly, P. gingivalis DNA was detected in maternal liver, uterus and placenta of the IUGR foetuses.…”

Section: Evidence From Animal Models and In Vitro Experimentsmentioning

confidence: 89%

Adverse pregnancy outcomes (APOs) and periodontal disease: pathogenic mechanisms

Madianos

Bobetsis

Offenbacher

2013

Journal of Periodontology

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170

127

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Aim: To evaluate the evidence on potential biological pathways underlying the possible association between periodontal disease (PD) and adverse pregnancy outcomes (APOs). Material & Methods: Human, experimental and in vitro studies were evaluated. Results: Periodontal pathogens/byproducts may reach the placenta and spread to the foetal circulation and amniotic fluid. Their presence in the foeto‐placental compartment can stimulate a foetal immune/inflammatory response characterized by the production of IgM antibodies against the pathogens and the secretion of elevated levels of inflammatory mediators, which in turn may cause miscarriage or premature birth. Moreover, infection/inflammation may cause placental structural changes leading to pre‐eclampsia and impaired nutrient transport causing low birthweight. Foetal exposure may also result in tissue damage, increasing the risk for perinatal mortality/morbidity. Finally, the elicited systemic inflammatory response may exacerbate local inflammatory responses at the foeto‐placental unit and further increase the risk for APOs. Conclusions: Further investigation is still necessary to fully translate the findings of basic research into clinical studies and practice. Understanding the systemic virulence potential of the individual's oral microbiome and immune response may be a distinctly different issue from categorizing the nature of the challenge using clinical signs of PD. Therefore, a more personalized targeted therapy could be a more predictive answer to the current “one‐size‐fits‐all” interventions.

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Section: Evidence From Animal Models and In Vitro Experimentsmentioning

confidence: 89%

Adverse pregnancy outcomes (APOs) and periodontal disease: pathogenic mechanisms

Madianos

Bobetsis

Offenbacher

2013

Journal of Periodontology

Self Cite

170

127

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“…As previously mentioned, C. rectus 314, like C. jejuni, has been shown to invade eukaryotic cells, including placental trophoblasts [23]. Invasion of placental trophoblasts is important, as previous studies have suggested that C. rectus plays a significant role in the preterm labors of mothers with periodontitis [10,11] and has the ability to translocate to the placenta, from a distant site of infection, in mouse models of periodontitis.…”

Section: Discussionmentioning

confidence: 89%

“…Serological data from human studies has implied that C. rectus, as part of the poly-microbial oral community, plays a role in the preterm labors of mothers with periodontitis [8]. Additionally, a pregnant mouse model has shown the association of C. rectus strain 314, isolated from a patient with periodontitis [9], with fetal growth restriction and a decreased survival of pups [10,11]. Although the aforementioned human and mouse studies have established C. rectus as an agent of periodontitis, the pathogenic mechanisms of C. rectus are not well elucidated.…”

Section: Introductionmentioning

confidence: 99%

Identification and Characterization of an Invasion Antigen B Gene from the Oral Pathogen Campylobacter rectus

LaGier

Threadgill

2013

Indian J Microbiol

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The oral bacterium, Campylobacter rectus, is an etiological agent of periodontitis. The virulence genes of C. rectus are largely unknown. The aim of this study was to query C. rectus for the presence of an invasion antigen B (ciaB) gene, which is needed for cell invasion by the related species Campylobacter jejuni. PCR and PCRwalking identified a ciaB from C. rectus. In silico analyses of C. rectus 314 ciaB (Cr-ciaB) revealed an ORF of 1,830 base pairs. The Cr-CiaB protein shared significant sequence identity (BLASTx and phylogeny) with CiaB from related campylobacters. Cr-CiaB is predicted to lack membrane helices, signal peptides, and localizes to the cytoplasm; which are consistent with CiaB proteins. Expression of Cr-ciaB was confirmed with RT-PCR; and potential ciaB genes were detected in eight additional strains of C. rectus. Cr-ciaB is the first CiaB identified from the oral campylobacters.

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“…La evidencia experimental así lo demuestra [64][65][66][67] , pues cuando se expusieron ratones hembra a la infección con C. rectus, los fetos pesaron menos (0.49 ± 0.05 gr) y midieron menos (14.69 ± 0.56 mm) en comparación con el grupo control (0.53 ± 0.04 g; 15.54 ± 0.63 mm). Para confirmar la evidencia, C. rectus fue detectado por PCR en las placentas de los animales 68 . La infección logra explicar en parte ambas condiciones (periodontitis, complicaciones del embarazo), pero la respuesta inflamatoria resulta un evento biológico determinante.…”

Section: Importancia De La Infección E Inflamación Periodontal Durantunclassified

Aplicación De Un Modelo Biopsicosocial Para La Reducción De La Morbilidad Y La Mortalidad Materna Y Perinatal en Colombia

M¹,

Cáceres

Gracia

et al. 2009

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Campylobacter rectus Mediates Growth Restriction in Pregnant Mice

Abstract: Remote subcutaneous maternal C. rectus infection increases fetal resorptions and fetal growth restriction in a mouse model. The effects of an oral C. rectus infection on pregnancy remain to be determined.

Cited by 45 publications

References 24 publications

Adverse pregnancy outcomes (APOs) and periodontal disease: pathogenic mechanisms

Adverse pregnancy outcomes (APOs) and periodontal disease: pathogenic mechanisms

Identification and Characterization of an Invasion Antigen B Gene from the Oral Pathogen Campylobacter rectus

Aplicación De Un Modelo Biopsicosocial Para La Reducción De La Morbilidad Y La Mortalidad Materna Y Perinatal en Colombia

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