<i>Anaplasma phagocytophilum</i>Antibodies in Humans, Japan, 2010–2011

Gaowa,; Yoshikawa, Yuko; Ohashi, Norio; Wu, Dongxing; Kawamori, Fumihiko; Ikegaya, Asaka; Watanabe, Takahiro; Saitoh, K; Takechi, Daisuke; Murakami, Youichi; Shichi, Daisuke; Aso, Katsumi; Ando, Shuji

doi:10.3201/eid2003.131337

Cited by 12 publications

(3 citation statements)

References 10 publications

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“…According to a study on HGA patients in Japan 20 , differences were found in the major surface antigen proteins, depending on the cell line (THP-1 and HL60) used for IFA and western blotting in HGA diagnosis. Therefore, it was reported that the test results could be different depending on the cultured cell line.…”

Section: Discussionmentioning

confidence: 99%

Human granulocytic anaplasmosis in a Single University Hospital in the Republic of Korea

Kim

Seo

Yun

et al. 2021

Sci Rep

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To date, only a few studies have analyzed the clinical characteristics and genetic features of human granulocytic anaplasmosis (HGA) in South Korea. Thus, in this study, we investigated the clinical characteristics of HGA and methods used for clinical diagnosis. The clinical characteristics of patients with HGA were studied retrospectively. We reviewed the medical charts of 21 confirmed patients with HGA admitted to the Chosun University Hospital, located in Gwangju, South Korea. Twenty-one HGA patients visited the hospital 2–30 days (median 7 days) after the onset of symptoms. Fourteen patients (66.7%) had fever, which was alleviated 2 h (range 0–12.75 h) after starting treatment with doxycycline. Of the 18 patients who underwent peripheral blood (PB) smear test, only one (5.6%) had morulae. Additionally, only 4/17 patients (23.5%) had morulae in the PB smear reconducted after the confirmation of anaplasmosis. All 21 patients recovered without significant complications. As per results of the blood tests conducted at the time of admission, 7/21 (33.3%) and 5/21 (23.8%) patients showed at least 1:16 and 1:80 of IgM and IgG titers, respectively. Most HGA patients in Korea recovered without significant complications. The indirect immunofluorescence antibody diagnosis or morulae identification for HGA in this study had low sensitivity in the early stage of the disease.

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Section: Discussionmentioning

confidence: 99%

Human granulocytic anaplasmosis in a Single University Hospital in the Republic of Korea

Kim

Seo

Yun

et al. 2021

Sci Rep

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“…has also been reported in Thoroughbred horses in Hidaka district, Hokkaido [62]. Recently, 2 cases of HGA in 2013 [60] and additional 4 cases in 2014 [63] were confirmed in Japan. Infected patients showed fever, chills, headache, and malaise.…”

Section: Introductionmentioning

confidence: 83%

Anaplasma species of veterinary importance in Japan

Ybañez

Inokuma

2016

Vet World

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Anaplasma species of the family Anaplasmataceae, order Rickettsiales are tick-borne organisms that can cause disease in animals and humans. In Japan, all recognized species of Anaplasma (except for Anaplasma ovis) and a potentially novel Anaplasma sp. closely related to Anaplasma phagocytophilum have been reported. Most of these detected tick-borne pathogens are believed to be lowly pathogenic in animals in Japan although the zoonotic A. phagocytophilum has recently been reported to cause clinical signs in a dog and in humans. This review documents the studies and reports about Anaplasma spp. in Japan.

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“…Las ehrlichiosis son enfermedades zoonóticas y emergentes (Vu hai et al, 2014), causadas por bacterias Gram negativas e intracelulares obligadas. En humanos destacan Ehrlichia chaffensis y Anaplasma phagoytophilum (A. phagocytophilum) (Anaya et al, 2009;Gaowa et al, 2014). Debido a las reacciones cruzadas que existen entre rickettsias y ehrlichias (Oteo y Brouqui, 2005), A. phagocytophilum se referirá como Anaplasma spp en la presente investigación.…”

Section: Introductionunclassified

Anticuerpos anti-Anaplasma spp en población de riesgo ocupacional de un hospital veterinario

Weinborn¹,

Zanelli²,

López³

et al. 2018

Rev. investig. vet. Perú

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El estudio tuvo como objetivo estimar la seroprevalencia de anticuerpos contra Anaplasma spp en estudiantes y personal del Hospital Clínico Veterinario Docente (HCVD) de la Escuela de Medicina Veterinaria de la Universidad Santo Tomás (UST), Talca, Chile. Se analizaron 58 muestras sanguíneas humanas mediante inmunofluorescencia indirecta (IFI) para IgG. Se utilizó el test exacto de Fischer o X2 para evaluar diferencias significativas (p<0.05) y el índice de Kappa para evaluar concordancia entre IFI y signología clínica. Se obtuvo el 25.9% de seropositividad a Anaplasma spp, encontrándose diferencias significativas en uso de medidas de bioseguridad, extracción de garrapatas y hallazgos de ectoparásitos en ropa. El índice Kappa fue de 0.13.

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Anaplasma phagocytophilumAntibodies in Humans, Japan, 2010–2011

Cited by 12 publications

References 10 publications

Human granulocytic anaplasmosis in a Single University Hospital in the Republic of Korea

Human granulocytic anaplasmosis in a Single University Hospital in the Republic of Korea

Anaplasma species of veterinary importance in Japan

Anticuerpos anti-Anaplasma spp en población de riesgo ocupacional de un hospital veterinario

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