<i>Aspergillus terreus</i>Infection of Pseudoaneurysm of Aortofemoral Vascular Graft with Contiguous Vertebral Osteomyelitis

Glotzbach, Raymond E.

doi:10.1093/ajcp/77.2.224

Cited by 60 publications

(28 citation statements)

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“…Half of the patients survived their infection which was usually treated with amphotericin B plus surgical debridement. Three additional reports have appeared subsequently in which vertebral osteomyelitis has followed laminectomies, and four cases have been associated with infected aortic grafts in which infection has extended from pseudo-aneurysms (171,172). In several cases the fungus invaded the anterior spinal artery causing thrombosis, liquefaction of the spinal cord and paraplegia.…”

Section: Invasive Pulmonary Infection Invasive Aspergillusmentioning

confidence: 99%

Aspergillosis

Bodey

Vartivarian

1989

Eur. J. Clin. Microbiol. Infect. Dis.

302

228

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Aspergillus spores are ubiquitous in the environment and may become concentrated in hospital ventilation systems. Colonization in normal hosts can lead to allergic diseases ranging from asthma to allergic bronchopulmonary aspergillosis. Normal hosts rarely develop invasive disease, which is primarily an infection of severely immunocompromised patients. The major predisposing factors for infection include prolonged neutropenia, chronic administration of adrenal corticosteroids, the insertion of prosthetic devices, and tissue damage due to prior infection or trauma. Since Aspergillus spp. are respiratory pathogens, the most common form of infection is pneumonia followed by sinusitis. Patients with preexistant cavitary disease may develop noninvasive aspergillomas. Most infections are caused by Aspergillus fumigatus. The organism is capable of invading across all natural barriers, including cartilage and bone. It has a propensity for invading blood vessels causing thrombosis and infarction. The diagnosis of pulmonary infection is usually difficult to establish because the organism is seldom cultured from sputum and can represent contamination in some cases. Therapy is immunocompromised hosts is less than satisfactory and amphotericin B is the only agent with significant activity. There is anecdotal evidence to suggest that the addition of 5-fluorocytosine to amphotericin B may be beneficial.

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Section: Invasive Pulmonary Infection Invasive Aspergillusmentioning

confidence: 99%

Aspergillosis

Bodey

Vartivarian

1989

Eur. J. Clin. Microbiol. Infect. Dis.

302

228

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“…Fungal infections of vascular grafts are even less frequent [2,[4][5][6][7][8][9][10][11][12][13][14][15][16]. In fact, invasive aspergillosis is more frequent among immunocompromised individuals receiving chemo-or corticotherapy and AIDS patients.…”

Section: Discussionmentioning

confidence: 99%

True mycotic false aneurysm due to aspergillus: Three lesions in two cases and literature review

et al. 2011

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Mycotic infection of the blood vessels is extremely rare and is associated more frequently with the presence of a vascular prosthetic graft. In this article we report three cases of pseudoaneurysm formation due to Aspergillus infection in two kidney transplant recipients receiving kidneys from the same donor. Some considerations and a brief review of the literature and discussion of the existent reported cases are presented.

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“…Cardiac surgery is the major predisposing factor for Aspergillus endocarditis. Infection of vascular grafts also is presumed to be acquired intraoperatively, but like endocarditis, may remain undiagnosed for a long period of time [78] . However, not all cases of aspergillosis endocarditis are associated with surgery [79,80] .…”

Section: Cardiovascular Aspergillosismentioning

confidence: 99%

Comparative Clinicopathological Manifestations of Human Aspergillosis

2004

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Aspergillus species are important fungi of the environment, some of them being responsible for severe infections. Many distinct diseases form the human aspergillosis spectrum. The pathomechanisms differ according to the affected organ and the immune status of the patient. The fungus can be responsible for allergic reactions. It may also act as a saprophytic colonizer of air spaces. Infection may remain limited to the skin and nails. It may also be invasive, particularly in immunocompromised patients, in the lungs, paranasal sinus and gastrointestinal tract. Hematogeneous disseminated aspergillosis represents another dramatic form of the disease.

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Aspergillus terreusInfection of Pseudoaneurysm of Aortofemoral Vascular Graft with Contiguous Vertebral Osteomyelitis

Cited by 60 publications

References 0 publications

Aspergillosis

Aspergillosis

True mycotic false aneurysm due to aspergillus: Three lesions in two cases and literature review

Comparative Clinicopathological Manifestations of Human Aspergillosis

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