<i>Berberis vulgaris</i> root bark extract prevents hyperoxaluria induced urolithiasis in rats

Bashir, Samra; Gilani, Anwarul Hassan; Siddiqui, Anwar Ali; Pervez, Shahid; Khan, Saeed R.; Sarfaraz, Noor Jehan; Shah, Abdul Jabbar

doi:10.1002/ptr.3196

Cited by 45 publications

(26 citation statements)

References 29 publications

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“…[22] It was observed in the present study that administration of ethylene glycol increased MDA content of kidneys and decreased activity of the antioxidant enzymes in the kidneys. The EHV treatment protected against the changes associated with oxidative stress.…”

Section: Discussionmentioning

confidence: 54%

Antiurolithiatic and antioxidant activity of Hordeum vulgare seeds on ethylene glycol-induced urolithiasis in rats

Shah¹,

Patel²,

Patel³

et al. 2012

Indian J Pharmacol

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Objective:The objective was to investigate the antiurolithiatic and antioxidant activity of ethanolic extract of Hordeum vulgare seeds (EHV) on ethylene glycol-induced urolithiasis in Wistar albino rats.Materials and Methods:Urolithiasis was produced in Wistar albino rats by adding 0.75% v/v ethylene glycol (EG) to drinking water for 28 days. The ethanolic extract of Hordeum vulgare seeds (EHV) was assessed for its curative and preventive action in urolithiasis. In preventive treatment, the EHV given from 1st day to 28th day, while in the curative regimen, the EHV was given from 15th day to 28th day. Various renal functional and injury markers such as urine volume, calcium, phosphate, uric acid, magnesium, urea, and oxalate were evaluated using urine, serum, and kidney homogenate. Antioxidant parameters such as lipid peroxidation, superoxide dismutase, and catalase were also determined.Results:The EHV treatment (both preventive and curative) increased the urine output significantly compared to the control. The EHV treatment significantly reduced the urinary excretion of the calcium, phosphate, uric acid, magnesium, urea, and oxalate and increased the excretion of citrate compared to EG control. The increased deposition of stone forming constituents in the kidneys of calculogenic rats were significantly lowered by curative and preventive treatment with EHV. It was also observed that the treatment with EHV produced significant decrease in lipid peroxidation, and increased levels of superoxide dismutase and catalase.Conclusion:These results suggest the usefulness of ethanolic extract of Hordeum vulgare seeds as an antiurolithiatic and antioxidant agent.

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Section: Discussionmentioning

confidence: 54%

Antiurolithiatic and antioxidant activity of Hordeum vulgare seeds on ethylene glycol-induced urolithiasis in rats

Shah¹,

Patel²,

Patel³

et al. 2012

Indian J Pharmacol

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“…It is therefore pertinent to investigate the effect of coconut water in nephrocalcinosis model of male Wistar rats. Some investigators (21,25) have studied various natural therapeutic agents in vivo A B animal models. In the present study, efficacy of coconut water was evaluated on ethylene glycol induced nephrocalcinosis in male Wistar rats.…”

Section: Discussionmentioning

confidence: 99%

Prophylactic effect of coconut water (Cocos nucifera L.) on ethylene glycol induced nephrocalcinosis in male wistar rat

et al. 2013

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Purpose: Many medicinal plants have been employed during ages to treat urinary stones though the rationale behind their use is not well established. Thus, the present study was proposed to evaluate the effect of coconut water as a prophylactic agent in experimentally induced nephrolithiasis in a rat model. Materials and Methods:The male Wistar rats were divided randomly into three groups. Animals of group I (control) were fed standard rat diet. In group II, the animals were administrated 0.75% ethylene glycol in drinking water for the induction of nephrolithiasis. Group III animals were administrated coconut water in addition to ethylene glycol. All the treatments were continued for a total duration of seven weeks. Results and Conclusion: Treatment with coconut water inhibited crystal deposition in renal tissue as well as reduced the number of crystals in urine. Furthermore, coconut water also protected against impaired renal function and development of oxidative stress in the kidneys. The results indicate that coconut water could be a potential candidate for phytotherapy against urolithiasis.

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“…Further, it is associated with a high recurrence rate [1]. Stones composed of calcium oxalate (CaOx), either alone or mixed with calcium phosphate, are hitherto the most common uroliths, accounting for more than 80% of stones [2].…”

Section: Introductionmentioning

confidence: 99%

Calcium Oxalate Induces Renal Injury through Calcium‐Sensing Receptor

Shi

et al. 2016

Oxidative Medicine and Cellular Longevity

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Objective. To investigate whether calcium-sensing receptor (CaSR) plays a role in calcium-oxalate-induced renal injury. Materials and Methods. HK-2 cells and rats were treated with calcium oxalate (CaOx) crystals with or without pretreatment with the CaSR-specific agonist gadolinium chloride (GdCl3) or the CaSR-specific antagonist NPS2390. Changes in oxidative stress (OS) in HK-2 cells and rat kidneys were assessed. In addition, CaSR, extracellular signal-regulated protein kinase (ERK), c-Jun N-terminal protein kinase (JNK), and p38 expression was determined. Further, crystal adhesion assay was performed in vitro, and the serum urea and creatinine levels and crystal deposition in the kidneys were also examined. Results. CaOx increased CaSR, ERK, JNK, and p38 protein expression and OS in vitro and in vivo. These deleterious changes were further enhanced upon pretreatment with the CaSR agonist GdCl3 but were attenuated by the specific CaSR inhibitor NPS2390 compared with CaOx treatment alone. Pretreatment with GdCl3 further increased in vitro and in vivo crystal adhesion and renal hypofunction. In contrast, pretreatment with NPS2390 decreased in vitro and in vivo crystal adhesion and renal hypofunction. Conclusions. CaOx-induced renal injury is related to CaSR-mediated OS and increased mitogen-activated protein kinase (MAPK) signaling, which subsequently leads to CaOx crystal adhesion.

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Berberis vulgaris root bark extract prevents hyperoxaluria induced urolithiasis in rats

Cited by 45 publications

References 29 publications

Antiurolithiatic and antioxidant activity of Hordeum vulgare seeds on ethylene glycol-induced urolithiasis in rats

Antiurolithiatic and antioxidant activity of Hordeum vulgare seeds on ethylene glycol-induced urolithiasis in rats

Prophylactic effect of coconut water (Cocos nucifera L.) on ethylene glycol induced nephrocalcinosis in male wistar rat

Calcium Oxalate Induces Renal Injury through Calcium‐Sensing Receptor

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