Campylobacter-Associated Diseases in Animals

Abstract

Campylobacter includes a group of genetically diverse species causing a range of diseases in animals and humans. The bacterium is frequently associated with two economically important and epidemiologically distinct reproductive diseases in ruminants: enzootic infectious infertility in cattle owing to Campylobacter fetus subsp. venerealis and abortions in sheep, goats, and cattle. Septic abortion, usually epizootic in sheep, has been historically associated with C. fetus subsp. fetus and to a lesser extent with Campylobacter jejuni. However, there has been a dramatic species shift in the etiology of Campylobacter abortions in recent years: C. jejuni has now replaced C. fetus subsp. fetus as the predominant cause of sheep abortion in the United States, which appears to be driven primarily by clonal expansion of a hypervirulent tetracycline-resistant C. jejuni clone. Here we provide a review on the recent advances in understanding the pathobiology of Campylobacter infections in animals, with an emphasis on the diseases in ruminants, covering epidemiology, pathogenesis, genomics, and control measures.

Campylobacter fetus impairs barrier function in HT‐29/B6 cells through focal tight junction alterations and leaks

“…coli infections and comprise reactive arthritis, Guillian‐Barré syndrome, and postinfectious irritable bowel syndrome. Additionally, bacteremia and abortion are rarely reported in C. jejuni infection . In young children, growth reduction can occur depending on the number and duration of inflammatory diarrheal episodes from Campylobacter spp.…”

“…Additionally, bacteremia and abortion are rarely reported in C. jejuni infection. 41 In young children, growth reduction can occur depending on the number and duration of inflammatory diarrheal episodes from Campylobacter spp. infections (MAL-ED studies).…”

High Prevalence of Fluoroquinolone-Resistant Campylobacter Bacteria in Sheep and Increased Campylobacter Counts in the Bile and Gallbladders of Sheep Medicated with Tetracycline in Feed

“…These findings provide new information on Campylobacter epidemiology in sheep, which may be useful for curbing the spread of antibiotic-resistant Campylobacter in animal reservoirs. KEYWORDS Campylobacter, antimicrobial resistance, fluoroquinolone, genotype, sheep C ampylobacter species, particularly Campylobacter jejuni and Campylobacter coli, are a leading cause of bacterial foodborne gastroenteritis in humans around the world (1)(2)(3). Among all the causes of laboratory-confirmed bacterial foodborne illnesses, Campylobacter was the leading cause (19.2 per 100,000 population) in the year 2017, based on a report by the Centers for Disease Control and Prevention (CDC) FoodNet surveillance program in the United States (4).…”

“…Typically, Campylobacter colonizes the intestinal tract in animals, but it may also translocate across the intestinal epithelial barrier and causes systemic infection, leading to bacteremia and abortion in ruminants and even occasionally in humans (1,22). In fact, Campylobacter is the major cause of ovine abortions worldwide, including in the United States.…”

Estudio de los caracteres epidemiológicos y control experimental de "Campylobacter jejuni" en el entorno de la producción de pollos para carne = Study of the epidemiological characteristics and experimental control of "Campylobacter jejuni" in the area of poultry for meat production

“…A pesar de que C. jejuni se localiza principalmente en el tracto intestinal de las aves, este microorganismo se encuentra muy difundido en la naturaleza, bien adaptado a varias especies animales (Sahin et al, 2017), pudiendo actuar algunas de ellas como reservorios del microorganismo (Ellis-Iversen et al, 2012;Santos et al, 2012). En este estudio se analizó la prevalencia de C. jejuni en diferentes animales que se hallaban en el entorno de aves positivas.…”