<i>Akkermansia muciniphila</i> ameliorates depressive disorders in a murine alcohol-LPS (mALPS) model

Guo, Dingming; Park, Chaiwoo; Li, Yun; Li, Bei; Yang, Qianqian; Deng, Yanfei; Gao, Na; Li, Rong; Wang, Xiangfeng; Yi, Liwen; Liu, Zhi

doi:10.1039/d2fo01478e

Cited by 17 publications

(16 citation statements)

References 55 publications

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“…Therefore, Akkermansia may be a key genus in the regulation of inflammatory senescence. Akkermansia has also been shown to improve the intestinal barrier, preventing lipopolysaccharide from entering the bloodstream . However, we did not investigate the health of the volunteers’ intestinal barrier in this paper.…”

Section: Discussionmentioning

confidence: 99%

Using Inflammatory Biological Age To Evaluate the Preventing Aging Effect of a Polyphenol-Probiotic-Enhanced Dietary Pattern in Adults Aged 50 Years and Older

Meng

Zhou²,

Zhang

et al. 2023

J. Agric. Food Chem.

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A high-compliance dietary intervention was conducted for 2 weeks in adults aged 50 years and older to investigate the preventing aging effects of a polyphenol-probiotic-enhanced diet (P-diet) by using inflammatory biological age (IBA). Following the P-diet, levels of interleukin-6 (IL-6), IL-10, and C-reactive protein were reduced. These effects were accompanied by a significant increase in the richness of Lactobacillus and Bifidobacterium and decrease in CAG_56, as well as an increase in butyrate and acetate and decrease in lysine, uracil, and valine. We optimized a model by a back propagation artificial neural network to evaluate the degree of aging, with an R 2 of 0.68. After the P-diet intervention, IBA was younger than chronological age and the inflammatory aging potential (Δage) was observably reduced by 90.12%, with change in Δage having a direct negative association with Akkermansia. Overall, P-diet may alleviate chronic low-grade inflammation and thus prevent the procession of inflammatory aging.

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Section: Discussionmentioning

confidence: 99%

Using Inflammatory Biological Age To Evaluate the Preventing Aging Effect of a Polyphenol-Probiotic-Enhanced Dietary Pattern in Adults Aged 50 Years and Older

Meng

Zhou²,

Zhang

et al. 2023

J. Agric. Food Chem.

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“… Xie et al (2020) carried out 2-week electroacupuncture intervention in mice, and found that electroacupuncture could inhibit proinflammatory shift with promoting the recovery of the relative abundance of Akkermansia , Clostridium , Lactococcus, and Butyricimonas in the intestinal tract, and significantly increase the relative abundance of Lactobacillus . A number of bacteria above are capable of inhibiting inflammation, protecting the intestinal barrier and preventing depression ( Guo et al, 2022 ; Lai et al, 2022 ; Ramalho et al, 2022 ). All of the above bacteria have the potential to inhibit inflammation, protect the intestinal barrier, and prevent depression ( Guo et al, 2022 ; Lai et al, 2022 ; Ramalho et al, 2022 ).…”

Section: Acupuncture Regulates Intestinal Microbiota In Psdmentioning

confidence: 99%

“…A number of bacteria above are capable of inhibiting inflammation, protecting the intestinal barrier and preventing depression ( Guo et al, 2022 ; Lai et al, 2022 ; Ramalho et al, 2022 ). All of the above bacteria have the potential to inhibit inflammation, protect the intestinal barrier, and prevent depression ( Guo et al, 2022 ; Lai et al, 2022 ; Ramalho et al, 2022 ). It can be seen that acupuncture alleviates systemic inflammation in rats overall through the increase in beneficial microorganisms’ abundance.…”

Section: Acupuncture Regulates Intestinal Microbiota In Psdmentioning

confidence: 99%

“…Pro-inflammatory cytokines (TNF-α and IL-1β) and LPS may induce depressive symptoms and are the most reliable biomarkers for the presence of inflammation in depressed patients ( Spalletta et al, 2006 ; Maes et al, 2008 ; Miller et al, 2009 ). Researchers have proven that intestinal barrier destruction in depression is related to an increase in proinflammatory factors like LPS and TNF-α and IL-1β ( Guo et al, 2022 ). As a consequence of acupuncture, significant reductions in LPS, TNF-α, and IL-1β in serum and brain were observed, and Zhang et al (2022d) hypothesized that this was the result of manual acupuncture restoring the intestinal barrier and reducing inflammation by regulating the intestinal flora.…”

Section: Acupuncture Regulates Intestinal Microbiota In Psdmentioning

confidence: 99%

“…intestinal barrier and preventing depression (Guo et al, 2022;Lai et al, 2022;Ramalho et al, 2022). All of the above bacteria have the potential to inhibit inflammation, protect the intestinal barrier, and prevent depression (Guo et al, 2022;Lai et al, 2022;Ramalho et al, 2022).…”

Section: Regulation Of Intestinal Microbial Structurementioning

confidence: 99%

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Acupuncture treatment for post-stroke depression: Intestinal microbiota and its role

et al. 2023

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Stroke-induced depression is a common complication and an important risk factor for disability. Besides psychiatric symptoms, depressed patients may also exhibit a variety of gastrointestinal symptoms, and even take gastrointestinal symptoms as the primary reason for medical treatment. It is well documented that stress may disrupt the balance of the gut microbiome in patients suffering from post-stroke depression (PSD), and that disruption of the gut microbiome is closely related to the severity of the condition in depressed patients. Therefore, maintaining the balance of intestinal microbiota can be the focus of research on the mechanism of acupuncture in the treatment of PSD. Furthermore, stroke can be effectively treated with acupuncture at all stages and it may act as a special microecological regulator by regulating intestinal microbiota as well. In this article, we reviewed the studies on changing intestinal microbiota after acupuncture treatment and examined the existing problems and development prospects of acupuncture, microbiome, and poststroke depression, in order to provide new ideas for future acupuncture research.

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Lactobacillus pentosus LPQ1 attenuates depressive-like behavior in BALB/C mice induced by chronic unpredictable mild stress (CUMS)

Zeng,

Wei,

Zhang

et al. 2024

Food Bioscience

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Akkermansia muciniphila ameliorates depressive disorders in a murine alcohol-LPS (mALPS) model

Abstract: Depression is the most common mental disorder in the world. Recently, increasing studies have reported alcohol-related depression. However, there is no simple, efficient, and time-saving alcohol-related depression animal model yet....

Cited by 17 publications

References 55 publications

Using Inflammatory Biological Age To Evaluate the Preventing Aging Effect of a Polyphenol-Probiotic-Enhanced Dietary Pattern in Adults Aged 50 Years and Older

Using Inflammatory Biological Age To Evaluate the Preventing Aging Effect of a Polyphenol-Probiotic-Enhanced Dietary Pattern in Adults Aged 50 Years and Older

Acupuncture treatment for post-stroke depression: Intestinal microbiota and its role

Lactobacillus pentosus LPQ1 attenuates depressive-like behavior in BALB/C mice induced by chronic unpredictable mild stress (CUMS)

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