<i>Brucella canis</i>Causing Infection in an HIV-Infected Patient

Lucero, Nidia E.; Maldonado, Patricia; Kaufman, Sara; Escobar, Gabriela I.; Boeri, Eduardo; Jacob, N.

doi:10.1089/vbz.2009.0034

Cited by 32 publications

(33 citation statements)

References 8 publications

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“…However, clinical signs did not develop in four adults in the same household, all of whom had been exposed to the puppy (Dentinger et al, ). Several recent reports have suggested that B. canis in HIV‐infected patients highlights the high risk within this population (Lucero, Maldonado, et al, ; Moreno et al, ). Our conclusion is consistent with aetiological characteristics of B. canis in China .…”

Section: Discussionmentioning

confidence: 99%

Investigation of the molecular epizootiological characteristics and tracking of the geographical origins ofBrucella canisstrains in China

Liu

Wang

et al. 2019

Transbound Emerg Dis

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Brucellosis is a global pandemic infectious zoonosis. Brucella canis is a rare source of human brucellosis in China, and its public health significance remains under debate. Moreover, data pertaining to the epizootiological characteristics and geographical origin of B. canis on a nationwide scale are limited, and the risk to public safety posed by B. canis infections is unknown. The MLVA (multilocus variable‐number tandem repeat analysis) assay can be helpful to analyse epidemiological correlations among Brucella isolates and to track their geographic origins. To accomplish this task, MLVA‐16 was used to analyse the epidemiological links of 63 isolates obtained from dogs and humans. Sixty‐three B. canis strains were sorted into three large clusters (A, B and C) and 50 different genotypes (GT1–50), and 43 unique genotypes were represented by single isolates, suggesting that these strains had no obvious epidemiological links and that canine brucellosis is predominantly sporadic in China. The other seven shared genotypes (among a total of 20 isolates) were each represented by two to eight isolates, indicating that strains from each shared genotype were epidemiologically correlated. Five of the shared genotypes were from 16 strains obtained from Beijing, indicating that canine brucellosis in Beijing originates from multipoint outbreaks with multiple sources of infection. Based on comprehensive case analysis of clinical B. canis infection, we preliminarily suggest that human B. canis infections are associated with Mycoplasma pneumoniae infection that results in decreased patient immunity. B. canis may have limited epidemiological significance for the healthy population, but it remains a significant threat to the canine breeding industry and to humans who come into close contact with dogs. Based on MLVA‐11 data, B. canis strains were clustered into 16 genotypes and divided into five evolutionary branches; these data confirm that this population covers an extensive geographic area and exhibits characteristics of the origin and evolution of co‐existing introduced and locally native lineages. We believe this study will contribute to strengthening efforts to prevent and control canine brucellosis and to improve public understanding of the health risks posed by B. canis.

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Section: Discussionmentioning

confidence: 99%

Investigation of the molecular epizootiological characteristics and tracking of the geographical origins ofBrucella canisstrains in China

Liu

Wang

et al. 2019

Transbound Emerg Dis

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“…Two recent cross-sectional seroprevalence studies in Iran have shown an association between HIV and brucellosis seroprevalence. 56,57 Case reports have proposed an association between HIV and B. canis, 58,59 and between HIV and relapsing brucellosis. 60 Consistent with our study, others have found no association between HIV and brucellosis.…”

Section: Discussionmentioning

confidence: 99%

Brucellosis among Hospitalized Febrile Patients in Northern Tanzania

Bouley

Biggs²,

Stoddard³

et al. 2012

The American Journal of Tropical Medicine and Hygiene

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Abstract. Acute and convalescent serum samples were collected from febrile inpatients identified at two hospitals in Moshi, Tanzania. Confirmed brucellosis was defined as a positive blood culture or a 4-fold increase in microagglutination test titer, and probable brucellosis was defined as a single reciprocal titer 160. Among 870 participants enrolled in the study, 455 (52.3%) had paired sera available. Of these, 16 (3.5%) met criteria for confirmed brucellosis. Of 830 participants with 1 serum sample, 4 (0.5%) met criteria for probable brucellosis. Brucellosis was associated with increased median age (P = 0.024), leukopenia (odds ratio [OR] 7.8, P = 0.005), thrombocytopenia (OR 3.9, P = 0.018), and evidence of other zoonoses (OR 3.2, P = 0.026). Brucellosis was never diagnosed clinically, and although all participants with brucellosis received antibacterials or antimalarials in the hospital, no participant received standard brucellosis treatment. Brucellosis is an underdiagnosed and untreated cause of febrile disease among hospitalized adult and pediatric patients in northern Tanzania.

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“…Despite the apparent poor association between HIV and brucellosis and that the impression that HIV infection does not seem to increase the incidence of brucellosis, several cases as well as case series on the development of brucellosis in HIV infected individuals have been reported [86,[160][161][162][163][164][165][166]. The risk factors for Brucella infection in HIV patients are male sex and intravenous drug abuse [162,163].…”

Section: Brucellosis In Patients With Hiv Infectionmentioning

confidence: 99%