Does the ACE I/D polymorphism, alone or in combination with the ACTN3 R577X polymorphism, influence muscle power phenotypes in young, non-athletic adults?

Rodríguez-Romo, Gabriel; Ruiz, Jonatan R.; Santiago, Catalina; Fiuza‐Luces, Carmen; González-Freire, Marta; Gómez‐Gallego, Félix; Morán, María; Lucía, Alejandro

doi:10.1007/s00421-010-1608-2

Cited by 31 publications

(23 citation statements)

References 38 publications

(44 reference statements)

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“…Other studies, however, have failed to support such findings (Bustamante-Ara et al 2010;Rodriguez-Romo et al 2010). This is mainly because the effect of a single polymorphism on physical function is quite small and therefore difficult to identify (Williams and Folland 2008).…”

Section: Discussionmentioning

confidence: 98%

ACE I/D and ACTN3 R/X polymorphisms as potential factors in modulating exercise-related phenotypes in older women in response to a muscle power training stimuli

Pereira

Costa

Izquierdo

et al. 2012

AGE

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Genetic variation of the human ACE I/D and ACTN3 R577X polymorphisms subsequent to 12 weeks of high-speed power training on maximal strength (1RM) of the arm and leg muscles, muscle power performance (counter-movement jump), and functional capacity (sit-to-stand test) was examined in older Caucasian women [n0139; mean age 65.5 (8.2) years; 67.0 (10.0) kg and 1.57 (0.06) m]. Chelex 100 was used for DNA extraction, and genotype was determined by PCR-RFLP methods. Muscular strength, power, and functional testing were conducted at baseline (T1) and after 12 weeks (T2) of high-speed power training. At baseline, the ACE I/D and ACTN3 R/X polymorphisms were not associated with muscle function or muscularity phenotypes in older Caucasian women. After the 12-week high-speed training program, subjects significantly increased their muscular and functional capacity performance (p<0.05). For both polymorphisms, significant genotype-training interaction (p<0.05) was found in all muscular performance indices, except for 1RM leg extension in the ACE I/D (p00.187). Analyses of the combined effects between genotypes showed significant differences in all parameters (p<0.05) in response to high-speed power training between the power (ACTN3 RR+RX & ACE DD) versus "non-power" muscularity-oriented genotypes (ACTN3 XX & ACE II+ID)]. Our data suggest that the ACE and ACTN3 genotypes (single or combined) exert a significant influence in the muscle phenotypes of older Caucasian women in response to high-speed power training. Thus, the ACE I/D and ACTN3 R/X polymorphisms are likely factors in modulating exercise-related phenotypes in older women, particularly in response to a resistance training stimuli.

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Section: Discussionmentioning

confidence: 98%

ACE I/D and ACTN3 R/X polymorphisms as potential factors in modulating exercise-related phenotypes in older women in response to a muscle power training stimuli

Pereira

Costa

Izquierdo

et al. 2012

AGE

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“…and colleagues published in this issue (Rodríguez-Romo et al 2010). The results of this latter study show that neither of single polymorphisms in two candidates of muscle phenotypic control, angiotensin converting enzyme (ACE) and a-actinin-3 (ACTN3), is associated with explosive muscle performance in young healthy adults.…”

mentioning

confidence: 95%

Linking genes with exercise: where is the cut-off?

2010

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“…Os primersutilizados foram F-5'-CTGGAGACCACTCCCATCCTTTCT-3' e R-5'-GATGTGGCCATCACATTCGTCAGAT-3'. Os fragmentos sem inserção (alelo D) e com inserção (alelo I 35,10,36 .…”

Section: Genotipagemunclassified

Efeito de polimorfismos genéticos da ECA e da ACTN3 na capacidade e na incidência de quedas em idosas

Frattini¹,

Ferrari²,

Chiaratto³

et al. 2016

J Physical Edu

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RESUMOO objetivo deste estudo foi analisar a associação dos polimorfismos genéticos I/D da enzima conversora de angiotensina (ECA) e R/X da proteína alfa-actinina 3 (ACTN3) com capacidade funcional e prevalência de quedas em mulheres no final da idade adulta e início da terceira idade. Foram genotipadas 60 mulheres e com base nestas características genéticas foram divididas em grupos e submetidas a medidas de estatura, massa corporal, testes de força de preensão manual, sentar e levantar, coordenação, alcance funcional e alcance lateral, além de responderem a um questionário sobre o nível de atividade física. Os resultados mostraram que não houve diferença estatística entre os genótipos da ECA e da ACTN3 em nenhuma variável. Porém, em relação aos polimorfismos da ACTN3, a prevalência de quedas no grupo XX foi em termos descritivos consideravelmente maior do que a do grupo RR/RX (42% versus 21% em um ano). Palavras-chave: Idosos. Equilíbrio. Exercício físico. ABSTRACTThe objective of this study was to analyze the association of angiotensin-converting enzyme (ACE) I/D and alpha-actinin 3 (ACTN3) R/X genetics polymorphisms with functional capacity and fall prevalence in women in late adulthood and early old age. Sixty women were genotyped and based on these genetic characteristics they were separated in groups and submitted to measurements of height, body mass, handgrip test, chair stand test, coordination test, functional reach test and lateral reach test, besides answering a questionnaire about the level of physical activity. Results showed no statistical difference between ACE and ACTN3 genotypes in all variables. However, regarding ACTN3 polymorphisms, fall prevalence in group XX was bigger than in the RR/RX group (42% versus 21% in a year) using descriptive statistics. Keywords: Elderly people. Balance. Physical exercise. IntroduçãoNos últimos anos estudos que abordam o processo de envelhecimento têm recebido destaque especialmente devido ao crescimento da expectativa de vida da população mundial em ritmo acelerado 1 e à constante preocupação em proporcionar um envelhecimento saudável 2 . Sabe-se que velhice não é sinônimo de doença, porém ela está associada a riscos potenciais para a instalação de incapacidades e da dependência física e cognitiva 2 . Por volta de 60 anos começa a ficar aparente a perda de força muscular relacionada inclusive à atrofia seletiva das fibras musculares do tipo II, trazendo sérias limitações para o cotidiano dos idosos 3-4 .De acordo com Nóbrega et al. 4 , a diminuição da massa óssea, as mudanças na cartilagem articular e em parâmetros biomecânicos também prejudicam a função locomotora e a flexibilidade, dificultando o deslocamento e aumentando o risco de lesões. E todos estes declínios funcionais característicos do envelhecimento contribuem para a maior incidência de

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Does the ACE I/D polymorphism, alone or in combination with the ACTN3 R577X polymorphism, influence muscle power phenotypes in young, non-athletic adults?

Cited by 31 publications

References 38 publications

ACE I/D and ACTN3 R/X polymorphisms as potential factors in modulating exercise-related phenotypes in older women in response to a muscle power training stimuli

ACE I/D and ACTN3 R/X polymorphisms as potential factors in modulating exercise-related phenotypes in older women in response to a muscle power training stimuli

Linking genes with exercise: where is the cut-off?

Efeito de polimorfismos genéticos da ECA e da ACTN3 na capacidade e na incidência de quedas em idosas

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