Adansonia digitata L. leaf extract attenuates lead-induced cortical histoarchitectural changes and oxidative stress in the prefrontal cortex of adult male Wistar rats

Abstract

ObjectivesAdansonia digitata L. is popularly known for the management of various neurological diseases in ethno-medicine. Studies have shown that lead toxicity is a possible risk factor for early onset of neurodegenerative disease. Hence, this study was designed to evaluate the effect of A. digitata aqueous leaf extract (ADALE) against lead-induced oxidative stress and histo-architectural changes in the prefrontal cortex of adult Wistar rats.MethodsSaline (10 mL/kg), ADALE (500 and 1000 mg/kg) and EDTA (55 mg/kg) were pretreated orally 30 min prior to lead acetate (LA) (120 mg/kg) administration to male Wistar rats (n=7) for 21 days. Thereafter, standard biochemical (superoxide dismutate, catalase, glutathionxe and malondialdehyde), histological (H&E) and histochemical assessment (crystyl fast violet stain for nissil substance) were carried out in the prefrontal cortex.ResultsADALE significantly (p<0.05) reversed LA-induced oxidative stress, as evidenced by increased catalase, superoxide dismutase and oxidized glutathione levels, and decreased malondialdehyde concentration in the prefrontal cortex. Also, the increase chromatolysis and neuronal pyknosis of the pyramidal neurons of the prefrontal cortex were significantly attenuated by ADALE.ConclusionsThe result of this study showed that A. digitata aqueous leaf extract attenuated lead acetate-induced cortical neurodegeneration via inhibition of oxidative stress.

Antioxidative properties of Ocimum gratissimum alters Lead acetate induced oxidative damage in lymphoid tissues and hematological parameters of adult Wistar rats

“…Globally, the antioxidative properties of various plants have been applied in the management of diseases especially in developing countries where they have been documented in traditional medicine [ 13 , [16] , [17] , [18] , [19] , [20] , 21 ]. About 80 % of individuals from developing countries are using traditional medicines to meet up their primary health care needs [ 21 ].…”

Datura metel stramonium exacerbates behavioral deficits, medial prefrontal cortex, and hippocampal neurotoxicity in mice via redox imbalance

“…The first line of the enzymatic antioxidant defence system includes SOD, CAT and GPx [ 38 ]. Antioxidant enzymes metabolise ROS generated from lipid peroxidation into less toxic molecules; for example, SOD which is essential for converting superoxide radicals to hydrogen peroxide (H2O2), halts oxidative stress by interacting with other neuroprotective antioxidants [ 39 – 42 ]. In this study, we assayed the levels of SOD, CAT, GPx and GSH following oral administration of DM for 28 days.…”

A Case for the Neuroprotective Potential of African Phytochemicals in the Management of Alzheimer’s Disease

“…There have been many preclinical experiments showing the neuroprotective potentials of African plants [217][218][219][220][221][222][223][224][225][226], but there have been no clinical trials for the agents. Therefore, future studies of these medicinal agents may present contrasting results in biological systems in the form of low catalytic activity in the CNS compared to preclinical and in vitro studies.…”