Oxyberberine ameliorates TNBS-induced colitis in rats through suppressing inflammation and oxidative stress via Keap1/Nrf2/NF-κB signaling pathways

Li, Cailan; Liu, Meigui; Deng, Li; Luo, Dandan; Ma, Runfang; Lü, Qiang

doi:10.1016/j.phymed.2023.154899

Cited by 17 publications

(3 citation statements)

References 56 publications

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“…It regulates the production of inflammatory mediators, modulates the activity of immune cells, and improves the intracellular oxidative stress status, thereby attenuating the inflammatory process. Nrf2 activation can also suppress inflammatory signalling pathways, such as the NF-κB pathway, resulting in reduced production of inflammatory mediators and cellular damage ( Wang Z. et al, 2023 ; Li et al, 2023 ) and save mitochondrial function by regulating NLRP3 inflammatory bodies ( Rajan et al, 2023 ). In COPD, the inherent loss of metabolic plasticity leads to metabolic failure and decreased redox capacity, which can be rescued by activating the Nrf2 pathway ( Ryan et al, 2023 ).…”

Section: Discussionmentioning

confidence: 99%

Insight into Nrf2: a bibliometric and visual analysis from 2000 to 2022

Ma,

Wang,

2023

Front. Genet.

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Background: Nrf2 plays a pivotal role in governing the antioxidant defense system, triggering the transcription of diverse genes involved in cellular protection. Its role in mitigating oxidative damage and modulating inflammatory processes has made Nrf2 an attractive target for therapeutic interventions. Despite the growing interest in Nrf2 research, a bibliometric analysis is relatively rare. This study aimed to clarify Nrf2’s role in multiple diseases, identify emerging trends and hotspots using bibliometric analysis, and provide valuable insights and potential directions for future therapeutic interventions.Methods: The Science Citation Index of Web of Science Core library from 2000 to 2022 was searched on 22 October 2022. Use Microsoft Excel, CiteSpace, Bibliometrix, and VOS viewers for data collection and visualization of research focus and trends.Results: A vast collection of 22,040 research studies on Nrf2 published between 2000 and 2022 were identified. Nrf2 research has seen significant growth globally from 2000 to 2022. China leaded in publication numbers (9,623, 43.66%), while the United States dominated in citation frequency with 261,776 citations. China Medical University was the most productive institutions (459, 2.08%). Masayuki Yamamoto topped in publications (307), while Itoh K. ranked first in citations with 3669. Free Radical Biology and Medicine was the journal with the most studies and citations on Nrf2 (613, 29,687 citations). The analysis of keyword clustering enhanced the categorization of topics and can be summarized as oxidative stress, cancer, disorders in glycolipid metabolism, inflammation, and neurological conditions.Conclusion: China and the United States are the pioneers in Nrf2 research. Recently, there has been a comprehensive exploration of Nrf2 involving both experimental and clinical aspects, as well as mechanisms and therapeutic applications. Investigating novel molecular mechanisms, including NF-κB, Ho1, and Keap1, and developing enhanced, targeted Nrf2 activators or inhibitors to uncover the interplay among cancer, glycolipid metabolic disorder, inflammation, and neurological disorders will be upcoming trends and hotspots.

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Section: Discussionmentioning

confidence: 99%

Insight into Nrf2: a bibliometric and visual analysis from 2000 to 2022

Ma,

Wang,

2023

Front. Genet.

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“…It has been found in many studies to be closely related to the occurrence and development of IBD [38,39] and can be affected by many factors such as drugs and intestinal microorganisms. For example, oxyberberine improves oxidative stress and mediates nuclear factor kappa B (NF-κB) pathway inhibition, significantly improving UC in rats [40]. The Mediterranean diet is a famous healthy diet, with a small amount of fat (mainly olive oil), candy, red meat, wine, moderate fish, poultry, eggs, and dairy products; it is rich in plant-based food as the main component and is characterized by high amounts of dietary fiber and low levels of saturated fatty acids [41].…”

Section: Discussionmentioning

confidence: 99%

Effect of Dietary Patterns on Inflammatory Bowel Disease: A Machine Learning Bibliometric and Visualization Analysis

et al. 2023

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Aims: This study aimed to analyze the related research on the influence of dietary patterns on IBD carried out over the past 30 years to obtain the context of the research field and to provide a scientific basis and guidance for the prevention and treatment of IBD. Methods: The literature on the effects of dietary patterns on inflammatory bowel disease published over the past three decades was retrieved from the Web of Science Core Collection (WoSCC) database. CiteSpace, VOSviewer, the R software (version 4.3.0) bibliometrix package, the OALM platform, and other tools were used for the analyses. Results: The growth of scientific papers related to this topic can be divided into two stages: before and after 2006. Overall, the growth of the relevant literature was in line with Price’s literature growth curve. Subrata Ghosh and Antonio Gasbarrini are the authors with the highest academic influence in the field, and Lee D.’s research results are widely recognized by researchers in this field. Among the 72 countries involved in the study, the United States contributed the most, while China developed rapidly with regard to research being carried out in this area. From a regional perspective, countries and institutions in North America, Europe, and East Asia have made the most significant contributions to this field and have the closest cooperation. Among the 1074 articles included in the study, the most influential ones tended to consider the mechanism of the effect of dietary patterns on IBD from the perspective of the microbiome. Multiple tools were used for keyword analysis and mutual verification. The results showed that NF-κB, the Mediterranean diet, fatty acids, fecal microbiota, etc., are the focus and trends of current research. Conclusions: A Mediterranean-like dietary pattern may be a good dietary habit for IBD patients. Carbohydrates, fatty acids, and inulin-type fructans are closely related to IBD. Fatty acid, gut microbiota, NF-κB, oxidative stress, and endoplasmic reticulum stress are the hot topics in the study of the effects of dietary patterns on IBD and will be emerging research trends.

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“…The dose selection was based on previous investigations and our pilot trial. 7 , 41 After administration, heparinized tubes were used to collect 250 μL of blood from the orbital vein at different predetermined intervals (0.083, 0.166, 0.25, 0.5, 1, 2, 3, 4, 5, 6, 7, 8, 12, and 24 h). The acetonitrile protein precipitation method was used to treat all the blood samples.…”

Section: Methodsmentioning

confidence: 99%

Supersaturated Drug Delivery System of Oxyberberine Based on Cyclodextrin Nanoaggregates: Preparation, Characterization, and in vivo Application

Huang,

Zhang,

Qin

et al. 2024

IJN

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Oxyberberine ameliorates TNBS-induced colitis in rats through suppressing inflammation and oxidative stress via Keap1/Nrf2/NF-κB signaling pathways

Cited by 17 publications

References 56 publications

Insight into Nrf2: a bibliometric and visual analysis from 2000 to 2022

Insight into Nrf2: a bibliometric and visual analysis from 2000 to 2022

Effect of Dietary Patterns on Inflammatory Bowel Disease: A Machine Learning Bibliometric and Visualization Analysis

Supersaturated Drug Delivery System of Oxyberberine Based on Cyclodextrin Nanoaggregates: Preparation, Characterization, and in vivo Application

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