Using Inflammatory Biological Age To Evaluate the Preventing Aging Effect of a Polyphenol-Probiotic-Enhanced Dietary Pattern in Adults Aged 50 Years and Older

Abstract

A high-compliance dietary intervention was conducted for 2 weeks in adults aged 50 years and older to investigate the preventing aging effects of a polyphenol-probiotic-enhanced diet (P-diet) by using inflammatory biological age (IBA). Following the P-diet, levels of interleukin-6 (IL-6), IL-10, and C-reactive protein were reduced. These effects were accompanied by a significant increase in the richness of Lactobacillus and Bifidobacterium and decrease in CAG_56, as well as an increase in butyrate and acetate and decrease in lysine, uracil, and valine. We optimized a model by a back propagation artificial neural network to evaluate the degree of aging, with an R 2 of 0.68. After the P-diet intervention, IBA was younger than chronological age and the inflammatory aging potential (Δage) was observably reduced by 90.12%, with change in Δage having a direct negative association with Akkermansia. Overall, P-diet may alleviate chronic low-grade inflammation and thus prevent the procession of inflammatory aging.

Antiaging Effects of Human Fecal Transplants with Different Combinations of Bifidobacterium bifidum LTBB21J1 and Lactobacillus casei LTL1361 in d-Galactose-Induced Mice

“…33 The elevated levels of lysine and valine have been negatively associated with Bifidobacterium and correlate with the development of intestinal inflammation. 34 Chronic intake of high levels of BCAAs can lead to obesity and a shortened lifespan in mice. 35 Herein, levels of isoleucine, leucine, and valine in fecal metabolites were found to be significantly reduced after intervention with the centenariansourced probiotics, suggesting that the effects of these interventions on the amino acid metabolic profiles of the aged model may be intrinsically related to the enhancement of body health.…”

“…A low branched-chain amino acid (BCAA; leucine, isoleucine, and valine) diet can improve metabolic health and prolong lifespan in aging mice . The elevated levels of lysine and valine have been negatively associated with Bifidobacterium and correlate with the development of intestinal inflammation . Chronic intake of high levels of BCAAs can lead to obesity and a shortened lifespan in mice .…”

Bioinformatics Analysis and Experimental Verification of Exercise for Aging Mice in Different Brain Regions Based on Transcriptome Sequencing

“…As the principal immune cells within the brain, microglia modulate both the structural and functional aspects of synaptic plasticity [45], neurogenesis [46], protein aggregation [47], and other molecular mechanisms in conjunction with aging and NDD hallmarks to accelerate the disease process. A healthy diet could alleviate chronic inflammation and thus prevent the procession of inflammatory aging [48]. Physical exercise is also shown to be beneficial for primate and rodent health by mitigating age-induced inflammation and cognitive decline.…”