Bifidobacterium bifidum FJSWX19M5 alleviated 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced chronic colitis by mitigating gut barrier injury and increasing regulatory T cells

Abstract

Probiotics have been evaluated as alternative approaches to preventing relapse of Crohn's disease (CD). Previously, we observed strain-specific anti-inflammatory properties of Bifidobacterium bifidum in 2,4,6-trinitrobenzene sulfonic acid (TNBS) acute colitis...

Mechanistic insights into the role of probiotics in modulating immune cells in ulcerative colitis

“…125 The study conducted by Qu and colleagues provided evidence that the administration of FJSWX19M5 resulted in the augmentation of Tregs and had a role in the recovery of the intestinal barrier. 69 This observation implies that FJSWX19M5 could possess immunomodulatory characteristics that contribute to regulating the immune response inside the gastrointestinal tract. Additionally, it was shown that the co-cultivation of B. bifidum strains with anticolitis capabilities induced an elevation in the expression of the cytokine that inhibits inflammation IL-10 and a decreased ratio of proinflammatory cytokines (IL-22/IL-10 and IL-17/IL-10) as compared to nonprotective strains.…”

“…This implies that the advantageous strains have the potential to regulate the immune response in a manner that decreases inflammation associated with colitis. 69 Furthermore, the findings of Qu and colleagues showed that the injection of heat-killed FJSWX19M5 positively impacted symptoms associated with colitis. This suggests that the therapeutic effects of this treatment may not only depend on the presence of live bacteria.…”

“…Qu and colleagues conducted new research to evaluate the therapeutic efficacy of certain strains of B. bifidum for managing chronic colitis. The focus of the study was primarily on controlling and preventing colitis in the setting of CD 69 . The impact of FJSWX19M5 treatment on the histology of the colonic mucosa is vital because achieving endoscopic mucosal healing is often regarded as the most reliable indicator of long‐term remission in the clinical arena of CD therapy 121 .…”

“…The focus of the study was primarily on controlling and preventing colitis in the setting of CD. 69 The impact of FJSWX19M5 treatment on the histology of the colonic mucosa is vital because achieving endoscopic mucosal healing is often regarded as the most reliable indicator of long-term remission in the clinical arena of CD therapy. 121 The observed protective benefits of some probiotics may be partially attributable to their ability to regulate the function of the intestinal barrier, particularly the tight junction (TJ) function and the formation of mucin.…”

“…During the tests, significant favorable effects were observed in the B. bifidum strain FJSWX19M5. The intervention provided relief from body weight loss, mitigated colonic shortening and damage, reduced gut inflammation indicators, and restored colonic metabolism equilibrium in mice afflicted with TNBS‐induced chronic colitis 69 . The bioactive compounds originating from symbiotic microbiota are crucial in forming the intestinal immune system and controlling IL‐10 release 124 …”