<i>ACE</i>and<i>ACTN3</i>Genes and Muscle Phenotypes in Nonagenarians

Bustamante-Ara, Natalia; Santiago, Catalina; Verde, Zoraida; Yvert, Thomas; Gómez‐Gallego, Félix; Rodríguez-Romo, Gabriel; González-Gil, P.; Ruiz, Jonatan R.; Lucía, Alejandro

doi:10.1055/s-0030-1247529

Cited by 39 publications

(41 citation statements)

References 21 publications

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“…With regard to this, in our study, we found no significant association between the ACTN3 R allele + ACE I allele combination (data not shown). As for non-athletic populations, our findings concur with recent data on elderly people showing no association (individually or combined) between power muscle phenotypes and ACE I/D + ACTN3 R577X genotype combinations (Bustamante-Ara et al 2010).…”

Section: Discussionsupporting

confidence: 91%

Does the ACE I/D polymorphism, alone or in combination with the ACTN3 R577X polymorphism, influence muscle power phenotypes in young, non-athletic adults?

et al. 2010

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We investigated the association of the angiotensin converting enzyme gene (ACE) insertion/deletion (I/D) polymorphism, alone or in combination with the a-actinin-3 gene (ACTN3) R577X polymorphism, with jumping (vertical squat and counter-movement jump tests) and sprint ability (30 m dash) in non-athletic, healthy young adults [N -281 (214 male), mean (SD) age 21 (2) years]. We did not observe any effect of the ACE I/D polymorphism on study phenotypes. We repeated the analyses separately in men and women and the results did not materially change. Likewise, the mean estimates of the study phenotypes were similar in subjects with the genotype combinations ACE II + ID and ACTN3 XX or ACE DD and ACTN3 RR + RX. We found no association between the ACE DD and ACTN3 RR + RX genotype combination and performance (>90th of the sex-specific

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Section: Discussionsupporting

confidence: 91%

Does the ACE I/D polymorphism, alone or in combination with the ACTN3 R577X polymorphism, influence muscle power phenotypes in young, non-athletic adults?

et al. 2010

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“…Other studies, however, have failed to support such findings (Bustamante-Ara et al 2010;Rodriguez-Romo et al 2010). This is mainly because the effect of a single polymorphism on physical function is quite small and therefore difficult to identify (Williams and Folland 2008).…”

Section: Discussionmentioning

confidence: 98%

“…Genetic variation has been used to answer questions as to how adaptations in skeletal muscle and interactions occur. It provides new frameworks to improve physical performance in older people (Ahmetov and Rogozkin 2009;Bustamante-Ara et al 2010;McCauley et al 2010;) being clinically relevant to identifying training response association of different genotypes associated with decreases of strength and function with aging (Garatachea and Lucia 2011). Although previous association studies have suggested a relevant genetic contribution to individual variability in muscle-related phenotypes, published data on specific gene variants are controversial (Bouchard and Rankinen 2001;Garatachea and Lucia 2011).…”

Section: Introductionmentioning

confidence: 99%

“…The influence of genetic factors on muscle phenotypes is controversial (Garatachea and Lucia 2011;Puthucheary et al 2011b) mainly because this is unlikely to be reducible to a few single genetic variants (Bustamante-Ara et al 2010). However, the proportion of each gene variant in explaining the variance of a complex trait such as this is totally unknown.…”

Section: Introductionmentioning

confidence: 99%

“…However, the proportion of each gene variant in explaining the variance of a complex trait such as this is totally unknown. Concerning ACE I/D and ACTN3 R/X polymorphisms, some studies have examined their influence in conjunction (Bustamante-Ara et al 2010; but the role of significant cumulative genotype-training effect remains to be elucidated.…”

Section: Introductionmentioning

confidence: 99%

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ACE I/D and ACTN3 R/X polymorphisms as potential factors in modulating exercise-related phenotypes in older women in response to a muscle power training stimuli

Pereira

Costa

Izquierdo

et al. 2012

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Genetic variation of the human ACE I/D and ACTN3 R577X polymorphisms subsequent to 12 weeks of high-speed power training on maximal strength (1RM) of the arm and leg muscles, muscle power performance (counter-movement jump), and functional capacity (sit-to-stand test) was examined in older Caucasian women [n0139; mean age 65.5 (8.2) years; 67.0 (10.0) kg and 1.57 (0.06) m]. Chelex 100 was used for DNA extraction, and genotype was determined by PCR-RFLP methods. Muscular strength, power, and functional testing were conducted at baseline (T1) and after 12 weeks (T2) of high-speed power training. At baseline, the ACE I/D and ACTN3 R/X polymorphisms were not associated with muscle function or muscularity phenotypes in older Caucasian women. After the 12-week high-speed training program, subjects significantly increased their muscular and functional capacity performance (p<0.05). For both polymorphisms, significant genotype-training interaction (p<0.05) was found in all muscular performance indices, except for 1RM leg extension in the ACE I/D (p00.187). Analyses of the combined effects between genotypes showed significant differences in all parameters (p<0.05) in response to high-speed power training between the power (ACTN3 RR+RX & ACE DD) versus "non-power" muscularity-oriented genotypes (ACTN3 XX & ACE II+ID)]. Our data suggest that the ACE and ACTN3 genotypes (single or combined) exert a significant influence in the muscle phenotypes of older Caucasian women in response to high-speed power training. Thus, the ACE I/D and ACTN3 R/X polymorphisms are likely factors in modulating exercise-related phenotypes in older women, particularly in response to a resistance training stimuli.

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Single and combined influence of ACE and ACTN3 genotypes on muscle phenotypes in octogenarians

et al. 2011

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We studied the single and combined influence of the ACE I/D and the ACTN3 R577X polymorphisms on muscle phenotypes (thigh muscles' cross-sectional area assessed with magnetic resonance imaging) and strength (maximal handgrip, 30-s chair stand test), functional ability during activities of daily living (Barthel index) and bone mineral density (proximal femur) in Caucasian (Spanish) community-dwelling old people [n = 81, 59 women; mean age 82.8 ± 4.8 years (range 71-93 years)]. We found no significantly differences in the aforementioned phenotypes across ACE and ACTN3 genotypes (all P > 0.05), except for handgrip in the ACE I/D recessive model (DD 19.5 ± 6.7 kg, ID 24.0 ± 9.1 kg, II 22.1 ± 7.9; P = 0.047), yet statistical significance disappeared after correction for multiple comparisons. Likewise, the analyses of the combined effects between genotypes did not yield any significant difference (all P > 0.05) between the two 'extreme' genotypes [theoretically 'power or muscularity oriented' [(ACTN3 RR + RX & ACE DD) versus 'non-power' (ACTN3 XX & ACE II + ID)]. The aforementioned analyses were adjusted by sex, age and physical activity levels as covariates. Logistic regression analysis revealed no significant association of single or combined effect of ACE and ACTN3 genotypes or genotype combination group (ACE + ACTN3) with sarcopenia (i.e. being in the lowest 25th sex-specific percentile for a combined score of the muscle and functional phenotypes we measured). Though ACE I/D and ACTN3 R577X polymorphisms are candidates to modulate exercise-related phenotypes in adults, our data suggest that they do not exert a major influence in the muscle phenotypes of old people. More studies with larger sample sizes are needed.

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ACEandACTN3Genes and Muscle Phenotypes in Nonagenarians

Cited by 39 publications

References 21 publications

Does the ACE I/D polymorphism, alone or in combination with the ACTN3 R577X polymorphism, influence muscle power phenotypes in young, non-athletic adults?

Does the ACE I/D polymorphism, alone or in combination with the ACTN3 R577X polymorphism, influence muscle power phenotypes in young, non-athletic adults?

ACE I/D and ACTN3 R/X polymorphisms as potential factors in modulating exercise-related phenotypes in older women in response to a muscle power training stimuli

Single and combined influence of ACE and ACTN3 genotypes on muscle phenotypes in octogenarians

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